Multiple skull base defects: features of pathogenesis, diagnosis and treatment

xlomafota13 shared this article with you from Inoreader Multiple skull base defects: features of pathogenesis, diagnosis and treatment Via leak of cerebrospinal fluid Zh Vopr Neirokhir Im N N Burdenko. 2021;85(4):58-63. doi: 10.17116/neiro20218504158. ABSTRACT OBJECTIVE: To determine the risk factors of multiple skull base defects, as well as features of diagnosis and treatment of this pathology. MATERIAL AND METHODS: A retrospective analysis included 39 patients who underwent surgery for nasal CSF leakage at the Burdenko Neurosurgical Center in 2000-2019. The study recruited patients with multiple simultant skull base defects. RESULTS: Traumatic defects were observed in 23 (59%) patients, spontaneous defects - in 16 (41%) cases. All patients underwent endoscopic endonasal closure of skull base defects with autografts. CONCLUSION: Multiple defects are more common in severe traumatic brain injury. The main risk factors of multiple spontaneous defects are female sex and overweight. Adequate diagnosis implies high-resolution CT (slice width 0.5-1 mm), as well as intraoperative control of all suspicious and «weak» areas. Endoscopic endonasal technique is effective and safe for multiple skull base defects (efficiency 97%). PMID:34463451 | DOI:10.17116/neiro20218504158 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.