SERPINB11 Expression Is Associated With Prognosis of High-grade Serous and Clear Cell Carcinoma of the Ovary

xlomafota13 shared this article with you from Inoreader <em>SERPINB11</em> Expression Is Associated With Prognosis of High-grade Serous and Clear Cell Carcinoma of the Ovary Via In vivo (Athens, Greece) In Vivo. 2021 Sep-Oct;35(5):2647-2653. doi: 10.21873/invivo.12547. ABSTRACT BACKGROUND/AIM: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). MATERIALS AND METHODS: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. RESULTS: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of C CC was found. CONCLUSION: SERPINB11 expression maybe a prognostic biomarker for HGSC. PMID:34410952 | DOI:10.21873/invivo.12547 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.