Sulfatides ameliorate experimental autoimmune neuritis by suppressing Th1/Th17 cells.
J Neuroimmunol. 2018 Nov 14;326:55-61
Authors: Wang SX, Yang CL, Zhang M, Zhang P, Liu RT, Zhang N, Yang B, Li XL, Dou YC, Duan RS
Abstract
Sulfatides have immunomodulatory functions, and play protective roles in multiple autoimmune diseases. In the present study, we showed that sulfatides ameliorated experimental autoimmune neuritis in Lewis rats induced with bovine peripheral myelin, which was associated with decreased proportions of Th1 and Th17 cells. Furthermore, compared control group, cells from sulfatide-treated rats exhibited lower potential in proliferation and IL-17 secretion in the presence of BPM or ConA in vitro. Moreover, sulfatides also reduced the proportions of NK and NKT cells. In summary, our study indicated that sulfatides might become a new therapeutic agent in Guillain-Barré syndrome in the future.
PMID: 30481614 [PubMed - as supplied by publisher]
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