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Αλέξανδρος Γ. Σφακιανάκης

Tuesday, August 23, 2022

Immune‐modified Glasgow prognostic score: A new prognostic marker for head and neck cancer

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Background

The modified Glasgow prognostic score (mGPS) includes C-reactive protein and serum albumin levels and is a useful prognostic tool for malignant tumors. The immune system affects cancer progression and recurrence and treatment response. We hypothesized that increasing the lymphocyte count improves mGPS, and we created a new prognostic marker termed immune-mGPS (imGPS).

Methods

This study included 461 patients with head and neck squamous cell carcinoma (HNSCC). The imGPS was calculated as the conventional mGPS with one additional point for a low lymphocyte count (<1250/μL).

Results

Addition of the lymphocyte count to mGPS significantly increased the area under the time-dependent receiver operating characteristic curve for overall and progression-free survivals. The added predictive abilities of this tool were supported by improvement in both net reclassification and integrated discrimination.

Conclusion

imGPS is a more accurate predictor of clinical outcome in patients with HNSCC than mGPS.

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