Epidemiological Research of Microtia Combined With Congenital Heart Disease

pa.ythelady61 shared this article with you from Inoreader Epidemiological Research of Microtia Combined With Congenital Heart Disease Via Journal of Craniofacial Surgery - Published Ahead-of-Print Summary: Congenital heart disease (CHD) is one of the most common combined malformations of microtia. There is currently no specific study that investigates the relationship between microtia and CHD. Methods: This study collected microtia inpatients admitted from May 1, 2015 to July 31, 2016. The diagnosis of CHD was based on patient's symptoms, past history, and echocardiography. Pearson χ2 test was used to analyze the correlation between CHD and microtia. Results: A total of 30 cases (3.35%) were documented with CHD, including atrial septal defect (12/40.00%), ventricular septal defect (7/23.30%), patent ductus arteriosus (2/6.70%), complex congenital heart disease (3/10.00%), combined CHD (2/6.70%) and other malformations (4/13.30%). Analysis showed no statistically significant relation between CHD and the side of affected ear or gender. Conclusions: The occurrence of CHD in microtia patients was higher than that in the general population. The relationship between them was explored mainly from the etiological perspective. Microtia and CHD were often combined in syndromes such as Goldenhar syndrome, 22q11 deletion syndrome, and CHARGE syndrome. Absence of genes or abnormal embryo development associated with these syndromes leads to the occurrence of both. Address correspondence and reprint requests to Qingguo Zhang, MD, Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 33 Ba-Da-Chu Road, Shi Jing Shan District, 100144 Beijing, China; E-mail: plasticsurgern163@163.com Received 23 January, 2019 Accepted 27 October, 2020 This study was supported by grants from the National Natural Science Foundation of China (81571924 to Q-GZ, 81701930 to B-QW, and 81671933 to J-TH). The authors report no conflicts of interest. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jcraniofacialsurgery.com). © 2020 by Mutaz B. Habal, MD. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.