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Sunday, November 6, 2022

Relationship between carotid intima‐media thickness and periodontal disease in a Japanese urban population with and without hypertension: the Suita Study

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Aim

To investigate the association between periodontal disease and atherosclerosis and examine whether the association is modified by hypertension status.

Materials and Methods

In this cross-sectional study, 1,472 Japanese individuals aged 50-79 years who underwent a medical check-up, dental examination, and carotid ultrasonography were studied. Carotid atherosclerosis was expressed as the maximum and mean carotid intima-media thickness (max-IMT, mean-IMT) and the presence of stenosis (>75%). Periodontal status was examined by the Community Periodontal Index (CPI, codes 0-4). The participants were divided into 3 groups according to periodontal status (CPI0-2, CPI3, CPI4).

Results

A positive correlation was found between mean-IMT and periodontal disease after adjustment for cardiovascular risk factors in the entire cohort (mean-IMT in hypertensives: CPI0-2: 0.848 mm, CPI3: 0.857 mm, CPI4: 0.877 mm; normotensives: 0.782, 0.802, 0.826). In the entire cohort, the multivariable-adjusted odds ratio of stenosis based on mean-IMT significantly increased according to periodontal status in normotensives (odds ratio; CPI0-2: 1, CPI3: 1.39, CPI4: 2.53; P for trend=0.004), but only marginally significantly increased in hypertensives (1, 1.15, 1.55; P for trend=0.063). No significant relationships were observed for max-IMT in all analyses.

Conclusion

We observed an association between periodontal disease and atherosclerosis in normotensive and hypertensive participants.

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