The role of alternative splicing in human cancer progression

xlomafota13 shared this article with you from Inoreader The role of alternative splicing in human cancer progression Via American Journal of Cancer Research Am J Cancer Res. 2021 Oct 15;11(10):4642-4667. eCollection 2021. ABSTRACT In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the translation of a limited number of coding genes into a large number of proteins with different functions. Although, alternative splicing is common in normal cells, it also plays an important role in cancer development. Alteration in splicing mechanisms and even the participation of non-coding RNAs may cause changes in the splicing patterns of cancer-related genes. This article reviews the latest research on alternative splicing in cancer, with a view to presenting new strategies and guiding future studies related to pathological mechanisms associated with cancer. PMID:34765285 | PMC:PMC8569372 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.