MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles.

ola Kala shared this article with you from Inoreader MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles. Μέσω pubmed: small cell carcinoma... Related Articles MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles. Heliyon. 2020 Nov;6(11):e05436 Authors: Ghafouri-Fard S, Gholipour M, Taheri M, Shirvani Farsani Z Abstract Head and neck squamous cell carcinomas (HNSCCs) are human malignancies associated with both genetic and environmental factors. MicroRNAs (miRNAs) as a group of small non-coding RNAs have prominent roles in the development of this kind of cancer. Expressions of several miRNAs have been demonstrated to be increased in HNSCC samples vs. non-malignant tissues. In silico prediction tools and functional analyses have confirmed the function of some miRNAs in the modulation of cancer-associated targets, thus indicating these miRNAs as onco-miRs. Moreover, numerous miRNAs have been down-regulated in HNSCC samples. Their targets mostly enhance cell proliferation or inhibit apoptosis. miRNAs signature has practical implications in the diagnosis, staging, and management of HNSC. Most notably, numerous miRNAs have been shown to alter response of tumor cells to anti-cancer drugs such as cisplatin and doxorubicin. Circulating levels of these small transcripts have been suggested as promisin g biomarkers for diagnosis of HNSCC. In the present manuscript, we sum up the available literature regarding the miRNAs signature in HNSCC and their role as diagnostic/prognostic biomarkers. PMID: 33204886 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.