Actin-binding protein anillin promotes the progression of hepatocellular carcinoma in vitro and in mice

xlomafota13 shared this article with you from Inoreader Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Via Experimental and therapeutic medicine Exp Ther Med. 2021 May;21(5):454. doi: 10.3892/etm.2021.9885. Epub 2021 Mar 1. ABSTRACT Hepatocellular carcinoma (HCC) is a common type of tumor with high mortality worldwide. Investigations associated with the molecular etiology of HCC and screening novel therapeutic targets are still urgently in need. Anillin (ANLN), as a type of evolutionarily conserved actin-binding protein, is involved in multiple cellular processes. ANLN widely affected the progression and metastasis of several types of cancer, and its overexpression was frequently demonstrated in previous studies. The present study demonstrated high expression of ANLN in human HCC tissues, which was also associated the prognosis of patients with HCC. The associations between ANLN expression and the clinicopathological features were determined, including the number of tumor nodes (P=0.011) and tumor size (P=0.003) of patients with HCC. It was found that ANLN promoted cell prolife ration, invasion and migration of HCC cells in vitro, and affected tumor growth in vivo. Therefore, ANLN is suggested as a promising therapeutic target for the treatment of HCC. PMID:33747188 | PMC:PMC7967816 | DOI:10.3892/etm.2021.9885 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.