High C‐reactive protein to lymphocyte ratio predicts mortality outcomes of patients with severe fever suffering from thrombocytopenia syndrome: a multi‐centre study in China.

alexandrossfakianakis shared this article with you from Inoreader High C‐reactive protein to lymphocyte ratio predicts mortality outcomes of patients with severe fever suffering from thrombocytopenia syndrome: a multi‐centre study in China. via Journal of Medical Virology Abstracts Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease caused by the SFTS virus (SFTSV). This study aimed to evaluate the predictive power of C-reactive protein to lymphocyte ratio (CLR) and establish an early-warning model for SFTS mortality. We retrospectively analysed hospitalised SFTS patients in six clinical centres from May 2011 to May 2022. The efficacy of CLR prediction was evaluated by the receiver operating characteristic (ROC) analysis. A nomogram was established and validated. 882 SFTS patients (median age 64 years, 48.5% male) were enrolled in this study, with a mortality rate of 17.8%. The area under the ROC curve (AUC) of CLR was 0.878 (95% CI: 0.850-0.903, P<0.001), which demonstrates high predictive strength. The least absolute shrinkage and selection operator (LASSO) regression selected seven potential predictors. Multivariate logistic regression analysis determined three independent risk factors, including CLR, to construc t the nomogram. The performance of the nomogram displayed excellent discrimination and calibration, with significant net benefits in clinical uses. CLR is a brand-new predictor for SFTS mortality. The nomogram based on CLR can serve as a convenient tool for physicians to identify critical SFTS cases in clinical practice. This article is protected by copyright. All rights reserved. View on Web

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