Expanding the phenotype of MOG antibody-associated disease (MOGAD): half a century of epilepsy and relapsing optic neuritis

Alexandros G.Sfakianakis shared this article with you from Inoreader Expanding the phenotype of MOG antibody-associated disease (MOGAD): half a century of epilepsy and relapsing optic neuritis Μέσω JNNP Online First Autoimmune disease has opened a field for the discovery of new phenotypes in clinical neurology. The unravelling of the autoimmune pathophysiology has led to successful novel treatment strategies including long-term immune suppression.1 In myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), damage to the central nervous system is attack related.2 The clinical phenotype of MOGAD is heterogenous and expanding. Here we illustrate a new phenomenon in a MOGAD-seropositive patient whom we have followed-up for 48 years: the synchronisation of relapsing, steroid responsive epilepsy and optic neuritis (ON). The long-term follow-up with repeated imaging, electrodiagnostic and laboratory tests of blood and cerebrospinal fluid permits to exclude with confidence that this phenotype is due to the more commonly described association of seizure activity with ON in acute encephalitis.3 The 69-year-old woman with relapsing ON reports the attacks to be often preceded by a cluster of seizures. Forty-eight years ago,... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.