Diffuse intrinsic pontine glioma

xlomafota.13 shared this article with you from Inoreader Diffuse intrinsic pontine glioma: current insights and future directions Via Latest Results for Chinese Neurosurgical Journal Abstract Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor and the leading cause of brain tumor–related death in children. As several clinical trials over the past few decades have led to no significant improvements in outcome, the current standard of care remains fractionated focal radiation. Due to the recent increase in stereotactic biopsies, tumor tissue availabilities have enabled our advancement of the genomic and molecular characterization of this lethal cancer. Several groups have identified key histone gene mutations, genetic drivers, and methylation changes in DIPG, providing us with new insights into DIPG tumorigenesis. Subsequently, there has been increased development of in vitro and in vivo models of DIPG which have the capacity to unveil novel therapies and strategies for drug delivery. This review outlines the clinical characteristics, genetic landscape, models, and current treatments and hopes to shed light on novel t herapeutic avenues and challenges that remain. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.