MicroRNA-296-5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer

xlomafota13 shared this article with you from Inoreader MicroRNA-296-5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer Via Experimental and therapeutic medicine Exp Ther Med. 2021 Aug;22(2):793. doi: 10.3892/etm.2021.10225. Epub 2021 May 24. ABSTRACT An increasing body of evidence indicates the involvement of microRNAs (miRNAs/miRs) in the initiation and progression of colorectal cancer (CRC). miR-296-5p was recently identified as a tumor suppressor in a variety of human cancer types; however, its function in CRC remains largely unknown. The present study demonstrated that the expression of miR-296-5p was significantly downregulated in CRC tissues and cell lines. The overexpression of miR-296-5p markedly inhibited proliferation, and induced cell cycle arrest and apoptosis in CRC cells. Bioinformatics analysis suggested that high mobility group AT-hook 1 (HMGA1) may be a target of miR-296-5p in CRC cells. Further experiments showed that miR-296-5p bound the 3'-untranslated region of HMGA1 and decreased its expression in CRC cells. HMGA1 was overexpressed in CRC tissues and was inversely correla ted with the expression of miR-296-5p. The restoration of HMGA1 significantly reversed the inhibitory effect of miR-296-5p on the proliferation of CRC cells. Overall, the findings of the present study indicate that miR-296-5p suppressed the progression of CRC, at least partially via targeting HMGA1. Thus, miR-296-5p is a potential target for novel therapies in CRC. PMID:34093749 | PMC:PMC8170657 | DOI:10.3892/etm.2021.10225 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.