Flow-Induced Transcriptomic Remodeling of Endothelial Cells Derived From Human Induced Pluripotent Stem Cells: The vascular system is essential for the development and function of all organs and tissues in our body. The molecular signature and phenotype of endothelial cells (EC) are greatly affected by blood flow-induced shear stress, which is a vital component of vascular development and homeostasis. Recent advances in differentiation of ECs from human induced pluripotent stem cells (hiPSC) have...
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Two Undervalued Functions of the Golgi Apparatus: Removal of Excess Ca2+ and Biosynthesis of Farnesol-Like Sesquiterpenoids, Possibly as Ca2+-Pump Agonists and Membrane "Fluidizers–Plasticizers": The extensive literature dealing with the Golgi system emphasizes its role in protein secretion and modification, usually without specifying from which evolutionary ancient cell physiological necessity such secretion originated. Neither does it specify which functional requirements the secreted proteins...
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Physical Exercise and the Renin Angiotensin System: Prospects in the COVID-19: Recent reports have shown that the renin angiotensin system (RAS) plays an important role in the Coronavirus disease 2019 (COVID-19) because the angiotensin converting enzyme 2 is the receptor for the severe acute respiratory syndrome coronavirus 2. In addition, the balance of RAS components can be involved in the pathogenesis and progression of COVID-19, especially in patients with metabolic and cardiovascular diseases....
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Functional Characterization of Facilitative Glucose Transporter 4 With a Delay Responding to Plasma Glucose Level in Blunt Snout Bream (Megalobrama amblycephala): Facilitative glucose transporter 4 (GLUT4) plays a central role in mediating insulin function to increase glucose uptake in glucose metabolism homeostasis. In this study, the function and localization of GLUT4 in blunt snout bream (Megalobrama amblycephala) were first investigated, and then, the response measured as carbohydrate level,...
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Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast: Skeletal muscle differentiation is an essential process for the maintenance of muscle development and homeostasis. Reactive oxygen species (ROS) are critical signaling molecules involved in muscle differentiation. Palmitoyl protein thioesterase 1 (PPT1), a lysosomal enzyme, is involved in removing thioester-linked fatty acid groups from modified cysteine residues in proteins. However, the role of PPT1...
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Remodeling of the Microvasculature: May the Blood Flow Be With You: The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands. Newly formed vascular plexuses during development are immature and require dynamic remodeling to generate well-patterned functional networks. This is achieved by remodeling of the capillaries preserving those which are functional and eliminating other ones. A balanced...
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Effect of Hyperbilirubinemia on Medial Olivocochlear System in Newborns.: PMC7419097J Int Adv Otol. 2020 Aug; 16(2): 295–296.doi: 10.5152/iao.2020.8592PMCID: PMC7419097PMID: 32784171Effect of Hyperbilirubinemia on Medial Olivocochlear System in NewbornsFulya ÖzerAuthor information Article notes Copyright and License information DisclaimerDepartment of Oto-Rhino-Laryngology and Head Neck Surgery, Başkent University School of Medicine, Ankara, TurkeyCorresponding author.Corresponding Address: Fulya...
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Preoperative assessment and optimization of cognitive dysfunction and frailty in the ambulatory surgical patient: Purpose of review The number and the complexity of procedures taking place at ambulatory surgery centers is steadily increasing. The rate at which medically complex patients, including those with baseline neurocognitive disorders, are undergoing ambulatory procedures is seeing a concurrent rise. Given the significant physical and psychological stress associated with surgery even in...
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High-risk surgical procedures and semi-emergent surgical procedures for ambulatory surgery: Purpose of review This review evaluates more complex surgical procedures to see whether they might be suitable for ambulatory surgery. Operations that have shown an increasing daycase rate in England include thyroidectomy, joint arthroplasty, spinal surgery and hysterectomy, and these procedures are evaluated. Similarly, there have been recent developments in the management of nonelective ambulatory surgery...
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Spinal anesthesia for ambulatory surgery: current controversies and concerns: Purpose of review General anesthesia is a popular choice for ambulatory surgery. Spinal anesthesia is often avoided because of perceived delays due to time required to administer it and prolonged onset, as well as concerns of delayed offset, which may delay recovery and discharge home. However, the reports of improved outcomes in hospitalized patients undergoing total joint arthroplasty have renewed the interest in spinal...
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Peripheral nerve blockade and novel analgesic modalities for ambulatory anesthesia: Purpose of review Despite peripheral nerve blockade offering analgesic benefits and improving patient satisfaction, it has not been well adopted in ambulatory anesthesia. In this review, we aim to summarize the evidence underlying peripheral nerve blockade, local anesthetic adjuncts, continuous peripheral nerve blockade and novel analgesic modalities, with the objective to provide recommendations on postoperative...
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Current state of noninvasive, continuous monitoring modalities in pediatric anesthesiology: Purpose of review The last decades, anesthesia has become safer, partly due to developments in monitoring. Advanced monitoring of children under anesthesia is challenging, due to lack of evidence, validity and size constraints. Most measured parameters are proxies for end organ function, in which an anesthesiologist is actually interested. Ideally, monitoring should be continuous, noninvasive and accurate....
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The Bowtie diagram: a simple tool for analysis and planning in anesthesia: Purpose of review The purpose is to show the advantages of a Bowtie diagram as a versatile tool for displaying and understanding the evolvement and management of critical incidents. Recent findings The Bowtie diagram has been used recently in anesthesia to depict critical incidents having been used in high-risk industries for several decades. This diagram displays the progression from latent factors to potential harm...
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Maternal safety: recent advances and implications for the obstetric anesthesiologist: Purpose of review Recognition of the increasing maternal mortality rate in the United States has been accompanied by intense efforts to improve maternal safety. This article reviews recent advances in maternal safety, highlighting those of particular relevance to anesthesiologists. Recent findings Cardiovascular and other chronic medical conditions contribute to an increasing number of maternal deaths. Anesthetic...
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Nulla Per Os (NPO) guidelines: time to revisit?: Purpose of review Preoperative fasting guidelines are generalized to elective procedures and usually do not distinguish between the ambulatory and inpatient setting. Prevalence of aspiration is low while prolonged preoperative fasting is common clinical reality. Recently, changes in preoperative fasting guidelines have been widely discussed. Recent findings Rates of prolonged clear fluid fasting (>4 h) prior to surgery are reported in up...
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Measuring and monitoring perioperative patient safety: a basic approach for clinicians: Purpose of review Recent research points to considerable rates of preventable perioperative patient harm and anaesthesiologists' concerns about eroding patient safety. Anaesthesia has always been at the forefront of patient safety improvement initiatives. However, factual local safety improvement requires local measurement, which may be afflicted by barriers to data collection and improvement activities. Because...
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Bacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis.: Related ArticlesBacteria-derived long chain fatty acid exhibits anti-inflammatory properties in colitis.Gut. 2020 Sep 25;:Authors: Pujo J, Petitfils C, Le Faouder P, Eeckhaut V, Payros G, Maurel S, Perez-Berezo T, Van Hul M, Barreau F, Blanpied C, Chavanas S, Van Immerseel F, Bertrand-Michel J, Oswald E, Knauf C, Dietrich G, Cani PD, Cenac NAbstract OBJECTIVE: Data from clinical research suggest that...
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Topic Application of the Probiotic Streptococcus dentisani Improves Clinical and Microbiological Parameters Associated With Oral Health.: Related ArticlesTopic Application of the Probiotic Streptococcus dentisani Improves Clinical and Microbiological Parameters Associated With Oral Health.Front Cell Infect Microbiol. 2020;10:465Authors: Ferrer MD, López-López A, Nicolescu T, Perez-Vilaplana S, Boix-Amorós A, Dzidic M, Garcia S, Artacho A, Llena C, Mira AAbstract Streptococcus dentisani...
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Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men.: Related ArticlesProbiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men.Hum Fertil (Camb). 2020 Sep 27;:1-9Authors: Helli B, Kavianpour M, Ghaedi E, Dadfar M, Haghighian HKAbstract Decreased sperm motility is one of the main causes of male infertility. The aim of this study was to evaluate the effects of probiotic...
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Effect of Limosilactobacillus reuteri LRE02-Lacticaseibacillus rhamnosus LR04 Combination on Antibiotic-Associated Diarrhea in a Pediatric Population: A National Survey.: Effect of Limosilactobacillus reuteri LRE02-Lacticaseibacillus rhamnosus LR04 Combination on Antibiotic-Associated Diarrhea in a Pediatric Population: A National Survey.J Clin Med. 2020 Sep 24;9(10):Authors: Drago L, Meroni G, Chiaretti A, Laforgia N, Cucchiara S, Baldassarre ME, On Behalf Of The Surveyflor GroupAbstract ...
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Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study.: Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study.Sci Rep. 2020 Sep 29;10(1):16004Authors: Higashikawa F, Kanno K, Ogata A, Sugiyama MAbstract Although large populations feel fatigue, the standardized medicinal...
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Lactobacillus plantarum KSFY06 and geniposide counteract montmorillonite-induced constipation in Kunming mice.: Lactobacillus plantarum KSFY06 and geniposide counteract montmorillonite-induced constipation in Kunming mice.Food Sci Nutr. 2020 Sep;8(9):5128-5137Authors: Gan Y, Liang J, Diao W, Zhou X, Mu J, Pang L, Tan F, Zhao XAbstract Constipation is a common clinical manifestation of digestive system disorders and occurs worldwide. This study investigated the ability of Lactobacillus...
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Impact of prebiotics on immune response: from the bench to the clinic.: Impact of prebiotics on immune response: from the bench to the clinic.Immunol Cell Biol. 2020 Sep 30;:Authors: Pujari R, Banerjee GAbstract Several preclinical and clinical studies have shown the immuno-modulatory role exerted by prebiotics in regulating immune response. In this review, we describe the mechanistic and clinical studies that decipher the cell signalling pathways implicated in the process. The prebiotic...
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Weissella cibaria CMU exerts an anti‑inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans‑induced NF‑κB activation in macrophages.: Weissella cibaria CMU exerts an anti‑inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans‑induced NF‑κB activation in macrophages.Mol Med Rep. 2020 Nov;22(5):4143-4150Authors: Kim MJ, You YO, Kang JY, Kim HJ, Kang MSAbstract Periodontitis is a chronic inflammatory disease caused by various periodontal pathogens. Weissella...
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Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves lipid profile, insulin sensitivity and gut microbiota diversity in dyslipidemic dams and protects male offspring against cardiovascular dysfunction in later life.: Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves lipid profile, insulin sensitivity and gut microbiota diversity in dyslipidemic dams and protects male offspring against cardiovascular dysfunction in later life.Food...
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Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: a randomized controlled trial.: Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: a randomized controlled trial.Clin Oral Investig. 2020 Oct 01;:Authors: Wattanarat O, Nirunsittirat A, Piwat S, Manmontri C, Teanpaisan R, Pahumunto N, Makeudom A, Sastraruji...
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Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.: Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.PLoS Pathog. 2020 Oct;16(10):e1008881Authors: Kamarajan P, Ateia I, Shin JM, Fenno JC, Le C, Zhan L, Chang A, Darveau R, Kapila YLAbstract Epidemiological...
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Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.
Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.: Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.Drug Dev Ind Pharm. 2020 Oct 02;:1-33Authors: Hoffmann A, Fischer JT, Daniels RAbstract OBJECTIVE: Probiotic bacteria, such as different lactobacilli strains, have successfully been used to treat gingivitis and periodontitis or caries. By formulating probiotics as orodispersible tablet (ODT),...
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Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.
Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.: Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion.Drug Dev Ind Pharm. 2020 Oct 02;:1-33Authors: Hoffmann A, Fischer JT, Daniels RAbstract OBJECTIVE: Probiotic bacteria, such as different lactobacilli strains, have successfully been used to treat gingivitis and periodontitis or caries. By formulating probiotics as orodispersible tablet (ODT),...
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota.: Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota.Gut Microbes. 2020 Nov 09;12(1):1-14Authors: Kim WK, Jang YJ, Han DH, Jeon K, Lee C, Han HS, Ko GAbstract Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis...
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Synbiotic Effects of Enzyme and Probiotics on Intestinal Health and Growth of Newly Weaned Pigs Challenged With Enterotoxigenic F18+ Escherichia coli.: Synbiotic Effects of Enzyme and Probiotics on Intestinal Health and Growth of Newly Weaned Pigs Challenged With Enterotoxigenic F18+ Escherichia coli.Front Vet Sci. 2020;7:573Authors: Duarte ME, Tyus J, Kim SWAbstract This study aimed to investigate the effect of dietary supplementation with xylanase and probiotics on growth performance...
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Efficacy of Spore Forming Bacilli Supplementation in Patients with Mild to Moderate Elevation of Triglycerides: A 12 week, Randomized, Double-Blind, Placebo Controlled Trial.: Efficacy of Spore Forming Bacilli Supplementation in Patients with Mild to Moderate Elevation of Triglycerides: A 12 week, Randomized, Double-Blind, Placebo Controlled Trial.Integr Med (Encinitas). 2020 Apr;19(2):22-27Authors: Campbell AW, Sinatra D, Zhang Z, Sinatra STAbstract Objective: The purpose of this randomized...
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Isolation and Characterization of Nitrate-Reducing Bacteria as Potential Probiotics for Oral and Systemic Health.: Isolation and Characterization of Nitrate-Reducing Bacteria as Potential Probiotics for Oral and Systemic Health.Front Microbiol. 2020;11:555465Authors: Rosier BT, Moya-Gonzalvez EM, Corell-Escuin P, Mira AAbstract Recent evidence indicates that the reduction of salivary nitrate by oral bacteria can contribute to prevent oral diseases, as well as increase systemic nitric oxide...
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Modulation of experimental autoimmune encephalomyelitis through colonisation of the gut with Escherichia coli.: Modulation of experimental autoimmune encephalomyelitis through colonisation of the gut with Escherichia coli.Benef Microbes. 2020 Oct 13;:1-16Authors: Libbey JE, Sanchez JMS, Fleming BA, Doty DJ, DePaula-Silva AB, Mulvey MA, Fujinami RSAbstract Multiple sclerosis (MS) is a neuro-inflammatory autoimmune disease of the central nervous system (CNS) that affects young adults. It is...
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The potential of Streptococcus salivarius oral films in the management of dental caries: an inkjet printing approach.: The potential of Streptococcus salivarius oral films in the management of dental caries: an inkjet printing approach.Int J Pharm. 2020 Oct 10;:119962Authors: Dodoo CC, Stapleton P, Basit AW, Gaisford SAbstract The use of probiotics, which can be administered in oro-dispersible films (ODFs) and have prolonged activity in the mouth was explored. ODFs made of xylitol and containing...
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MRI characterization of focal liver lesions in non-cirrhotic patients: assessment of added value of gadoxetic acid-enhanced hepatobiliary phase imaging: AbstractBackgroundTo evaluate the added value of the hepatobiliary (HPB) phase in gadoxetic acid-enhanced magnetic resonance imaging (MRI) in characterizing newly discovered indeterminate focal liver lesions in non-cirrhotic patients. ResultsOne-hundred and twenty-five non-cirrhotic patients (median age, 46 years; range, 20–85...
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Predictive value of a false-negative focused abdominal sonography for trauma (FAST) result in patients with confirmed traumatic abdominal injury: AbstractObjectiveTo investigate if patients with confirmed traumatic abdominal injury and a false-negative focused abdominal sonography for trauma (FAST) examination have a more favorable prognosis than those with a true-positive FAST. MethodsThis study included 97 consecutive patients with confirmed traumatic abdominal injury (based...
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Do we still need breast cancer screening in the era of targeted therapies and precision medicine?: AbstractBreast cancer (BC) is the most common female cancer and the second cause of death among women worldwide. The 5-year relative survival rate recently improved up to 90% due to increased population coverage and women's attendance to organised mammography screening as well as to advances in therapies, especially systemic treatments. Screening attendance is associated with a mortality reduction of...
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Multimodality imaging features of desmoid tumors: a head-to-toe spectrum: AbstractDesmoid tumors (DTs) are a rare and biologically heterogeneous group of locally aggressive fibroblastic neoplasm: their biological behavior spectrum ranges from indolent to aggressive tumors. DTs are classified as intra-abdominal, extra-abdominal, and within the abdominal wall lesions.It is well known that abdominal and extra-abdominal DTs are associated with familial adenomatous polyposis (FAP) and Gardner syndrome....
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Diagnostic accuracy of ultrasonography in the assessment of anterior knee pain: AbstractBackgroundAnterior knee pain (AKP) is a problematic complaint, considered to be the most frequent cause of orthopedic consultancy for knee problems. This study aimed to highlight diagnostic accuracy of ultrasonography as a fast imaging technique in assessment of patients with AKP. Methods and resultsA prospective study was conducted on 143 patients with clinically confirmed AKP. All patients...
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Sports-related lower limb muscle injuries: pattern recognition approach and MRI review: AbstractMuscle injuries of the lower limbs are currently the most common sport-related injuries, the impact of which is particularly significant in elite athletes. MRI is the imaging modality of choice in assessing acute muscle injuries and radiologists play a key role in the current scenario of multidisciplinary health care teams involved in the care of elite athletes with muscle injuries. Despite the frequency...
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Esophageal emergencies: another important cause of acute chest pain: AbstractA variety of esophageal pathologies can present emergently with a chief complaint of acute chest pain. Computed tomography (CT) is often the first line of imaging in esophageal emergencies and provides useful information—even without an initial suspicion—when used in conjunction with other imaging modalities such as esophagography and direct visualization. We review various urgent and emergent esophageal disease entities...
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Serum cystatin C: A potential predictor for hospital-acquired acute kidney injury in patients with acute exacerbation of COPD: Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. Hospital-acquired acute kidney injury (HA-AKI) is associated with poor prognosis. In this study, we evaluated whether serum cystatin C on admission could predict AKI in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The retrospective study was conducted using data on...
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Idiopathic Subglottic Stenosis: An Institutional Review of Outcomes With a Multimodality Surgical Approach.: Idiopathic Subglottic Stenosis: An Institutional Review of Outcomes With a Multimodality Surgical Approach.Otolaryngol Head Neck Surg. 2020 Oct 13;:194599820966978Authors: Dwyer CD, Qiabi M, Fortin D, Inculet RI, Nichols AC, MacNeil SD, Malthaner R, Yoo J, Fung KAbstract OBJECTIVES: This article reports on a unique cohort of patients with idiopathic subglottic stenosis spilt fairly...
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[New drug approval: Encorafenib-metastatic colorectal cancers with BRAF V600E mutation after systemic chemotherapy].: [New drug approval: Encorafenib-metastatic colorectal cancers with BRAF V600E mutation after systemic chemotherapy].Bull Cancer. 2020 Oct 09;:Authors: Boilève A, Samalin EPMID: 33046237 [PubMed - as supplied by publisher]
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Multicenter Evaluation of Breast Cancer Screening with Digital Breast Tomosynthesis in Combination with Synthetic versus Digital Mammography.: Multicenter Evaluation of Breast Cancer Screening with Digital Breast Tomosynthesis in Combination with Synthetic versus Digital Mammography.Radiology. 2020 Oct 13;:200240Authors: Zuckerman SP, Sprague BL, Weaver DL, Herschorn SD, Conant EFAbstract BackgroundDigital breast tomosynthesis (DBT) combined with digital mammography (DM) is increasingly...
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MRI of Skeletal Muscles in Participants with Type 2 Diabetes with or without Diabetic Polyneuropathy.: MRI of Skeletal Muscles in Participants with Type 2 Diabetes with or without Diabetic Polyneuropathy.Radiology. 2020 Oct 13;:192647Authors: Stouge A, Khan KS, Kristensen AG, Tankisi H, Schlaffke L, Froeling M, Væggemose M, Andersen HAbstract BackgroundDiabetic polyneuropathy (DPN) is associated with loss of muscle strength. MRI including diffusion-tensor imaging (DTI) may enable detection...
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Arterial Spin Labeling MRI in Carotid Stenosis: Arterial Transit Artifacts May Predict Symptoms.: Arterial Spin Labeling MRI in Carotid Stenosis: Arterial Transit Artifacts May Predict Symptoms.Radiology. 2020 Oct 13;:200225Authors: Di Napoli A, Cheng SF, Gregson J, Atkinson D, Markus JE, Richards T, Brown MM, Sokolska M, Jäger HRAbstract BackgroundStenosis of the internal carotid artery has a higher risk for stroke. Many investigations have focused on structure and plaque composition as...
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Early Treatment Effects of Nonablative Fractional Lasers (NAFL) on Hypertrophic Scars in an Animal Model: Background and ObjectivesRecently, there have been several attempts to apply the laser therapy to hypertrophic scars (HTS). In particular, the fractional laser is in the spotlight for its usefulness in rapid wound healing and dermal remodeling. However, most previous studies have focused on the ablative fractional laser (AFL), and there are no studies on the mechanism of the nonablative fractional...
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Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway.: Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway.Cancer Biol Ther. 2020 Oct 13;:1-11Authors: Huang XB, Song KJ, Chen GB, Liu R, Jiang ZF, He YLAbstract Cervical cancer (CC) is the second most common malignancy in women worldwide. The mechanism underlying CC development remains unclear....
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Apatinib and Camrelizumab in Recurrent or Metastatic Nasopharyngeal Carcinoma With First-line Treatment Failure: Conditions: Nasopharyngeal Carcinoma; Recurrent Nasopharyngeal Carcinoma; Metastatic Nasopharyngeal Carcinoma; Chemotherapy Effect; Immunotherapy; Molecular Targeted TherapyIntervention: Drug: Apatinib plus CamrelizumabSponsor: Sun Yat-sen UniversityRecruiting
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Programmed Cell Death 2-like (Pdcd2l) Is Required for Mouse Embryonic Development: Globozoospermia is a rare form of male infertility where men produce round-headed sperm that are incapable of fertilizing an oocyte naturally. In a previous study where we undertook a whole exome screen to define novel genetic causes of globozoospermia, we identified homozygous mutations in the gene PDCD2L. Two brothers carried a p.(Leu225Val) variant predicted to introduce a novel splice donor site, thus presenting...
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Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients with Relapsed Refractory Hodgkin Lymphoma: Purpose:Preclinical and early clinical data suggested that combining histone deacetylase (HDAC) and mTOR inhibitors can synergistically inhibit Hodgkin lymphoma.Patients and Methods:During the dose-escalation study (ClinicalTrials.gov number: NCT01087554) with the HDAC inhibitor vorinostat and the mTOR inhibitor sirolimus (V+S), a patient with Hodgkin lymphoma refractory to nine prior...
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FDA Approval Summary: Tucatinib for the Treatment of Patients with Advanced or Metastatic HER2-Positive Breast Cancer: On April 17, 2020, the FDA approved tucatinib in combination with trastuzumab and capecitabine for the treatment of patients with advanced unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting. This was the first new molecular entity evaluated under Project...
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A systematic evaluation of bioinformatics tools for identification of long noncoding RNAs [Article]: High-throughput RNA sequencing unveiled the complexity of transcriptome and significantly increased the records of long noncoding RNAs (lncRNAs) which were reported to participate in a variety of biological processes. Identification of lncRNAs is a key step of lncRNA analysis, and a bunch of bioinformatics tools have been developed for this purpose in recent years. While these tools allow us to identify...
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Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway.: Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway.Cancer Biol Ther. 2020 Oct 13;:1-11Authors: Huang XB, Song KJ, Chen GB, Liu R, Jiang ZF, He YLAbstract Cervical cancer (CC) is the second most common malignancy in women worldwide. The mechanism underlying CC development remains unclear....
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The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea: Authors Matossian C, Song X, Chopra I, Sainski-Nguyen A, Ogundele AReceived 1 August 2020Accepted for publication 17 September 2020Published 15 October 2020 Volume 2020:14 Pages 3371—3379DOI https://doi.org/10.2147/OPTH.S274949Checked for plagiarism YesReview by Single anonymous peer reviewPeer reviewer comments 3Editor who approved publication:...
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iStent Trabecular Micro-Bypass Stent Implantation with Cataract Surgery in a Japanese Glaucoma Population: Authors Nitta K, Yamada Y, Morokado S, Sugiyama KReceived 28 July 2020Accepted for publication 28 September 2020Published 15 October 2020 Volume 2020:14 Pages 3381—3391DOI https://doi.org/10.2147/OPTH.S274281Checked for plagiarism YesReview by Single anonymous peer reviewPeer reviewer comments 5Editor who approved publication: Dr Scott FraserKoji Nitta,1 Yutaro Yamada,1 Satomi Morokado,1 Kazuhisa...
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Optical Coherence Tomography Angiography Features of Neovascularization in Proliferative Diabetic Retinopathy: Sara Vaz-Pereira,1,2,* João Jesus Silva,2,* K Bailey Freund,3– 5 Michael Engelbert3– 51Department of Ophthalmology, Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria, Lisbon, Portugal; 2Department of Ophthalmology, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; 3Vitreous Retina Macula Consultants of New York, New York, NY, USA; 4LuEsther T....
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Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain: A recently deorphanized receptor, GPR18 showed to act with several endogenous cannaboinoid ligands. Among several potent functionalities the receptor activation also leads to the induction of anti‐infammatory and antinociceptive action. By using highly selective agonist of GPR18, PSB‐KK‐1415 we achieved an inflammation alleviation...
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18 F-FDG PET/CT versus anatomic imaging for evaluating disease extent and clinical trial eligibility in Erdheim-Chester disease: results from 50 patients in a registry study: AbstractObjectivesThe aim of this study was to [1] characterize distribution of Erdheim-Chester Disease (ECD) by 18F-FDG PET/CT and [2] determine the utility of metabolic (18F-FDG PET/CT) imaging versus anatomic imaging (CT or MRI) in evaluating ECD patients for clinical trial eligibility. Methods18F-FDG...
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Improved cancer detection in Waldeyer's tonsillar ring by 68 Ga-FAPI PET/CT imaging: AbstractPurposeIn cancer of unknown primary (CUP), positron emission tomography/computed tomography (PET/CT) with the glucose analog [18F]FDG represents the standard imaging approach for localization of the malignant primary. Frequently, however, [18F]FDG PET/CT cannot precisely distinguish between small occult tumors and chronic inflammation, especially in Waldeyer's tonsillar ring. To improve the accuracy for detecting...
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Microarchitecture of cetacean vertebral trabecular bone among swimming modes and diving behaviors: Cetacean vertebral trabecular bone volume fraction was greatest in rigid‐torso shallow divers, smallest in flexible‐torso deep divers, and intermediate in rigid‐torso deep divers. Degree of anisotropy was greater in rigid‐torso swimmers compared to their flexible‐torso counterparts. Despite having osteoporotic skeletons overall, cetacean vertebrae show greater bone volume fraction, trabecular thickness,...
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Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Thyroid Carcinomas with TERT Promoter Mutations: AbstractEpigenetic dysregulation is a hallmark of cancer, and aberrant methylation of cytosine residues plays a crucial role in abnormal gene expression in cancer cells. Recent studies demonstrate that 5-hydroxymethylcytosine (5-hmC) generated through 5-methylcytosine (5-mC) oxidation is significantly depleted in various cancers. However, whether 5-hmC levels change during the stepwise progression...
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pCLIF-SOFA is a reliable outcome prognostication score of critically ill children with cirrhosis: an ESPNIC multicentre study: Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensi...
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High doses of tigecycline are associated with satisfactory plasmatic and pulmonary concentrations for the treatment of severe infections due to fully susceptible bacteria: do we need even higher doses in patients under CRRT?:
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Tigecycline pharmacokinetics in critically ill patients on renal replacement therapy: possible warnings and potential perspectives for the research agenda:
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Persistent swallowing disorders after extubation in mechanically ventilated patients in ICU: a two-center prospective study: Persistent swallowing disorders (SD) are non-pulmonary complications of mechanical ventilation (MV). However, there are few clinical studies on persistent SD in critically ill patients undergoing tracheal intu...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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