The emerging landscape of long non-coding RNAs in hepatocellular carcinoma

xlomafota13 shared this article with you from Inoreader The emerging landscape of long non-coding RNAs in hepatocellular carcinoma Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Sep 15;14(9):920-937. eCollection 2021. ABSTRACT Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers. HCC shows high prevalence and lethality caused by a variety of etiologic factors. However, the underlying mechanisms and the diagnostic markers identifying patients at risk in advance has not been entirely elucidated. Long non-coding RNAs (lncRNAs) are a subgroup of non-coding RNAs greater than 200 nucleotides in length with no protein-coding capability. With the progress in sequencing technologies and bioinformatic tools, the landscape of lncRNAs is being revealed. Numerous discoveries point out that lncRNAs participate in HCC carcinogenesis and metastasis through altering cell proliferation and invasion ability, apoptosis, and chemo- or radio-sensitivity. Moreover, lncRNA is easy to detect compared to the traditional diagnostic methods. This review summarizes the mechanisms of m ajor lncRNAs in HCC discovered in recent years and lncRNAs as early diagnostic markers for HCC. PMID:34646411 | PMC:PMC8493264 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.