Melatonin in flowering, fruit set and fruit ripening.: Related ArticlesMelatonin in flowering, fruit set and fruit ripening.Plant Reprod. 2020 Apr 06;:Authors: Arnao MB, Hernández-Ruiz JAbstract KEY MESSAGE: Melatonin induces a delay in flowering stabilizing DELLA proteins and also promotes the transcription of FLC. In fruit set, melatonin is able to induce parthenocarpy. Melatonin promotes ripening and retards senescence of fruits. Melatonin is an animal hormone involved in many regulatory...
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Prevalence and predictors of mood disturbances in idiopathic REM sleep behaviour disorder.: Related ArticlesPrevalence and predictors of mood disturbances in idiopathic REM sleep behaviour disorder.J Sleep Res. 2020 Apr 07;:e13040Authors: Chiu NKH, Ehgoetz Martens KA, Mok VCT, Lewis SJG, Matar EAbstract Depression and anxiety are commonly associated with synucleinopathies. Mood disturbances have also been reported in patients with idiopathic REM sleep behaviour disorder (iRBD) and are difficult...
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A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma.: Related ArticlesA Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma.Am J Respir Crit Care Med. 2020 Apr 07;:Authors: Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GLAbstract BACKGROUND: MicroRNAs are potent regulators of biologic systems that are critical...
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The Bronchiectasis in COPD-OSA Overlap Syndrome Patients.: Related ArticlesThe Bronchiectasis in COPD-OSA Overlap Syndrome Patients.Int J Chron Obstruct Pulmon Dis. 2020;15:605-611Authors: Yang X, Tang X, Cao Y, Dong L, Wang Y, Zhang J, Cao JAbstract Purpose: COPD-OSA (chronic obstructive pulmonary disease-obstructive sleep apnea) overlap syndrome is associated with more frequent COPD acute exacerbations than COPD without OSA. With the application of high-resolution computed tomography (HRCT)...
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Novel AHDC1 Gene Mutation in a Brazilian Individual: Implications of Xia-Gibbs Syndrome.: Related ArticlesNovel AHDC1 Gene Mutation in a Brazilian Individual: Implications of Xia-Gibbs Syndrome.Mol Syndromol. 2020 Feb;11(1):24-29Authors: Cardoso-Dos-Santos AC, Oliveira Silva T, Silveira Faccini A, Woycinck Kowalski T, Bertoli-Avella A, Morales Saute JA, Schuler-Faccini L, de Oliveira Poswar FAbstract Xia-Gibbs syndrome (XGS) is a rare neurological disorder characterized by global developmental...
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Extending the Phenotypic Spectrum of Huntington Disease: Hypothermia.: Related ArticlesExtending the Phenotypic Spectrum of Huntington Disease: Hypothermia.Mol Syndromol. 2020 Feb;11(1):56-58Authors: Altıner Ş, Ardic S, Çebi AHAbstract Huntington disease (HD) is an autosomal dominant progressive neurodegenerative disorder associated with expanded CAG repeat size in the huntingtin gene and usually presenting with movement disorder, psychiatric symptoms, and cognitive decline. Sleep problems,...
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Measuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function.: Related ArticlesMeasuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function.Front Hum Neurosci. 2020;14:69Authors: Marchi V, Stevenson N, Koolen N, Mazziotti R, Moscuzza F, Salvadori S, Pieri R, Ghirri P, Guzzetta A, Vanhatalo SAbstract Early nutritional compromise after preterm birth is shown to affect long-term neurodevelopment, however, there has been a lack of early functional...
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Lucid Dreaming, Nightmares, and Sleep Paralysis: Associations With Reality Testing Deficits and Paranormal Experience/Belief.: Related ArticlesLucid Dreaming, Nightmares, and Sleep Paralysis: Associations With Reality Testing Deficits and Paranormal Experience/Belief.Front Psychol. 2020;11:471Authors: Drinkwater KG, Denovan A, Dagnall NAbstract Focusing on lucid dreaming, this paper examined relationships between dissociated experiences related to rapid eye movement (REM) sleep (lucid dreaming,...
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The Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.: Related ArticlesThe Broad Concept of "Spasticity-Plus Syndrome" in Multiple Sclerosis: A Possible New Concept in the Management of Multiple Sclerosis Symptoms.Front Neurol. 2020;11:152Authors: Fernández Ó, Costa-Frossard L, Martínez-Ginés M, Montero P, Prieto JM, Ramió LAbstract Multiple sclerosis (MS) pathology progressively affects multiple central...
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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study.: Related ArticlesEffect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study.Case Rep Neurol Med. 2020;2020:8597062Authors: Sripad P, Rosenberg J, Boers F, Filss CP, Galldiks N, Langen KJ, Clauss R, Shah NJ, Dammers JAbstract In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness...
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Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant.: Related ArticlesAcquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant.Case Rep Pediatr. 2020;2020:5740304Authors: Lim AYL, Mattke AC, Clark JE, Pinzon-Charry A, Alphonso N, Kapur NAbstract Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia...
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Cavitary Pneumonia: A Complication of Antibiotic Noncompliance.: Related ArticlesCavitary Pneumonia: A Complication of Antibiotic Noncompliance.Case Rep Pulmonol. 2020;2020:5971348Authors: Cotton JL, Ali-Dinar T, Navas-Nazario AAbstract In this report, we present a complicated case of community-acquired pneumonia in a 5-year-old boy. The patient first presented to the pulmonology clinic with the diagnosis of asthma and a recent history of recurrent pneumonia. Poor compliance to two courses...
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Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update.: Related ArticlesRapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update.Aging Dis. 2020 Apr;11(2):315-326Authors: Zhang F, Niu L, Liu X, Liu Y, Li S, Yu H, Le WAbstract Rapid eye movement sleep behavior disorder (RBD) is a sleep behavior disorder characterized by abnormal behaviors and loss of muscle atonia during rapid eye movement (REM) sleep. RBD is generally considered to...
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Flaccid Paralysis with Hyponatremia: Think Guillain-Barre Syndrome.: Related ArticlesFlaccid Paralysis with Hyponatremia: Think Guillain-Barre Syndrome.Cureus. 2020 Feb 27;12(2):e7113Authors: Griffin D, Asad H, Patel P, Gohar AAbstract Guillain-Barre syndrome (GBS) is the most common cause of flaccid paralysis in affected patients. Here we present a case of GBS presenting with flaccid paralysis as well as hyponatremia. The association of hyponatremia in GBS is discussed, as well as other...
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Landau-Kleffner Syndrome: A Diagnostic Challenge.: Related ArticlesLandau-Kleffner Syndrome: A Diagnostic Challenge.Cureus. 2020 Mar 05;12(3):e7182Authors: Ahmed M, Saleem A, Nasir S, Ariff M, Iftikhar PAbstract The Landau-Kleffner syndrome (LKS), formerly known as acquired epileptic aphasia, is a rare syndrome that typically presents in early childhood with language regression and seizures. We report a case of LKS in an 7-year-old boy who presented with aggressive behavior, difficulty in...
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Multiple pulmonary nodules in granulomatous polyangiitis: A case series.: Related ArticlesMultiple pulmonary nodules in granulomatous polyangiitis: A case series.Respir Med Case Rep. 2020;30:101043Authors: Arunsurat I, Reechaipichitkul W, So-Ngern A, Chaisuriya N, Mahankkanukrauh A, Ratanawatkul P, Chumpangern W, Kampan PAbstract Granulomatous polyangiitis (GPA) is a multiple systemic necrotizing vasculitis. Diagnosis of pulmonary nodules in GPA is still challenging in clinical practice,...
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Oral ethinyl estradiol treatment in women with cystic fibrosis is associated with lower bone mineral density.: Related ArticlesOral ethinyl estradiol treatment in women with cystic fibrosis is associated with lower bone mineral density.J Clin Transl Endocrinol. 2020 Jun;20:100223Authors: Wu M, Hunt WR, Putman MS, Tangpricha VAbstract Objective: The purpose of this study was to determine whether estrogen supplementation primarily from oral contraceptive pills compared to no estrogen supplementation...
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Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia.: Related ArticlesDouble-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia.World J Psychiatry. 2020 Mar 19;10(3):21-28Authors: Dowd SM, Zalta AK, Burgess HJ, Adkins EC, Valdespino-Hayden...
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The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease.: Related ArticlesThe Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease.Front Cell Infect Microbiol. 2020;10:104Authors: Askarova S, Umbayev B, Masoud AR, Kaiyrlykyzy A, Safarova Y, Tsoy A, Olzhayev F, Kushugulova AAbstract Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy...
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Recurrent Wheezing in Pre-school Age: Not Only Airway Reactivity!: Related ArticlesRecurrent Wheezing in Pre-school Age: Not Only Airway Reactivity!Front Pediatr. 2020;8:101Authors: Roversi M, Porcaro F, Francalanci P, Carotti A, Cutrera RAbstract Background: About a fifth of all mediastinal masses are primary cysts arising in the absence of other underlying pathology. Bronchogenic cysts, although rare, are the most frequent type responsible for lower airways compression as they often develop...
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Acute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid.: Related ArticlesAcute sleep deprivation during pregnancy in rats: Rapid elevation of placental and fetal inflammation and kynurenic acid.Neurobiol Stress. 2020 May;12:100204Authors: Baratta AM, Kanyuch NR, Cole CA, Valafar H, Deslauriers J, Pocivavsek AAbstract The kynurenine pathway (KP) is the dominant pathway for tryptophan degradation in the mammalian body and emerging...
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Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study.: Related ArticlesEffect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study.Crit Care Explor. 2020 Mar;2(3):e0085Authors: Schomer KJ, Duby JJ, Firestone RL, Louie EL, Sebat CM, Love DM, Cocanour CS, Albertson TEAbstract To determine whether the use of flumazenil reverses hypoactive delirium and increases delirium-free days in critically ill patients...
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Association Between Medicare Expenditures and Adverse Events for Patients With Acute Myocardial Infarction, Heart Failure, or Pneumonia in the United States.: Related ArticlesAssociation Between Medicare Expenditures and Adverse Events for Patients With Acute Myocardial Infarction, Heart Failure, or Pneumonia in the United States.JAMA Netw Open. 2020 Apr 01;3(4):e202142Authors: Wang Y, Eldridge N, Metersky ML, Sonnenfeld N, Rodrick D, Fine JM, Eckenrode S, Galusha DH, Tasimi A, Hunt DR, Bernheim...
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Alcohol and Parasomnias: The Statistical Evaluation of the Parasomnia Defense in Sexual Assault, Where Alcohol is Involved.: Related ArticlesAlcohol and Parasomnias: The Statistical Evaluation of the Parasomnia Defense in Sexual Assault, Where Alcohol is Involved.J Forensic Sci. 2020 Apr 07;:Authors: Munro NAAbstract Sleep sex may be a defense for alleged sexual assault. The International Classification of Sleep Disorders (ICSD3) states: "Disorders of arousal should not be diagnosed in the...
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Novel Insights into Smell and Taste Sensitivity in Normal Weight and Overweight-Obese Adolescents.: Related ArticlesNovel Insights into Smell and Taste Sensitivity in Normal Weight and Overweight-Obese Adolescents.Physiol Behav. 2020 Apr 04;:112897Authors: Herz RS, Van Reen E, Gredvig-Ardito CA, Carskadon MAAbstract Research examining connections between BMI and smell and taste sensitivity in adolescents has been minimal, methodologically inconsistent, and inconclusive. We sought to address...
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Associations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies.: Related ArticlesAssociations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies.Sleep Med Rev. 2020 Mar 17;52:101307Authors: Dunietz GL, Vanini G, Shannon C, O'Brien LM, Chervin RDAbstract The hypocretin system consists of two peptides hypocretin-1 and hypocretin-2 (HCRT1 and HCRT2). Hypocretin-containing neurons are...
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A novel extrapolation method using OSL detectors for very small field output factor measurement for stereotactic radiosurgery: AbstractAppropriate methods for the determination of very small X-ray beam output factors are essential to ensure correct clinical outcomes for stereotactic radiosurgery. To date, substantial work has been performed in identifying and quantifying suitable dosimeters for relative output factor (ROF) measurements including recent IAEA published recommendations. In this work,...
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Weekly paclitaxel plus bevacizumab versus docetaxel as second- or third-line treatment in advanced non-squamous non–small-cell lung cancer: Results of the IFCT-1103 ULTIMATE study: Publication date: May 2020Source: European Journal of Cancer, Volume 131Author(s): Alexis B. Cortot, Clarisse Audigier-Valette, Olivier Molinier, Sylvestre Le Moulec, Fabrice Barlesi, Gérard Zalcman, Patrick Dumont, Damien Pouessel, Claire Poulet, Clara Fontaine-Delaruelle, Sandrine Hiret, Adrien Dixmier, Patrick-Aldo...
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Associations of whole blood polyunsaturated fatty acids and insulin resistance among European children and adolescents: AbstractThis study aims to examine the association of whole blood n-3 and n-6 polyunsaturated fatty acids (PUFA) with insulin resistance (IR) in children. Whole blood fatty acids were measured in 705 children aged 2–9 years of the European IDEFICS/I.Family cohort using gas chromatography in units of weight percentage of all detected fatty acids (%wt/wt). IR was determined by the...
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Cholecystokinin (CCK) level is higher among first time suicide attempters than healthy controls, but is not associated with higher depression scores: Suicide and suicide attempts are dramatic events for both the individuals concerned and for their social environments. Efforts have been made to identify reliable biological predictors of suicide and suicide attempts. In the present study, we focused on one potential marker, cholecystokinin (CCK), among first time suicide attempters. A total of 25 suicide...
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Cortisol Impacted on Explicit Learning Encoding, but Not on Storage and Retrieval, and Was Not Associated With Sleep Patterns-Results From the Trier Social Stress Test for Children (TSST-C) Among 9-Years Old Children: Background:; Learning is the relatively permanent change of behavior as a result of experience and tightly related to memory and cognition. Learning is particularly important for children. Further, restoring sleep is associated both with improved learning performance and lower cortisol...
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Influence of adjuvant omega-3-polyunsaturated fatty acids on depression, sleep, and emotion regulation among outpatients with major depressive disorders - Results from a double-blind, randomized and placebo-controlled clinical trial: Extant literature shows that adjuvant omega-3-polyunsaturated fatty acids (O3PUFAs) to a standard antidepressant medication impacts favorably on symptoms of depression in participants with major depressive disorders (MDD). The aim of the present study was to investigate,...
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Prospective Validation of a Biomarker-Based Rule Out Strategy for Functionally Relevant Coronary Artery Disease: This study aimed to prospectively advance a rule-out strategy for functionally significant coronary artery disease (CAD) by use of high-sensitivity cardiac troponin I (hs-cTnI) from bench to bedside, by application of a 3-step approach: validation in serum, correlation in plasma, and application on a clinical platform.; Patients without known CAD referred for rest/stress myocardial perfusion...
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Combining high-sensitivity cardiac troponin and B-type natriuretic peptide in the detection of inducible myocardial ischemia: Single biomarker approaches provide only moderate accuracy in the non-invasive detection of exercise-induced myocardial ischemia. We therefore assessed the combination of the two most promising single biomarkers: high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP).; Consecutive patients with suspected myocardial ischemia referred to stress myocardial...
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Direct Comparison of Cardiac Troponin T and I Using a Uniform and a Sex-Specific Approach in the Detection of Functionally Relevant Coronary Artery Disease: We aimed to directly compare high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the detection of functionally relevant coronary artery disease (fCAD).; Consecutive patients referred with clinical suspicion of fCAD and no structural heart disease other than coronary artery disease were included....
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Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope: It is unknown whether cardiac syncope, and possibly also other syncope aetiologies exhibit circadian, weekly, seasonal, and temperature-dependent patterns.; We prospectively recorded the exact time, date, and outside temperature of syncope of patients >40 years old presenting with syncope to the emergency department in a diagnostic multicentre study. Two independent...
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Auditory cortical processing in cochlear-implanted children with different language outcomes: AbstractPurposeBehavioral evaluation of language development is an important index for the usefulness of cochlear implantation. However, it could not apply to infants and very young children. It is useful to adopt an objective measure to examine speech discrimination in this population. Thus, the current study aimed to predict the different behavioral language performance (good versus poor) in cochlear implant...
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Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
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Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Amy I. Yu, Lili Zhao, Kathryn A. Eaton, Sharon Ho, Jiachen Chen, Sara Poe, James Becker, Allison Gonzalez, Delaney McKinstry, Muneer Hasso, Jonny Mendoza-Castrejon, Joel Whitfield, Charles Koumpouras, Patrick D. Schloss, Eric C. Martens, Grace Y. Chen
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Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Santosh K. Mishra, Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, Patrick Ralph, Jacob Coyne, Michelle Parkington, Jennifer DeBrecht, Lauren C. Ehrhardt-Humbert, Glenn P. Cruse, Wolfgang Bäumer, Ru-Rong Ji, Mei-Chuan Ko, Thierry Olivry
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Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Nathan A. Dahl, Etienne Danis, Ilango Balakrishnan, Dong Wang, Angela Pierce, Faye M. Walker, Ahmed Gilani, Natalie J. Serkova, Krishna Madhavan, Susan Fosmire, Adam L. Green, Nicholas K. Foreman, Sujatha Venkataraman, Rajeev Vibhakar
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Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Haider M. Hassan, Majdina Isovic, Bart Kolendowski, Natasha Bauer-Maison, Oladapo Onabote, Matthew Cecchini, Aaron Haig, Saman Maleki Vareki, T. Michael Underhill, Joseph Torchia
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Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Kazunori Sasaki, Noriko Kojitani, Hiroko Hirose, Yohei Yoshihama, Hidefumi Suzuki, Miho Shimada, Ayumi Takayanagi, Akio Yamashita, Masa-aki Nakaya, Hisashi Hirano, Hidehisa Takahashi, Shigeo Ohno
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Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Donna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon-Yong An, Brooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, André M.M. Sousa, Andrew T.N. Tebbenkamp, Navjot Kaur, Forrest O. Gulden, Michael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, Lambertus...
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Precise Tuning of Cortical Contractility Regulates Cell Shape during Cytokinesis: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Nilay Taneja, Matthew R. Bersi, Sophie M. Baillargeon, Aidan M. Fenix, James A. Cooper, Ryoma Ohi, Vivian Gama, W. David Merryman, Dylan T. Burnette
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Insights into Gonadal Sex Differentiation Provided by Single-Cell Transcriptomics in the Chicken Embryo: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Martin Andres Estermann, Sarah Williams, Claire Elizabeth Hirst, Zahida Yesmin Roly, Olivier Serralbo, Deepak Adhikari, David Powell, Andrew Thomas Major, Craig Allen Smith
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PGC1α Controls Sucrose Taste Sensitization in <em>Drosophila</em>: Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Qiao-Ping Wang, Yong Qi Lin, Mei-Ling Lai, Zhiduan Su, Lisa J. Oyston, Teleri Clark, Scarlet J. Park, Thang M. Khuong, Man-Tat Lau, Victoria Shenton, Yan-Chuan Shi, David E. James, William W. Ja, Herbert Herzog, Stephen J. Simpson, G. Gregory Neely
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Myositis and myasthenia during nivolumab administration for advanced lung cancer: a case report and review of the literature: The immunotherapy significantly improved survival of non-small cell lung cancer patients, but it may cause immune-related adverse events, which are severe in less than 10% of cases. We report the case of one patient who developed myositis and myasthenia during nivolumab treatment for metastatic lung squamous carcinoma. Moreover, we reviewed literature data in order to identify...
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A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis: Derivatives of bis-aryl urea have been widely investigated for their various biological activities, such as antiviral, anti-inflammatory and antiproliferative. We evaluated a new chemical entity consisting of bis-aryl urea moiety, N69B, for its anticancer activities and explored their underlying molecular mechanism. The compound inhibited proliferation of multiple types of murine and human cancer cells...
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A case of pelvic giant cell tumor of bone, complete remission with denosumab: long duration of response: Although giant cell tumor of bone has been considered as a disease with benign course, it can lead to bone destruction and serious morbidity. A 19-year-old case was presented with hip pain. There was a recurrence after 9 months of curative surgical resection and zoledronic acid use, and as surgical morbidity would be high, antiosteoclastic receptor activator of nuclear factor kappa B ligand inhibitor...
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SUMOylation of vascular endothelial growth factor receptor 2 inhibits the proliferation, migration, and angiogenesis signaling pathway in non-small cell lung cancer: Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed in non-small cell lung cancer (NSCLC), and is the main target of antiangiogenesis therapy against this disease. However, there is limited evidence regarding its regulatory mechanism. Thus, elucidating the underlying mechanism of regulation of VEGFR2 is of great...
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Outcomes in hepatocellular carcinoma patients undergoing sorafenib treatment: toxicities, cellular oxidative stress, treatment adherence, and quality of life: The study of toxicities induced by sorafenib, as well as the identification of possible mechanisms and biomarkers of these toxicities, is important to improve the treatment and quality of life of hepatocellular carcinoma (HCC) patients. This study focused on toxicities, cellular oxidative stress, adherence, and quality of life of 11 patients...
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Antitumor activity of triptolide in SKOV3 cells and SKOV3/DDP in vivo and in vitro: This study was designed to investigate the antitumor activity of triptolide in ovarian cancer inoculated with SKOV3 and SKOV3/cisplatin (DDP) cells, and to assess the mechanisms. In-vivo and in-vitro experiments were designed to evaluate the effects of triptolide on the tumor growth of SKOV3 and SKOV3/DDP cells. The experiments were divided into four groups: a SKOV3 group, a SKOV3 + TP treatment group, a SKOV3/DDP...
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Tumor uptake and associated greater efficacy of anti-Her2 immunoliposome does not rely on Her2 expression status: study of a docetaxel-trastuzumab immunoliposome on Her2+ breast cancer model (SKBR3): Nanoparticles have been used for decades in breast cancer. More recently, anti-human epidermal receptor 2 (Her2) immunoliposomes are of rising interest. However, recent studies have questioned the actual relevance of using anti-Her2 antibodies to improve liposome distribution and efficacy. Using standard...
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Downregulation of lncRNA H19 sensitizes melanoma cells to cisplatin by regulating the miR-18b/IGF1 axis: Long noncoding RNAs (LncRNAs) lncRNA H19 has been shown to be involved in the chemotherapy resistance of cancer cells. However, the role of lncRNA H19 in chemotherapy resistance of melanoma cells remains unknown. Here, we determined lncRNA H19, miR-18b, and insulin-like growth factor 1 (IGF1) expression by utilizing quantitative real-time PCR. Cell proliferation ability and chemosensitivity were...
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Successful treatment with brentuximab vedotin for relapsed and refractory adult T cell leukemia: Although treatments for adult T-cell leukemia/lymphoma in the past two decades have advanced, the current standard treatment for aggressive adult T-cell leukemia/lymphoma, particularly in patients who are not eligible for stem cell transplantation, remains inadequate; therefore, treatments to prolong the duration of remission and provide relevant benefits in terms of survival and quality of life are needed....
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Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line: Different types of tumors often present an overexpression of cyclooxygenase-2. The aim of this study was to evaluate the effects of parecoxib (NSAID, cyclooxygenase-2 selective inhibitor) in the behavior of the human osteosarcoma MG-63 cell line, concerning several biological features. Cells were exposed to several concentrations of parecoxib for 48 hours. Cell viability/proliferation, cyclooxygenase-2 expression,...
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Cyclin-dependent kinase inhibitors plus aromatase inhibitor in first-line treatment hormone-receptor–positive/HER2-negative advanced breast cancer women with or without visceral disease: time to turn page?: Breast cancer is the most common female tumour type and accounts for the leading cancer mortality in women worldwide. Up to 75% of breast cancers express the oestrogen receptor or progesterone receptor (hormone-receptor–positive). Aromatase inhibitors were the preferred first-line treatment option....
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Predictors of outcome in elderly patients with metastatic colorectal cancer: the final results of a prospective phase II study of bevacizumab in combination with capecitabine as first-line treatment: In 2011, we demonstrated that bevacizumab in combination with capecitabine as first-line treatment is effective in elderly patients with metastatic colorectal cancer (mCRC). We present the final results of the study with data on tumor molecular biology, sidedness and postprogression therapy. Forty patients...
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Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells: Cardiac glycosides (CGs) are natural compounds traditionally used for the treatment of heart disorders, and recently new therapeutic possibilities were proposed. Their antitumor reports and clinical trials have notably enhanced, including those targeted for lung cancer, the most lethal type that lacks of new treatment agents, instigating the research of these molecules. The CGs studied here, named...
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Antitumor activity of a novel Aurora A/B kinases inhibitor TY-011 against gastric cancer by inducing DNA damage: TY-011, a novel Aurora A/B kinases inhibitor, was found in our previous study to exhibit prominent inhibitory effects on growth of gastric cancer, both in vitro and in vivo. To clarify the mechanisms of TY-011 in inhibiting proliferation of gastric cancer cells, the effects of TY-011 on mitosis, cell cycle, apoptosis and cellular DNA were checked in the present study. Our results showed...
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Albendazole suppresses cell proliferation and migration and induces apoptosis in human pancreatic cancer cells: This study aims to investigate the effects of albendazole on pancreatic cancer cells and to explore the possible mechanisms involved. MTT, colony formation, wound healing and Transwell assays and immunocytochemistry analyses of proliferation antigen Ki-67 were employed to evaluate the role of albendazole in pancreatic cancer cell line proliferation and migration. Moreover, flow cytometry...
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The Oncogenic Role of CENPA in Hepatocellular Carcinoma Development: Evidence from Bioinformatic Analysis: Objective. This study is aimed at investigating the predictive value of CENPA in hepatocellular carcinoma (HCC) development. Methods. Using integrated bioinformatic analysis, we evaluated the CENPA mRNA expression in tumor and adjacent tissues and correlated it with HCC survival and clinicopathological features. A Cox regression hazard model was also performed. Results. CENPA mRNA was significantly...
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The Predictors of High Dietary Salt Intake among Hypertensive Patients in Iran: Background. Hypertension and its complications are among the major health problems all over the world, particularly in developing countries. The aims of this study were to show that, weather the hypertensive patients follow the expertise recommendations and differences between men and women in their levels of knowledge and behavior in salt taking. Methods. The present cross-sectional study was conducted among all hypertensive...
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ctDNA Detection in Microfluidic Platform: A Promising Biomarker for Personalized Cancer Chemotherapy
ctDNA Detection in Microfluidic Platform: A Promising Biomarker for Personalized Cancer Chemotherapy: Early detection and characterization of circulating tumor DNA (ctDNA) can reveal mint of comprehensive biological insights from indicating the presence of tumor, identifying mutational changes of malignant cells, and allowing precision or targeted therapy together with monitoring disease progression, treatment resistance, and relapse of the disease. Apart from these, one of the greatest axiomatic...
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Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection: Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective...
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A Sensitive Fibre Optic Probe for Autofluorescence Spectroscopy of Oral Tongue Cancer: Monte Carlo Simulation Study: The objective of this paper is to determine the best optical probe configuration that would help to detect neoplastic lesions in oral tongue epithelial tissue. Three geometrical configurations are investigated. The first one is a single-fibre probe with different fibre diameters. The second one is a multitilted fibre probe that employs different tilting angles for emission and collection...
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To What Extent Can Orbital Cellulitis Emergency Aspect Influence the Diagnosis of Maxillary Sinus Lymphoma?: We present a case of a 46-year-old woman admitted to the emergency department for acute swelling and erythema of the right eyelid for 3 days. Ophthalmological examination was notable for 10/10, P2 best visual acuity, and inflammatory periorbital edema, without exophthalmia nor extraocular motility disturbance. Intraocular pressure was 14 mmHg and fundoscopic examination was not notable for...
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Survival of Patients with First and Metachronous Second Primary Breast Cancer or Lung Cancer Malignancy: Comparisons Using the SEER Database: AbstractIntroductionBreast cancer (BC) and lung cancer (LuC) are common malignancies. The survival of patients with metachronous second primary malignancy (MSPM) of BC and LuC after a first primary of BC and LuC remains unclear.MethodsData of patients with BC and LuC, with or without MSPM of BC and LuC, who were diagnosed from 2000 to 2014, were extracted from...
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Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs: Aim. To further investigate the mechanism behind the antitumor properties of berberine regarding lipid metabolism. Methods. Cell viability, proliferation, and apoptosis assays were performed to determine the antigrowth effects of berberine in vitro. Ectopic xenograft models in Balb/c nude mice were established to determine the antitumor effects of berberine in vivo. Results....
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The Role of Forced and Voluntary Training on Accumulation of Neural Cell Adhesion Molecule and Polysialic Acid in Muscle of Mice with Experimental Autoimmune Encephalomyelitis: It has been suggested that depletion of adhesion molecules is one of the factors associated with or possibly responsible for multiple sclerosis (MS) progression. The aim of this study was to investigate the effect of forced and voluntary training before and after induction of experimental autoimmune encephalomyelitis (EAE)...
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Orlistat-Induced Gut Microbiota Modification in Obese Mice: Introduction. Accumulating evidence has indicated that alterations of gut microbiota have been involved in various metabolic diseases. Orlistat, a reversible inhibitor of pancreatic and gastric lipase, has beneficial effects on weight loss and metabolism. However, the effect of orlistat on the composition of gut microbiota remains unclear. Objective. We aimed to explore the effect of orlistat on gut microbiota in high-fat diet (HFD) fed...
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Soybean isoflavone can protect against osteoarthritis in ovariectomized rats: AbstractOsteoarthritis (OA) is a chronic and incurable disease and a leading cause of significant pain and disability that is closely associated with aging and obesity. An appropriate long-term therapy regimen is presently unknown. An estrogen deficiency after menopause increases the incidence and severity of OA in women. Soybean isoflavone have weak estrogenic effects in several organs and have been considered as a potentially...
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Facial nerve electrodiagnostics for patients with facial palsy: a clinical practice guideline: AbstractPurposeFacial nerve electrodiagnostics is a well-established and important tool for decision making in patients with facial nerve diseases. Nevertheless, many otorhinolaryngologist—head and neck surgeons do not routinely use facial nerve electrodiagnostics. This may be due to a current lack of agreement on methodology, interpretation, validity, and clinical application. Electrophysiological analyses...
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Pharmacogenomics of breast cancer: highlighting CYP2D6 and tamoxifen: AbstractPurposeTo review recent pharmacogenomics studies on breast cancer patients undergoing tamoxifen therapy, highlighting how our knowledge on cytochrome P450 2D6 (CYP2D6) can help to guide the development of adjuvant therapies for these patients.MethodsA comprehensive literature search was conducted. Articles reporting findings pertaining to the effect of CYP2D6 on the therapeutic efficacy of tamoxifen, those reporting how...
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Three-Year Follow-Up with the Bone Conduction Implant: Background: The bone conduction implant (BCI) is an active transcutaneous bone conduction device where the transducer has direct contact to the bone, and the skin is intact. Sixteen patients have been implanted with the BCI with a planned follow-up of 5 years. This study reports on hearing, quality of life, and objective measures up to 36 months of follow-up in 10 patients. Method: Repeated measures were performed at fitting and after 1, 3, 6,...
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Optimization of timing of hepatocellular phase imaging after gadoxetate disodium injection for evaluation of patients with neuroendocrine tumor: AbstractPurposeMetastatic gastroenteropancreatic neuroendocrine neoplasms (mGEP-NEN) are indolent malignancies which undergo frequent imaging follow-up. Hepatocellular phase (HCP) MR with hepatocellular-specific contrast agent is widely used to evaluate mGEP-NEN liver metastases but is commonly performed after a 20-min delay which prolongs scan time. The...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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