Long non-coding RNA SUMO1P3 promotes tumour progression by regulating cell proliferation and invasion in glioma

xlomafota13 shared this article with you from Inoreader Long non-coding RNA SUMO1P3 promotes tumour progression by regulating cell proliferation and invasion in glioma Via Experimental and therapeutic medicine Exp Ther Med. 2021 May;21(5):491. doi: 10.3892/etm.2021.9922. Epub 2021 Mar 16. ABSTRACT Gliomas account for 50% of primary brain tumours in the central nervous system. Small ubiquitin-like modifier 1 pseudogene 3 (SUMO1P3), a newly identified long non-coding RNA (lncRNA), serves an oncogenic role in various types of cancer. The aim of the present study was to investigate the effect of SUMO1P3 on glioma progression. The results demonstrated that SUMO1P3 expression was upregulated in glioma tissues and cell lines. Furthermore, SUMO1P3 was associated with a poor overall survival of patients with glioma. The results of the in vitro cell proliferation and flow cytometry assays demonstrated that SUMO1P3-knockdown suppressed cell proliferation and cell cycle. The results of the wound healing and Transwell assays demonstrated that SUMO1P3-knockdown significantly repressed cell migration and invasion. In addition, SUMO1P3 promoted gliom a by regulating the expression levels of β-catenin, cyclin-D1, N-cadherin and E-cadherin. Overall, the results of the present study suggested that SUMO1P3 may act as an oncogene by regulating cell proliferation, cell cycle, cell migration and invasion in glioma, and may represent a novel diagnostic biomarker and therapeutic target for glioma. PMID:33791000 | PMC:PMC8005699 | DOI:10.3892/etm.2021.9922 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.