Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database

alkiviadis.1961 shared this article with you from Inoreader Hemangiopericytoma: Incidence, Treatment, and Prognosis Analysis Based on SEER Database Via Hindawi Publishing Corporation Background. Hemangiopericytomas are rare tumors derived from pericytes surrounding the blood vessels. The clinicopathological characteristics and prognosis of hemangiopericytoma patients remain mostly unknown. In this retrospective cohort study, we assessed the clinicopathological characteristics of hemangiopericytoma patients, as well as the clinical usefulness of different treatment modalities. Material and Methods. We collected the clinicopathological data (between 1975 and 2016) of hemangiopericytoma and hemangioendothelioma patients from the Surveillance, Epidemiology, and End Results (SEER) database. Incidence, treatment, and patient prognosis were assessed. Results. Data from 1474 patients were analyzed in our study cohort (hemangiopericytoma: ; hemangioendothelioma: ). The incidence of hemangioperi cytoma in 2016 was 0.060 per 100,000 individuals. The overall survival (OS) and cancer-specific survival (CSS) did not differ between patients with hemangioendothelioma and those with hemangiopericytoma (,). The tumor grade had no effect on the OS of hemangiopericytoma patients. Multivariate analysis revealed the clinical usefulness of surgery in hemangiopericytoma patients (, 95% confidence interval: 0.05-0.41, ). In contrast, radiotherapy did not improve OS () or CSS (), and chemotherapy worsened patient survival (). Additionally, the combination of surgery and radiotherapy had a similar effect with surgery alone on hemangiopericytoma patient survival (OS: ; CSS: ). Surgery plus chemotherapy provided a worse clinical benefit than surgery alone ().Conclusions. Our findings suggested that hemangiopericytoma had a similar prognosis with hemangioendothelioma. Surgery was the only effective treatment that provided survival benefits in hemangiopericytoma patients, while the clinical use fulness of adjuvant chemotherapy or radiotherapy was limited. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.