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Αλέξανδρος Γ. Σφακιανάκης

Sunday, February 14, 2021

Presence and duration of feeding tube in a 5‐year cohort of patients with head and neck cancer treated with curative intensity‐modulated radiation therapy

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Abstract

Background

Our study assessed post‐radiation therapy (RT) G‐tube presence, duration, and clinical predictors in patients with head and neck cancer (HNC).

Methods

We identified those 1–5‐years post‐RT with stage III/IV nasopharyngeal, oropharyngeal, hypopharyngeal, laryngeal, or unknown primaries. Logistic regression identified predictors of post‐RT G‐tube presence, Kaplan–Meier analysis estimated G‐tube days, and log‐rank test compared by tumor site.

Results

The 977 patients had mean age 60.6 ± 11.6 years, 804 (82.3%) male, 764 (78.2%) stage IV, and 618 (63.3%) oropharyngeal primaries. All patients received intensity‐modulated RT (IMRT), 571 (58.4%) received chemotherapy, and 698 (71.4%) prophylactic G‐tube. G‐tube prevalence 1‐ and 5‐years post‐IMRT was 7.1% and 4.8%, respectively. Median post‐IMRT G‐tube days were overall 63 (95%CI: 56–70), nasopharynx 119 (95%CI: 109–131), oropharynx 57 (95%CI: 51–68), hypopharynx 126 (95%CI: 77–256), larynx 53 (95%CI: 21–63), unknown 30 (95%CI: 17–55), of which hypopharynx was highest p < 0.001.

Conclusions

At an institution offering prophylactic G‐tube for patients with advanced HNC, no differences were found in yearly G‐tube use 1–5 years post‐IMRT. Across all patients, median post‐IMRT days with G‐tube was 63 day but those with hypopharyngeal tumors registered the most days.

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