Imatinib-induced retroperitoneal fibrosis in a child with chronic myeloid leukemia: a case report

xlomafota13 shared this article with you from Inoreader Imatinib-induced retroperitoneal fibrosis in a child with chronic myeloid leukemia: a case report Via American Journal of Blood Research Am J Blood Res. 2021 Dec 15;11(6):600-604. eCollection 2021. ABSTRACT A 12 year old boy with chronic myeloid leukemia (CML) presenting with bilateral pitting pedal edema and abdominal distension after about 41 months of imatinib therapy and was diagnosed to have retroperitoneal fibrosis (RPF) based on imaging and biopsy findings. He was found to have bilateral hydroureteronephrosis needing double-J stenting to the more severely affected right ureter. Imatinib was briefly interrupted and restarted later due to rising transcript levels and unavailability of other alternatives at that time which was later substituted by dasatinib once generic versions became available. Child remains asymptomatic after 18 months of DJ stenting. RPF is a rare complication of imatinib this being the second case reported in the literature. PMID:35103114 | PMC:PMC8784644 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.