AntibodiesAntibodies, Vol. 9, Pages 46: Investig...
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OtoRhinoLaryngolgy News International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 6493: The Light and Shadow of Rapid Serological Tests for SARS-CoV-2 Infection: Results from a Study in a Large Emergency DepartmentIJERPH, Vol. 17, Pages 6493: The Light and Shadow of Rapid Serological Tests for SARS-CoV-2 Infection: Results from a Study in a Large Emergency Department International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17186493 Authors: Daniela Loconsole Francesca...
Mon Sep 07, 2020 08:17
Journal of the American Chemical Society: Latest Articles (ACS Publications)[ASAP] Next-Generation Total Synthesis of VancomycinJournal of the American Chemical SocietyDOI: 10.1021/jacs.0c07433Journal of the American Chemical Society: Latest Articles (ACS Publications)Fri Sep 04, 2020 07:00[ASAP] Imaging the Thermal Hysteresis of Single Spin-Crossover NanoparticlesJournal of the American Chemical SocietyDOI: 10.1021/jacs.0c05951Journal of the American Chemical Society: Latest Articles (ACS Publications)Fri...
Mon Sep 07, 2020 08:16
Journal of BiophotonicsThe use of photoacoustic imaging for monitoring vascular disrupting cancer treatmentsAbstract Vascular disrupting agents disrupt tumour vessels, blocking the nutritional and oxygen supply tumours need to thrive. This is achieved by damaging the endothelium lining of blood vessels, resulting in red blood cells (RBCs) entering the tumour parenchyma. RBCs present in the extracellular matrix are exposed to external stressors resulting in biochemical and physiological changes....
Mon Sep 07, 2020 08:16
CortexIntrinsic functional connectivity of the default mode and cognitive control networks relate to change in behavioral performance over two yearsPublication date: Available online 6 September 2020Source: CortexAuthor(s): Isabella A. Breukelaar, Kristi R. Griffiths, Anthony Harris, Sheryl L. Foster, Leanne M. Williams, Mayuresh S. KorgaonkarCortexSun Sep 06, 2020 21:565-year course of therapy-induced recovery in chronic non-fluent aphasia - Three single cases -Publication date: Available online...
Mon Sep 07, 2020 08:15
Low‐dose isotretinoin as a therapeutic option for dissecting cellulitisWiley: Dermatologic Therapy: Table of ContentsSat Sep 05, 2020 21:56Non‐inflammatory nodule formation after hyperdiluted Calcium Hydroxyapatite treatment in the neck areaWiley: Dermatologic Therapy: Table of ContentsSat Sep 05, 2020 21:55Methylene blue vs. methyl aminolevulinate photodynamic therapy in the treatment of mild‐to‐moderate toenail onychomycosis: short and medium‐term effectsABSTRACT Photodynamic therapy (PDT) has...
Mon Sep 07, 2020 08:14
Embryonal tumors of the central nervous system.Related Articles Embryonal tumors of the central nervous system. Curr Opin Oncol. 2020 Sep 02;: Authors: Pagès M, Masliah-Planchon J, Bourdeaut F Abstract PURPOSE OF REVIEW: This review aims to give an update on histopathological, molecular and clinical features of central nervous system (CNS) 'embryonal' tumors. RECENT FINDINGS: The taxonomy of previously called 'CNS primitive neuroectodermal tumor' (CNS PNET) has been deeply modified...Rare CancersSun...
Mon Sep 07, 2020 08:13
ContentsPublication date: October 2020Source: Clinics in Plastic Surgery, Volume 47, Issue 4Author(s):Plastic SurgeryFri Sep 04, 2020 16:22Unique Techniques or Approaches in Microvascular and Microlymphatic SurgeryPublication date: October 2020Source: Clinics in Plastic Surgery, Volume 47, Issue 4Author(s): Jin Bo Tang, Luis Landín, Pedro C. Cavadas, Alessandro Thione, Jing Chen, Gemma Pons, Jaume MasiàPlastic SurgeryFri Sep 04, 2020 16:22Maximizing the Utility of the Pedicled Anterolateral Thigh...
Mon Sep 07, 2020 08:12
A minimal yet flexible likelihood framework to assess correlated evolution [NEW RESULTS]An evolutionary process is reflected in the sequence of changes through time of any trait (e.g. morphological, molecular). Yet, a better understanding of evolution would be procured by characterizing correlated evolution, or when two or more evolutionary processes interact. A wide range of parametric methods have previously been proposed to detect correlated evolution but they often require significant computing...
Mon Sep 07, 2020 08:12
Enantioselective Total Synthesis of (‐)‐Finerenone using Asymmetric Transfer Hydrogenation(‐)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. Herein, we report a 6‐step synthesis of (‑)‐Finerenone which features an enantioselective partial transfer hydrogenation of a naphthyridine using a chiral phosphoric acid catalyst with a...
Mon Sep 07, 2020 08:11
Biomedicine & PharmacotherapyFetuin B overexpression suppresses proliferation, migration, and invasion in prostate cancer by inhibiting the PI3K/AKT signaling pathwayPublication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Kai Zhan, Rui Liu, Hang Tong, Shun Gao, Guang Yang, Arman Hossain, Tinghao Li, Weiyang HeBiomedicine & PharmacotherapySat Sep 05, 2020 21:28Metabolic profiling, <em>in vitro</em> bioaccessibility and <em>in vivo</em>...
Mon Sep 07, 2020 08:10
DysphagiaA Preliminary Investigation of Whether HRCA Signals Can Differentiate Between Swallows from Healthy People and Swallows from People with Neurodegenerative DiseasesAbstract High-resolution cervical auscultation (HRCA) is an emerging method for non-invasively assessing swallowing by using acoustic signals from a contact microphone, vibratory signals from an accelerometer, and advanced signal processing and machine learning techniques. HRCA has differentiated between safe and unsafe swallows,...
Mon Sep 07, 2020 08:09
Acta Cirurgica BrasileiraPrevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal modelAbstract Purpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological...
Mon Sep 07, 2020 08:09
BMC Research NotesPerioperative hemoglobin decrement as an independent risk of poor early graft function in kidney transplantationPerioperative change of hemoglobin concentration (Hb) was associated with acute kidney injury in patients who underwent non-cardiac surgery, but has never been investigated in kidney transplant patients. This ...BMC Research NotesSat Sep 05, 2020 03:00An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic...
Mon Sep 07, 2020 08:08
Prevention of brain metastases in human epidermal growth factor receptor 2-positive breast cancer.Related Articles Prevention of brain metastases in human epidermal growth factor receptor 2-positive breast cancer. Curr Opin Oncol. 2020 Sep 02;: Authors: Eberst L, Bailleux C, Bachelot T Abstract PURPOSE: For patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, treatments that could prevent or delay occurrence of brain metastases would improve outcome. RECENT FINDINGS:...
Mon Sep 07, 2020 08:08
pubmed: basal ganglia stroke...Elevated miR-29a Contributes to Axonal Outgrowth and Neurological Recovery After Intracerebral Hemorrhage via Targeting PTEN/PI3K/Akt Pathway.Related Articles Elevated miR-29a Contributes to Axonal Outgrowth and Neurological Recovery After Intracerebral Hemorrhage via Targeting PTEN/PI3K/Akt Pathway. Cell Mol Neurobiol. 2020 Sep 05;: Authors: Zhao M, Gao J, Zhang Y, Jiang X, Tian Y, Zheng X, Wang K, Cui J Abstract Spontaneous intracerebral hemorrhage (ICH) is a clinical...
Mon Sep 07, 2020 08:07
oral surg oral medOral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?Related Articles Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Aug 18;: Authors: Brandão TB, Gueiros LA, Melo TS, Prado-Ribeiro AC, Nesrallah ACFA, Prado GVB, Santos-Silva AR, Migliorati CA Abstract Several viruses transmitted through saliva, such as herpes simplex virus, cytomegalovirus, and...
Mon Sep 07, 2020 08:06
NanomaterialsNanomaterials, Vol. 10, Pages 1741: Dynamics and Applications of Photon-Nanostructured SystemsNanomaterials, Vol. 10, Pages 1741: Dynamics and Applications of Photon-Nanostructured Systems Nanomaterials doi: 10.3390/nano10091741 Authors: Evangelia Sarantopoulou In a speedy and complicated word, only a small number of book readers have the time to dig out the hidden "gemstones" between the text lines [...]Nanomaterials03:00Σήμανση της παραπάνω ενότητας ως αναγνωσμένης BiosensorsBiosensors,...
The Journal of PhysiologyRebuttal from Francisco J. Alvarez‐LeefmansThe Journal of PhysiologyTue Sep 01, 2020 16:55Neurovascular coupling: sending this signal here, hope you pick it up loud and clearThe Journal of PhysiologyTue Sep 01, 2020 13:30Mark above section as read Journal of Evolutionary BiologyWithin‐population variation in female mating preference affects the opportunity for sexual selection and the evolution of male traits, but things are not as simple as expectedAbstract Females from...
Journal of Endocrinological InvestigationMesenchymal stem cells-originated exosomal microRNA-152 impairs proliferation, invasion and migration of thyroid carcinoma cells by interacting with DPP4Abstract Background Thyroid carcinoma (THCA) is the most prevalent tumor in the endocrine system with an increasing incidence. Recent studies have underscored the function of microRNAs (miRNAs) in THCA. Nevertheless, knowledge regarding the effects of exosomal miRNAs in THCA is still limited. This report...
International journal of basic and clinical endocrinologyMeta-analytic evidence for increased low-grade systemic inflammation and oxidative stress in hypothyroid patients. Can levothyroxine replacement therapy mitigate the burden?Abstract Purpose This series of meta-analyses were aimed to elucidate the impact of hypothyroidism on low-grade systemic inflammation and oxidative stress assessed by C-reactive protein (CRP) and malondialdehyde (MDA) respectively; and to evaluate the effect of levothyroxine...
bioRxiv Subject Collection: Evolutionary BiologyWhen the microbiome defines the host phenotype: selection on vertical transmission in varying environments [NEW RESULTS]The microbiome can contribute to variation in fitness-related traits of their hosts, and thus to host evolution. Hosts are therefore expected to be under selection to control their microbiome, for instance through controlling microbe transmission from parents to offspring. Current models have mostly focused on microbes that either...
Bench Testing of a Bubble Noninvasive Ventilation Device in an Infant Lung SimulatorBACKGROUND:Infant respiratory distress remains a significant problem worldwide, leading to more than one million neonatal deaths each year. The cost, maintenance, energy, and personnel required to implement ventilators have proven to be a barrier in many resource-limited settings. To address these barriers, a nonelectric bubble noninvasive positive pressure ventilation (NIV) device was developed. This study aims...
Clinical decision making in small non-functioning VHL-related incidentalomas.Related Articles Clinical decision making in small non-functioning VHL-related incidentalomas. Endocr Connect. 2020 Aug;9(8):834-844 Authors: Därr R, Kater J, Sekula P, Bausch B, Krauss T, Bode C, Walz G, Neumann HP, Zschiedrich S Abstract The optimal treatment strategy for patients with small non-functioning VHL-related incidentalomas is unclear. We searched the Freiburg VHL registry for patients with radiologic evidence...
Nature Communications - current - nature.com science feedsAccurate quantification of copy-number aberrations and whole-genome duplications in multi-sample tumor sequencing dataNature Communications, Published online: 02 September 2020; doi:10.1038/s41467-020-17967-yThe correct identification of copy-number aberrations (CNAs) in tumours can provide information for diagnosis, prognosis and therapeutic strategies. Here, the authors provide an algorithm, HATCHet, which quantifies CNAs using multiple...
Clinical Oral Implants ResearchComparison of a polyethylene glycol membrane and a collagen membrane for the treatment of bone dehiscence defects at bone level implants ‐ a prospective, randomized, controlled, multicenter clinical trialAbstract Objectives The aim of the present randomized, controlled clinical multicenter trial was to compare a polyethylenglycol (PEG) and a native collagen membrane (BG) for simultaneous guided bone regeneration (GBR) at bony dehiscence‐type defects around bone level...
Clinical Neurology and NeurosurgeryTherapeutic anticoagulation for venous thromboembolism after recent brain surgery: evaluating the risk of intracranial hemorrhagePublication date: Available online 1 September 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): José Orlando de Melo, Márcia Aparecida Lodi Campos Melo, Luiz Antônio da Silva Lavradas, Plínio Gabriel Ferreira Lopes, Ingra Ianne Luiz Ornelas, Paula Lacerda de Barros, Paulo José da Mata Pereira, Paulo Niemeyer FilhoClinical Neurology...
Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)Dual-recognition-based determination of ctDNA via the clamping function of peptide nucleic acid and terminal protection of small-molecule-linked DNAAnalyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01305F, PaperChaohui Chen, Rongxiang He, Zhengtao Zhang, Yong ChenA new dual-recognition fluorescent biosensor for circulating tumor DNA (ctDNA) detection has been developed, which combines...
Allergology InternationalPlasma miR223 is a possible biomarker for diagnosing patients with severe atopic dermatitisPublication date: Available online 1 September 2020Source: Allergology InternationalAuthor(s): Risa Yasuike, Risa Tamagawa-Mineoka, Naomi Nakamura, Koji Masuda, Norito KatohAllergology InternationalWed Sep 02, 2020 17:44Mark above section as read AllergyPersonalized Medicine for allergy treatment: allergen immunotherapy still a unique and unmatched modelAbstract The introduction of...
Diagnostic CytopathologyConditions associated with the need for additional needle passes in ultrasound‐guided thyroid fine‐needle aspiration with rapid on‐site pathology evaluationAbstract Background Rapid on‐site evaluation (ROSE) is a valuable tool for specimen adequacy assessment in thyroid ultrasound (US)‐guided fine‐needle aspiration (US‐guided FNA). To reduce the risk of nondiagnostic samples, additional needle passes may be needed at ROSE to ensure adequate sampling. Recommendations regarding...
ANZ Journal of SurgeryEn bloc resection of locally perforated colonic malignancy with removal of iliopsoas and femoral nerve and primary anastomosisANZ Journal of SurgeryTue Sep 01, 2020 20:45How to repair a small umbilical hernia laparoscopicallyWe describe a step by step technique for repair of a small umbilical hernia laparoscopically that aims to provide an excellent technical and cosmetic result without a significant increase in operative time or cost. Patients report good quality of life...
Asymmetric Transformation Driven by Confinement and Self‐Release in Single‐Layered Porous NanosheetAsymmetric transformation requires the use of chiral catalysts which is hampered by energy intensive processes such as high cost, inefficient recycle, and tedious separation. Here we report the use of single‐layered, chiral porous sheets with induced pore chirality for repeatable asymmetric transformation and self‐separation without the need of chiral catalysts or chiral auxiliaries. The asymmetric...
Biomedicine & PharmacotherapyChlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 <em>in vitro</em> and <em>in vivo</em>Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Lei Wang, Hongwu Du, Peng ChenBiomedicine & PharmacotherapyWed Sep 02, 2020 18:10Ruboxistaurin maintains the bone mass of subchondral bone for blunting osteoarthritis progression by inhibition of osteoclastogenesis...
Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell LinesBackground/Aim: Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated cholangiocarcinoma (CCA) remains unclear. This study aimed to investigate the antitumor activity of shikonin, a PKM2 inhibitor, in CCA cells. Materials and Methods: Immunohistochemistry and immunoblotting were used to determine PKM2 expression in CCA tissues...
Acta Otorrinolaringológica EspañolaPrimary stapedotomy: Influence of prosthesis diameter on hearing outcomePublication date: Available online 2 September 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Pedro Salvador, Ricardo Costa, Francisco Silva, Rui FonsecaActa Otorrinolaringológica EspañolaWed Sep 02, 2020 15:14Mark above section as read Auris Nasus LarynxCarotid blowout—a rare but fatal complication of endoscopic submucosal dissection of superficial hypopharyngeal carcinoma after...
pubmed: epilepsy treatmentThe mystery of the ketogenic diet: benevolent pseudo-diabetes.Related Articles The mystery of the ketogenic diet: benevolent pseudo-diabetes. Cell Cycle. 2019 09;18(18):2157-2163 Authors: Blagosklonny MV Abstract Designed a century ago to treat epilepsy, the ketogenic diet (KD) is also effective against obesity and diabetes. Paradoxically, some studies in rodents have found that the KD seemingly causes diabetes, contradicting solid clinical data in humans. This paradox...
OncologyAn observational study of drug utilization and associated outcomes among adult patients diagnosed with BRAF-mutant advanced melanoma treated with first-line anti-PD-1 monotherapies or BRAF/MEK inhibitors in a community-based oncology setting.Related Articles An observational study of drug utilization and associated outcomes among adult patients diagnosed with BRAF-mutant advanced melanoma treated with first-line anti-PD-1 monotherapies or BRAF/MEK inhibitors in a community-based oncology...
anesth pain medPharmacokinetics of lidocaine after bilateral ESP block.Related Articles Pharmacokinetics of lidocaine after bilateral ESP block. Reg Anesth Pain Med. 2020 Aug 31;: Authors: De Cassai A, Bonanno C, Padrini R, Geraldini F, Boscolo A, Navalesi P, Munari M Abstract INTRODUCTION: Erector spinae plane (ESP) block is an emerging interfascial block with a wide range of indications for perioperative analgesia and chronic pain treatment. Recent studies have focused their attention on mechanisms...
Academic RadiologyHighly Accelerated Real-Time Free-Breathing Cine CMR for Patients With a Cardiac Implantable Electronic DevicePublication date: Available online 2 September 2020Source: Academic RadiologyAuthor(s): Sungtak Hong, KyungPyo Hong, Austin E. Culver, Ashitha Pathrose, Bradley D. Allen, Jane E. Wilcox, Daniel C. Lee, Daniel KimAcademic RadiologyWed Sep 02, 2020 17:56Mark above section as read European Journal of Nuclear Medicine and Molecular ImagingLong-term outcome of "Sandwich" chemo-PRRT:...
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