Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer

alkiviadis.1961 shared this article with you from Inoreader Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer Via Hindawi Publishing Corporation Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size () and American Joint Committee on Cancer (AJCC) stage (). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppr essor and a potential therapeutic target for colon cancer patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.