A prospective study of intraoperative assessment of mucosal squamous cell carcinoma margins in the head and neck.

gnorimies20.15 shared this article with you from Inoreader A prospective study of intraoperative assessment of mucosal squamous cell carcinoma margins in the head and neck. Via pubmed: "head neck"[jour] A prospective study of intraoperative assessment of mucosal squamous cell carcinoma margins in the head and neck. Head Neck. 2020 Oct 23;: Authors: Smithers FAE, Haymerle G, Palme CE, Low TH, Froggatt C, Gupta R, Clark JR Abstract BACKGROUND: In head and neck cancers, tumor margin assessment has important prognostic and therapeutic implications. Frozen section control of margins is commonly employed intraoperatively. However, this is not without limitations. The aim of this study is to determine whether intraoperative slicing of the whole specimen is feasible and what impact this may have on tumor margin assessment and the requirement for postoperative radiotherapy. METHODS: From September 2016 to August 2018, we recruited 22 patients as a pilot study looking at both the practicalities and the clinical relevance of whole margin tumor analysis intraoperatively. Our project is a prospective single arm study with historical controls. RESULTS: Forty-one percent of our patients required further intraoperative resection for close or involved margins. Seven of these patients who otherwise would have required adjuvant radiotherapy due to their margin status did not, after our intervention. CONCLUSIONS: We found that although requiring resources, this process was feasible without unduly increasing operative times and with potential patient benefit including reduced incidence of adjuvant radiotherapy. PMID: 33098251 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.