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Sunday, December 27, 2020

Comparison of Polycaprolactone and Calcium Hydroxylapatite Dermal Fillers in A Rat Model

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ABSTRACT

Background

Polycaprolactone and Calcium hydroxylapatite are semi‐permanent dermal fillers that are frequently preferred in the last decade.

Objective

This study aims to compare the effects of these two fillers in the rat skin.

Methods

30 female rats were divided into; control, polycaprolactone, and calcium hydroxylapatite group. Tissue samples taken at the 2nd and 4th month were stained with hematoxylin‐eosin, Masson trichrome, collagen type 1, and 3 immunohistochemical antibodies. Collagen density was quantitatively compared using the Image J computer program.

Results

At 2 and 4 month, the density of collagen increased in both filler groups compared to the control group. There was no significant difference between collagen density or type 1 and type 3 collagen H scores in the filler groups. The number of fibroblast nuclei was significantly higher in the PCL group at 4 month compared to the other two groups. Dermis thickness was found to be superior in both filler groups compared to the control group at the 4th month, there was no significant difference between the filler groups.

Conclusions

We compared the effect of CaHA and PCL filler on collagenization histologically and immunohistochemically. We found that PCL and CaHA fillers are effective in increasing dermal collagen density, type 1 and type 3 collagen amount, and preventing dermis atrophy and showed that they have no advantage over each other in this respect. We have shown that PCL filler provides more fibroblast increase compared to CaHA filler and the effect of stimulating fibroblast proliferation takes longer.

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