Effect of erythropoietin on angiogenic potential of dental pulp cells

xlomafota13 shared this article with you from Inoreader Effect of erythropoietin on angiogenic potential of dental pulp cells Via Experimental and therapeutic medicine Exp Ther Med. 2021 Oct;22(4):1079. doi: 10.3892/etm.2021.10513. Epub 2021 Jul 28. ABSTRACT Erythropoietin (EPO) is a 34-kDa glycoprotein that possesses the potential for angiogenesis, as well as anti-inflammatory and anti-apoptotic properties. The present study aimed to examine the effect of EPO on the angiogenesis of dental pulp cells (DPCs) and to explore the underlying mechanisms of these effects. It was demonstrated that EPO not only promoted DPCs proliferation but also induced angiogenesis of DPCs in a paracrine fashion. EPO enhanced the angiogenic capacity by stimulating DPCs to secrete a series of angiogenic cytokines. ELISA confirmed that high concentrations of EPO increased the production of MMP-3 and angiopoietin-1 but decreased the secretion of IL-6. Furthermore, EPO activated the ERK1/2 and p38 signaling pathways in DPCs, while inhibition of these pathways diminished the angiogenesis capacity of DPCs. The present study sugg ested that EPO may have an important role in the repair and regeneration of dental pulp. PMID:34447472 | PMC:PMC8355638 | DOI:10.3892/etm.2021.10513 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.