A Magnetically Guided Self‐Rolled Microrobot for Targeted Drug Delivery, Real‐Time X‐Ray Imaging, and Microrobot Retrieval

xloma.fota13 shared this article with you from Inoreader A Magnetically Guided Self‐Rolled Microrobot for Targeted Drug Delivery, Real‐Time X‐Ray Imaging, and Microrobot Retrieval Via Advanced Healthcare Materials A magnetically guided self‐rolled microrobot is developed for targeted drug delivery. The self‐rolled microrobot is capable of loading anticancer drug and X‐ray contrast agent using its structural property. The microrobot can perform precise targeting through autonomous driving under X‐ray imaging and rapidly release drugs through near‐infrared stimulus. After drug delivery, the microrobot can be safely recovered using magnetic field generators. Abstract Targeted drug delivery using a microrobot is a promising technique capable of overcoming the limitations of conventional chemotherapy that relies on body circulation. However, most studies of microrobots used for drug delivery have only demonstrated simple mobility rather than precise targeting methods and prove the possibility of biodegradation of implanted microrobots after drug delivery. In this study, magnetically guided self‐rolled microrobot that enables autonomous navigation‐based targeted drug delivery, real‐time X‐ray imaging, and microrobot retrieval is proposed. The microrobot, composed of a self‐rolled body that is printed using focused light and a surface with magnetic nanoparticles attached, demonstrates the loading of doxorubicin and an X‐ray contrast agent for cancer therapy and X‐ray imaging. The microrobot is precisely mobilized to the lesion site through automated targeting using magnetic field control of an electromagnetic actuation system under r eal‐time X‐ray imaging. The photothermal effect using near‐infrared light reveals rapid drug release of the microrobot located at the lesion site. After drug delivery, the microrobot is recovered without potential toxicity by implantation or degradation using a magnetic‐field‐switchable coiled catheter. This microrobotic approach using automated control method of the therapeutic agents‐loaded microrobot has potential use in precise localized drug delivery systems. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.