An overview of genetic predisposition to familial hematological malignancies

xlomafota13 shared this article with you from Inoreader An overview of genetic predisposition to familial hematological malignancies Via Association française pour l'étude du cancer Bull Cancer. 2021 May 26:S0007-4551(21)00178-8. doi: 10.1016/j.bulcan.2021.03.013. Online ahead of print. ABSTRACT Genetic predisposition has been always noted in the context of familial hematological malignancies. Epidemiological studies have provided evidence consisting of an increased risk to develop blood cancer in relatives diagnosed with the same pathology and characterized by early age at diagnosis and higher severity compared to sporadic forms. With the emergence of new genomic testing approaches, the prevalence of familial aggregations of hematological malignancies seems to be under estimated. The heterogeneity of clinical features explains the wide number of genes' mutations reported to date and the variable penetrance of variants. Nevertheless, the genetic basis of familial hematological malignancies is still not well understood. Identifying the genetic background in familial aggregations provides a valuable tool for prognos tic evaluation, personalized treatment and better genetic counseling in high-risk families. Herein, we provide an overview of genes reported in the last few years in association to hematological malignancies including familial form of Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, acute Myeloid Leukemia and acute Lymphoblastic Leukemia. PMID:34052033 | DOI:10.1016/j.bulcan.2021.03.013 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.