A significant role of transcription factors E2F in inflammation and tumorigenesis of nasopharyngeal carcinoma.

ola Kala shared this article with you from Inoreader A significant role of transcription factors E2F in inflammation and tumorigenesis of nasopharyngeal carcinoma. Μέσω pubmed: small cell carcinoma... Related Articles A significant role of transcription factors E2F in inflammation and tumorigenesis of nasopharyngeal carcinoma. Biochem Biophys Res Commun. 2020 04 16;524(4):816-824 Authors: Liu P, Zhang X, Li Z, Wei L, Peng Q, Liu C, Wu Y, Yan Q, Ma J Abstract Nasopharyngeal carcinoma (NPC) is a malignant tumor from head and neck with characteristics in remarkable geographic and racial distribution worldwide, which has the important features of vigorous proliferation and inflammatory cells infiltration. By analyzing the expression profile data of NPC, we found that the E2F-related gene sets were highly enriched in NPC tissues. E2F transcription factor family is an important cycle regulator, which can promote the malignant proliferation and tumorigenesis. Here, we showed that E2Fs accelerated malignant phenotypes of NPC cells. RNA sequencing revealed that E2Fs can significantly up-regulate the inflammatory pathways in NPC cells. E2F1, as a transcription factor, can active the transcription activity of IL-6 promoter, and modulate macrophage function through a microenvironment manner. Thus, this study characterized a significant role of E2Fs in inflammation and tumorigenesis of NPC, which provided a promising anti-tumor target in NPC, since E2Fs are highly expressed and activated in NPC. PMID: 32044038 [PubMed - indexed for MEDLINE] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.