Tumor-treating fields (TTFields)-based cocktail therapy: a novel blueprint for glioblastoma treatment

xlomafota13 shared this article with you from Inoreader Tumor-treating fields (TTFields)-based cocktail therapy: a novel blueprint for glioblastoma treatment Via American Journal of Cancer Research Am J Cancer Res. 2021 Apr 15;11(4):1069-1086. eCollection 2021. ABSTRACT Glioblastoma is one of the most common malignant tumors in the central nervous system. Due to the high plasticity, heterogeneity and complexity of the tumor microenvironment, these tumors are resistant to almost all therapeutic strategies when they reach an advanced stage. Along with being a unique and effective way to kill cancer cells, tumor-treating fields (TTFields) has emerged as a breakthrough among glioblastoma therapies since the advent of temozolomide (TMZ), and the combination of these treatments has gradually been promoted and applied in the clinic. The combination of TTFields with other therapies is particularly suitable for this type of "cold" tumors and has attracted a large amount of attention from clinicians and researchers in the era of cancer cocktail therapy. Here, we introduced the current treatment regimen for glioblastoma, highlighting the un ique advantages of TTFields in the treatment of glioblastoma. Then, we summarized current glioblastoma clinical trials that combine TTFields and other therapies. In addition, the main and potential mechanisms of TTFields were introduced to further understand the rationale for each combination therapy. Finally, we focused on the most advanced technologies applied in glioblastoma research and treatment and the prospect of their combination with TTFields. This review provides a unique overview of glioblastoma treatment. PMID:33948346 | PMC:PMC8085847 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.