The role of TNFTNFα/p53 pathway in endometrial cancer mouse model administered with apple seed extract

xlomafota13 shared this article with you from Inoreader The role of TNFTNFα/p53 pathway in endometrial cancer mouse model administered with apple seed extract Via Cellular and Molecular Biology Histol Histopathol. 2021 Nov 5:18393. doi: 10.14670/HH-18-393. Online ahead of print. ABSTRACT Recent studies regarding the ability to relieve and reconstitute the endometrium in the treatment of endometrial cancer are limited. In this study, to analyze endometrial cancer, early endometrial cancer was induced by injecting a colon cancer cell line into the lower abdominal cavity of mice. Subsequently, the apple seed extract was administered orally to determine if the extract could affect the endometrial cancer. Administration of apple seed extract to the endometrial cancer model confirmed that the apoptosis suppressing mechanism was downregulated concurrently with the reduced expression of NF-κB. In contrast, the TNFα/p53 pathway upregulated the apoptosis. A number of clinical inferences could be derived from the results of this study; moreover, the administration of apple seed extract in a cancer metastasis model has not been reporte d in earlier toxicity induction studies. The results of this study indicated that the apple seed extract partially enhances apoptosis and the immune function related factors in endometrial cells. By improving tissue remodeling, the extract may help to restore the endometrium. PMID:34738229 | DOI:10.14670/HH-18-393 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.