1a8x98-i64bd.html[Biomolecules] Newsletter, January 2020.eml 2a993x-n5sq2.html[IJERPH] Quarterly Newsletter, January 2020.eml 3aiem7-lz4t2.html[Vaccines] Quarterly Newsletter, January 2020.eml 4aij6p-mhzim.html20 Most Talked About MMWR Reports of 2019.eml 5a8mzv-ghkyx.htmlAccepted Articles Alert_ Journal of the European Academy of Dermatology and Venereology.eml 6a3fdn-7tbf9.htmlAggression and Violent Behavior _ Volume 50.eml 7aud2i-yp24c.htmlAmerican Journal of Otolaryngology_ Alert 07 January.eml 8adrt3-1wm64.htmlAnatomical...
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Journal of Clinical MedicineJCM, Vol. 9, Pages 177: Iodine Status, Thyroid Function, and Birthweight: A Complex Relationship in High-Risk PregnanciesJCM, Vol. 9, Pages 177: Iodine Status, Thyroid Function, and Birthweight: A Complex Relationship in High-Risk Pregnancies Journal of Clinical Medicine doi: 10.3390/jcm9010177 Authors: Velasco Sánchez-Gila Manzanares Taylor García-Fuentes (1) Background: The consequences of iodine deficiency and/or thyroid dysfunction during pregnancy have been extensively...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 433: Factors Associated with Adolescents' Internet Use Duration by Suicidal IdeationIJERPH, Vol. 17, Pages 433: Factors Associated with Adolescents' Internet Use Duration by Suicidal Ideation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020433 Authors: Myoungjin Kwon Sun Ae Kim Wi-Young So Purpose: This study aimed to identify the factors associated with Internet use...
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CellsCells, Vol. 9, Pages 158: Increased O-GlcNAcylation of c-Myc Promotes Pre-B Cell ProliferationCells, Vol. 9, Pages 158: Increased O-GlcNAcylation of c-Myc Promotes Pre-B Cell Proliferation Cells doi: 10.3390/cells9010158 Authors: Lee Kwon Lee Lee Kim Kim Park O-linked β-N-acetylglucosamine (O-GlcNAc) modification regulates the activity of hundreds of nucleocytoplasmic proteins involved in a wide variety of cellular processes, such as gene expression, signaling, and cell growth; however, the...
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AntibodiesAntibodies, Vol. 9, Pages 2: Antibody Conjugates-Recent Advances and Future InnovationsAntibodies, Vol. 9, Pages 2: Antibody Conjugates-Recent Advances and Future Innovations Antibodies doi: 10.3390/antib9010002 Authors: Donmienne Leung Jacqueline M. Wurst Tao Liu Ruben M. Martinez Amita Datta-Mannan Yiqing Feng Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting...
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Prognostic Value of Combined Detection of Serum IL6, YKL-40, and C-reactive Protein in Patients with Unresectable Pancreatic Cancer: Background:IL6 and YKL-40 (also known as chitinase 3-like 1 protein, CHI3L1) are produced by pancreatic cancer cells and macrophages and activate inflammation. C-reactive protein (CRP) is synthesized mainly in hepatic cells and primarily stimulated by IL6. The aim of this study was to determine the prognostic value of combined detection of serum IL6, YKL-40, and CRP...
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Commercial Gene Expression Tests for Prostate Cancer Prognosis Provide Paradoxical Estimates of Race-Specific Risk: Background:Commercial gene expression signatures of prostate cancer prognosis were developed and validated in cohorts of predominantly European American men (EAM). Limited research exists on the value of such signatures in African American men (AAM), who have poor prostate cancer outcomes. We explored differences in gene expression between EAM and AAM for three commercially available...
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The incidence of fatal foetal anomalies associated with perinatal mortality in Ireland: AbstractObjectiveThe term fatal foetal anomaly (FFA) describes a condition likely to lead to death of the foetus in utero or within 28 days of birth. This study aimed to identify what congenital anomalies are responsible for perinatal death and whether they are classified as a FFA in accordance with criteria outlined in Irish legislation.MethodsAnonymised data pertaining to perinatal deaths from 2011 to 2016 in...
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Prediction of outcome in fetal autoimmune complete heart block: AbstractAssessing cardiac function and risk stratification in fetal anti‐SSA/SSB complete atrioventricular block (CAVB) is challenging. We aimed to evaluate the cardiovascular profile score (CVP) and its components in surveillance of fetuses with autoimmune CAVB.MethodsRetrospective cohort review of CAVB pregnancies, excluding fetuses with significant cardiac anomalies.ResultsCAVB in 17 fetuses, diagnosed at mean gestational age of 23±5weeks....
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Does prenatal counseling for pregnancies complicated by multiple fetal abnormalities concord with postnatal outcomes?: AbstractObjectiveIn pregnancies complicated by multiple fetal abnormalities, our objective was to determine the degree of concordance between prenatal prognosis and postnatal outcomes.MethodRetrospective cohort study of pregnancies with multiple fetal abnormalities referred to the Fetal Concerns Center of Wisconsin (FCCW) from 2015‐2018. We reviewed records for anomalies, given prognostic...
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An interesting case of aorto-left ventricular tunnel: Musthafa Janeel, Swaminathan Vaidyanathan, Annie Arvind, Neville A G SolomonAnnals of Pediatric Cardiology 2020 13(1):108-110
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Complete sternal cleft with tetralogy of Fallot: Debasis Das, Nilanjan Dutta, Pratik Pandey, Adhish Basu, Manish Kumar Sharma, Rangan Koley, Amitabha ChattopadhyayAnnals of Pediatric Cardiology 2020 13(1):81-83Complete sternal cleft is a very rare congenital midline defect of the sternum. It is not uncommonly associated with intracardiac defects. We report a case of a 2-year-old child with complete sternal cleft and tetralogy of Fallot who presented with cyanotic spells. The child underwent total...
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Anatomically corrected malposition of great arteries: A nidus for the left ventricular outflow tract obstruction: Palak Gupta, Kalyanraddi N Chikkagoudar, Nageswara Rao KonetiAnnals of Pediatric Cardiology 2020 13(1):105-106
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Superior vena caval thrombosis after a neonatal arterial switch procedure: Hayley M Wilcox, Neil S Devejian, Javier Sanchez, Walter Edge, Karen Larsen, Shashikanth AmbatiAnnals of Pediatric Cardiology 2020 13(1):78-80Superior vena cava (SVC) and inferior vena cava obstructions were once well-documented complications from the Mustard repair for D-transposition of the great arteries (TGA), occurring in 10%–40% patients; however, they are rarely documented with the current, more common arterial switch...
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Unusual association of transposition of great arteries with infradiaphragmatic pulmonary venous return: Giuseppe Scrascia, Anna Maria Pia Grimaldi, Dario Troise, Gabriele ScalzoAnnals of Pediatric Cardiology 2020 13(1):75-77A 21-day-old baby with transposition of the great arteries with intact ventricular septum, infradiaphragmatic totally anomalous pulmonary venous connection, and atrial septum defect underwent combined arterial switch operation, totally anomalous venous connection repair, and atrial...
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Virtual dissection: An alternative to surface-rendered virtual three-dimensional cardiac model: Saurabh Kumar Gupta, Robert H AndersonAnnals of Pediatric Cardiology 2020 13(1):102-103
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Mystery still unresolved: Untouched "Blue heart" presenting at 40yrs of age: Sanjeev H Naganur, Ashish Tiwari, CR PruthviAnnals of Pediatric Cardiology 2020 13(1):72-74The modern-day surgical techniques and strategies have changed the outlook of patients with dextro-transposition of great arteries (d-TGA). The survival of an unrepaired d-TGA into late adulthood is difficult to explain. Even when large intracardiac shunts are present, it still remains a lethal cyanotic congenital heart disease if...
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Circumflex retroesophageal left aortic arch with right ductus arteriosus: A rare complete vascular ring diagnosed on computed tomography angiography: Niraj Nirmal Pandey, Manish Shaw, Sakshi Sachdeva, Gurpreet Singh Gulati, Shyam S KothariAnnals of Pediatric Cardiology 2020 13(1):98-99A circumflex retroesophageal left aortic arch with a right-sided ductus is an extremely rare cause of a complete vascular ring, which may result in severe tracheobronchial compression, leading to respiratory compromise,...
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Balloon angioplasty of aortic coarctation in critically ill newborns using axillary artery access: Giovanni Meliota, Maristella Lombardi, Pierluigi Zaza, Maria Rosaria Tagliente, Ugo VairoAnnals of Pediatric Cardiology 2020 13(1):67-71Balloon angioplasty may be performed as the first treatment of aortic coarctation to stabilize newborns too sick for immediate surgery. The issue of vascular access is the key to the successful treatment of critical newborns. In our study, we argue that the lesser-known...
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Isolated persistence of the fifth aortic arch in an infant presenting with congestive heart failure: Giovanni Meliota, Maristella Lombardi, Pierluigi Zaza, Maria Rosaria Tagliente, Paolo Versacci, Gabriele Scalzo, Ugo VairoAnnals of Pediatric Cardiology 2020 13(1):91-94The persistence of the fifth aortic arch (PFAA) in postnatal life is an extremely rare and controversial cardiovascular malformation. PFAA is defined as an extra-pericardial vessel arising from the ascending aorta proximal to the origin...
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The science and art of aortic and/or pulmonary root translocation: Supreet P Marathe, Sachin TalwarAnnals of Pediatric Cardiology 2020 13(1):56-66This review aims to present and compare different surgical techniques of root translocation of the great arteries except the Ross procedure. The historical aspects, technical considerations, and results are briefly elucidated.
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Caught-off guard: Unguarded mitral valve orifice in usual atrial arrangement with discordant atrioventricular connections and pulmonary atresia: Nayan Banerji, Mani Ram Krishna, Raman Krishna Kumar, Robert H AndersonAnnals of Pediatric Cardiology 2020 13(1):84-86Unguarding of an atrioventricular valvar orifice is a rare form of congenital heart disease that requires staged functionally univentricular palliation. Unguarding of the mitral valvar orifice has previously been reported in the setting of...
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Lung injury caused by exposure to the gaseous fraction of exhaust from biomass combustion (cashew nut shells): a mice model: AbstractCurrently, to reduce the use of nonrenewable energy sources in energy matrices, some industries have already incorporated biomass as a source of energy for their processes. Additionally, filters are used in an attempt to retain the particulate matter present in exhaust gases. In this work, the emission gases of a cashew nut shell (CNS) combustion reactor and the deleterious...
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The novel indicators of moderate to severe sleep apnea: fibrinogen to albumin ratio vs. CRP to albumin ratio: AbstractPurposeThis study aimed at investigating the association of severity of obstructive sleep apnea with the markers of inflammation as fibrinogen to albumin ratio and C-reactive protein to albumin ratio.MethodsWe included 126 patients admitted to sleep disorders outpatient clinic. We constituted four groups by reference to the apnea–hypopnea index (mild-moderate-severe sleep apnea and...
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Congenital left atrial appendage pseudoaneurysm, cardiomyopathy, and mitral regurgitation: Yaron D Barac, Quintin Quinones, Jacob Schroder, Donald D GlowerAnnals of Pediatric Cardiology 2020 13(1):107-108
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Genetic abnormalities/syndromes significantly impact perioperative outcomes of conotruncal heart defects: Subhrajit Lahiri, Wernovsky Gil, Salyakina Daria, Gruber Joshua, Jayakar Parul, Burke Redmond, Welch ElizabethAnnals of Pediatric Cardiology 2020 13(1):38-45Objectives : The main objective of the study is to characterize the effects of genetic abnormalities/syndromes (GA/S) on perioperative outcomes of cardiac surgeries involving repair of conotruncal heart defects (CTHD). Design : The study...
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An evolving anesthetic protocol fosters fast tracking in pediatric cardiac surgery: A comparison of two anesthetic techniques: Vipul K Sharma, Gaurav Kumar, Saajan Joshi, Nikhil Tiwari, Vivek Kumar, H Ravi RamamurthyAnnals of Pediatric Cardiology 2020 13(1):31-37Background: The past two decades have seen rapid development of new surgical techniques for repair as well as palliation of complex congenital heart diseases. For a better patient outcome, minimal postoperative ventilation remains one of...
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An arcade in the heart: Multimodality imaging: N M Sharath Babu, Leena Robinson Vimala, Lijo Varghese, Oommen K GeorgeAnnals of Pediatric Cardiology 2020 13(1):95-97Congenital mitral stenosis (MS) is a spectrum of anomalies that result in functional and anatomic obstruction of inflow into the left ventricle. Mitral arcade is one of the varieties of congenital MS where there is an abnormal development of chordae tendineae, resulting in stenosis, regurgitation, or both. Here, we describe the case of...
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Normal reference ranges for the left ventricular mass and left ventricular mass index in preterm infants: Lulu Abushaban, Jebaraj Rathinasamy, Prem N Sharma, Mariappa Thinakar VelAnnals of Pediatric Cardiology 2020 13(1):25-30Objective :The objective of this study is to establish normal reference ranges for the left ventricular mass (LVM) and LVM index (LVMI) in preterm infants according to the body surface area (BSA) and assess their correlation with body weight and gestational age. Subjects and...
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Diagnostics, Vol. 10, Pages 31: Duodenal Ulceration in a Child with Coeliac Disease: Diagnostics, Vol. 10, Pages 31: Duodenal Ulceration in a Child with Coeliac DiseaseDiagnostics doi: 10.3390/diagnostics10010031Authors: Polina S. Lototskaya Marina A. Manina Aleksandr S. Tertychnyy Andrey A. Zamyatnin Svetlana I. Erdes Coeliac disease (CD) is a gluten-dependent inflammatory disease of the small bowel that affects up to 1% of the global population. Herein, the presence of ulcers, erosions,...
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Premorbid functional reserve modulates the effect of rehabilitation in multiple sclerosis: AbstractBackgroundPremorbid physically and intellectually enriching lifestyles have increasingly been recognized as able to mitigate the risk of disease-related disability in patients with multiple sclerosis (MS).ObjectiveTo explore if premorbid physical activity, cognitive reserve and trait personality act as proxies for functional reserve that contributes to rehabilitation outcome.MethodsWe recruited all...
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Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification: Thyroid gland teratomas are rare tumors that span a wide clinicopathologic spectrum. Although benign and immature teratomas arise in infants and young children and generally have good outcomes, malignant teratomas affect adults and follow an aggressive course. This divergent behavior raises the possibility that benign/immature and malignant teratomas are...
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Uterine Cervical Sarcoma With a Novel RET-SPECC1L Fusion in an Adult: A Case Which Expands the Homology Between: RET: -rearranged and: NTRK: -rearranged Tumors:
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Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study: Polymorphous adenocarcinoma (PAC) shows histologic diversity with streaming and targetoid features whereas cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominantly cribriform and solid patterns with glomeruloid structures and optically clear nuclei. Opinions diverge on whether CASG represents a separate...
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Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice: AbstractObjectivesTo investigate the antihyperuricemia and nephroprotective effects of Orthosiphon stamineus extracts on hyperuricemia (HUA) mice and explore the potential mechanisms.MethodsOrthosiphon stamineus extracts were extracted using 50% ethanol and enriched using ethyl acetate, and characterised utilising UPLC/ESI‐MS. A potassium oxonate (PO) induced hyperuricemic mouse model was...
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Solar radiation attenuation by aerosol: application to solar farms: AbstractThe use of solar energy requires precise insolation knowledge of the considered site. Solar irradiance depends on geographical and astronomical parameters and variable characteristics of the atmosphere such as aerosol or cloud charge, which has a very important attenuation and pollution role. This study presents the estimate of the annual insolation of sites close to several solar farms. Insolation is calculated from Iqbal's...
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Renal Function–Adjusted D-Dimer Levels in Critically Ill Patients With Suspected Thromboembolism: AbstractObjectives:Diagnosing thromboembolic disease typically includes D-dimer testing and use of clinical scores in patients with low to intermediate pretest probability. However, renal dysfunction is often observed in patients with thromboembolic disease and was previously shown to be associated with increased D-dimer levels. We seek to validate previously suggested estimated glomerular filtration...
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Cancers, Vol. 12, Pages 159: Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pylori: Cancers, Vol. 12, Pages 159: Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pyloriCancers doi: 10.3390/cancers12010159Authors: Irshad Sharafutdinov Steffen Backert Nicole Tegtmeyer Cortactin is an actin binding protein and actin nucleation promoting factor regulating cytoskeletal rearrangements in nearly all eukaryotic cell types. From this perspective, cortactin...
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Cancers, Vol. 12, Pages 160: Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate Cancer: Cancers, Vol. 12, Pages 160: Circulating Tumor Cells as a Marker of Disseminated Disease in Patients with Newly Diagnosed High-Risk Prostate CancerCancers doi: 10.3390/cancers12010160Authors: Wojciech A. Cieślikowski Joanna Budna-Tukan Monika Świerczewska Agnieszka Ida Michał Hrab Agnieszka Jankowiak Martine Mazel Michał Nowicki Piotr...
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Effect of Anesthesia on Microelectrode Recordings During Deep Brain Stimulation Surgery: A Narrative Review: Deep brain stimulation (DBS) is an effective surgical treatment for patients with various neurological and psychiatric disorders. Clinical improvements rely on careful patient selection and accurate electrode placement. A common method for target localization is intraoperative microelectrode recording (MER). To facilitate MER, DBS surgery is traditionally performed under local or regional...
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Use of percutaneous carotid artery access for performing pediatric cardiac interventions: Single-center study: Tugcin Bora PolatAnnals of Pediatric Cardiology 2020 13(1):16-24Background : Carotid artery (CA) access allows a more straight route for many left heart lesions. This has previously been achieved via a surgical cut-down approach in certain pediatric cardiac interventions. However, there are little data considering CA access in pediatric cases, percutaneously. Aim : We hypothesized that there...
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Double drainage of total anomalous pulmonary venous connection: A rare variant of mixed total anomalous pulmonary venous connection: Mani Ram Krishna, Ganesh Kumar Gnanappa, Jonathan Mervis, Jonathan Forsey, Julian Ganesh Ayer, Yishay OrrAnnals of Pediatric Cardiology 2020 13(1):100-101Total Anomalous Pulmonary Venous Connection (TAPVC) is frequently classified based on the system proposed by Craig, Darling and Rothney. Occasionally variants are reported which do not fit into these classic forms....
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Balloon pulmonary valvuloplasty in neonates with critical pulmonary stenosis: Jugular or femoral: Erick Hoetama, Radityo Prakoso, Poppy Surwianti Roebiono, Indriwanto Sakidjan, Yovi Kurniawati, Sisca Natalia Siagian, Olfi Lelya, Anna Ulfah Rahajoe, Ganesja Moelia Harimurti, Oktavia LilyasariAnnals of Pediatric Cardiology 2020 13(1):11-15Background: Critical pulmonary stenosis (PS) is one of the life-threatening congenital heart diseases which present during the neonatal period with cyanosis. Surgical...
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Transcatheter closure of atrial septal defect in symptomatic children weighing ≤10 kg: Addressing unanswered issues from a decade of experience: Bharti Sharma, Robin Pinto, Bharat DalviAnnals of Pediatric Cardiology 2020 13(1):4-10Background and Objectives: Device closure of secundum atrial septal defect is shown to be feasible and effective in children weighing ≤10 kg. Issues such as how large is too large, how to choose device size, does the length of the interatrial septum (IAS) matter, and need...
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Umbilical artery catheter, aortic dissection, carotid cannulation, and pseudoaneurysm in a neonate: A tale of propagating pathology: Justin Wang, Thomas Semple, Carles Bautista-Rodriguez, Andreas Hoschtitzky, Nick Cheshire, Amy Chan-DominyAnnals of Pediatric Cardiology 2020 13(1):87-90Arterial dissections are uncommon in neonates. Complications include thrombosis, bleeding, dissection, aneurysm and pseudoaneurysm. We report an unusual case of multisite pathology (dissection and pseudoaneurysm) following...
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Reversal of Vasodilatory Shock: Current Perspectives on Conventional, Rescue, and Emerging Vasoactive Agents for the Treatment of Shock: Understanding the different mechanisms of vasoconstrictors is crucial to their optimal application to clinically diverse shock states. We present a comprehensive review of conventional, rescue, and novel vasoactive agents including their pharmacology and evidence supporting their use in vasodilatory shock. The role of each drug in relation to the Surviving Sepsis...
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Outcomes of HIV treatment from the private sector in low-income and middle-income countries: a systematic review protocol: IntroductionPrivate sector provision of HIV treatment is increasing in low-income and middle-income countries (LMIC). However, there is limited documentation of its outcomes. This protocol reports a proposed systematic review that will synthesise clinical outcomes of private sector HIV treatment in LMIC.Methods and analysisThis review will be conducted in accordance with the...
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Sexual health needs of female sex workers in Cote dIvoire: a mixed-methods study to prepare the future implementation of pre-exposure prophylaxis (PrEP) for HIV prevention: ObjectiveTo describe sexual and reproductive health (SRH) needs of female sex workers (FSWs) to inform the future implementation of pre-exposure prophylaxis (PrEP) for HIV prevention in this population.Design and settingThe ANRS 12361 PrEP-CI cross-sectional and mixed-methods study was designed and implemented with two community-based...
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Study protocol for a phase II, multicentre, prospective, non-randomised clinical trial to assess the safety and efficacy of infusing allogeneic activated and expanded natural killer cells as consolidation therapy for paediatric acute myeloblastic leukaemia: IntroductionAcute myeloblastic leukaemia (AML) constitutes the second most common haematological malignancy in the paediatric population. Current treatment regimens are based on the administration of polychemotherapy, combining high doses of cytarabine...
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Risk of venous thromboembolism in patients undergoing gastric cancer surgery: protocol for a systematic review and meta-analysis: IntroductionVenous thromboembolism (VTE) is a serious life-threatening complication in patients with gastric cancer. Abnormal coagulation function and tumour-related treatment may contribute to the occurrence of VTE. Many guidelines considered that surgical treatment would put patients with cancer at high risk of VTE, so positive prevention is needed. However, there are...
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A Comorbidity Model of Myocardial Ischemia/Reperfusion Injury and Hypercholesterolemia in Rat Cardiac Myocyte Cultures: IntroductionThe use of comorbidity models is crucial in cardioprotective drug development. Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as aggravates ischemia/reperfusion (I/R)-induced myocardial injury. Endogenous cardioprotective mechanisms against I/R are impaired in hyperlipidemic and hyperglycemic in vivo animal models. Therefore, our aim was...
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Inflammatory Effects of High and Moderate Intensity Exercise—A Systematic Review: Background: Exercise leads to a robust inflammatory response mainly characterized by the mobilization of leukocytes and an increase in circulating inflammatory mediators produced by immune cells and directly from the active muscle tissue. Both positive and negative effects on immune function and susceptibility to minor illness have been observed following different training protocols. While engaging in moderate activity...
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Lower Nr5a2 Level Downregulates the β-Catenin and TCF-4 Expression in Caerulein-Induced Pancreatic Inflammation: Nuclear receptor subfamily 5 group A member 2 (Nr5a2) is widely involved in the physiological and pathological processes of the pancreas. However, the cytological and molecular evidence regarding how Nr5a2 implicated in acute pancreatitis (AP) remains insufficient. Here, we explored this problem by using cellular AP model in both normal and Nr5a2 silenced AR42J pancreatic acinar cells....
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Potential of Lipoprotein(a)-Lowering Strategies in Treating Coronary Artery Disease: AbstractHigh levels of lipoprotein(a) [Lp(a)] are considered causal risk factor of cardiovascular disease (CVD), including aortic stenosis. The 2019 ESC/EAC guidelines for the management of dyslipidaemias recommend to measure Lp(a) at least once in each adult person's lifetime to identify those with inherited Lp(a) levels > 180 mg/dL (> 430 nmol/L) who may have a cardiovascular risk similar to heterozygous...
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Ileal Transposition Increases Pancreatic β Cell Mass and Decreases β Cell Senescence in Diet-Induced Obese Rats: AbstractBackgroundIleal transposition (IT) is a surgical procedure to investigate the role of the distal small intestine in metabolic improvements induced by bariatric/metabolic surgery, which has been applied to some human cases. We performed IT in diet-induced obese rats to investigate the effect of IT on glucose metabolism and β cell senescence.MethodsSprague-Dawley rats were fed high-fat...
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Total Oesophagogastric Dissociation in Neurologically Impaired Children: 18 Years' Experience and Long-Term Follow-Up: Objectives: Total Oesophago-gastric Dissociation (TOGD) is an alternative antireflux surgery for neurologically impaired children because of a 16%-38% fundoplication failure rate. This study evaluates TOGD's feasibility and its long-term efficacy both as a Primary and as a 'Rescue' procedure after failed fundoplication.Methods: 30 patients (18 male) who underwent TOGD between 2000...
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Extensive subpial cortical demyelination is specific to multiple sclerosis: AbstractCortical demyelinated lesions are frequent and widespread in chronic multiple sclerosis (MS) patients, and may contribute to disease progression. Inflammation and related oxidative stress have been proposed as central mediators of cortical damage, yet meningeal and cortical inflammation is not specific to MS, but also occurs in other diseases. The first aim of this study was to test whether cortical demyelination...
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Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence: Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real-world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000–2012 and their matched controls. At a median of 12 years, VLBW prematurity...
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Development of a Prognostic Score to Predict Mortality in Patients with Pediatric Acute Liver Failure: Objectives: This study aims to develop a new prognostic score based on changes in serial laboratory data from patients with pediatric acute liver failure (PALF).Methods: We retrospectively reviewed data on 146 patients with PALF at the Seoul National University Children Hospital (SNUCH) and the Asan Medical Center (AMC). Daily morning laboratory records were obtained for up to 7 days after diagnosis...
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Functional tricuspid regurgitation: indications, techniques, and outcomes: AbstractFunctional tricuspid regurgitation (TR) results from asymmetric dilation of the tricuspid valve annulus. This often occurs due to right ventricular enlargement and dysfunction as a consequence of myocardial or valvular abnormalities of the left heart. Even mild TR at the time of left-sided valvular surgery may worsen postoperatively, which carries poor prognostic implications. In spite of data revealing poor outcomes...
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Informing Medication Discontinuation Decisions among Older Adults with Relapsing-Onset Multiple Sclerosis: AbstractBackgroundFor older adults with relapsing-onset multiple sclerosis (MS), limited information is available to inform if, or when, disease-modifying drugs (DMDs) may be safely discontinued.ObjectiveThe aim of this study was to project the outcomes of DMD discontinuation among older adults with relapsing-onset MS.MethodsWe projected the 10-year outcomes of discontinuation of a DMD (interferon-β,...
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Swyer-James-MacLeod syndrome and pulmonary arteriovenous malformations: a rare combination: This case describes a female patient who presented with an acute on chronic deterioration in respiratory symptoms, on a background of chronic obstructive pulmonary disease and heavy cigarette smoking. Chest radiograph demonstrated long-standing hyperlucency of the right lower lobe, with further imaging later confirming the rare combination of Swyer-James-MacLeod syndrome and multiple pulmonary arteriovenous...
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Multiple myeloma with extensive AL amyloidosis presenting as chronic diarrhoea: We present a 52-year-old man admitted to the hospital with diarrhoea and lower extremity weakness ongoing for the past 3 months. The patient was found to have malabsorptive diarrhoea, hypoproliferative anaemia and renal insufficiency with proteinuria. Extensive workup was performed including a bone marrow biopsy with 20% plasma cells, renal and duodenal biopsies with Congo-red staining revealed amyloid deposition. The...
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Infectious conjunctivitis caused by Pseudomonasaeruginosa in infected and extrused scleral buckles: Extrusion of the scleral buckle is one of the complications patients may encounter undergoing the surgical treatment for retinal detachment. We present two cases of persistent Pseudomonasaeruginosa-related conjunctivitis which infected the silicone explant after retinal surgery. One of them is a 73-year-old Caucasian female patient with hyperaemia, intense pain and mucopurulent discharge. After the...
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Novel mutagenesis and screening technologies for food microorganisms: advances and prospects: AbstractMicroorganisms are indispensable in the food industry, but wild-type strains hardly meet the current industrial demands due to several undesirable traits. Therefore, microbial strain improvement offers a critical solution to enhance the food industry. Traditional techniques for food microbial improvement, such as the use of chemical mutagens and manual isolation/purification, are inefficient, time-consuming,...
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Impact of 'Chief-Pharmacist System' on drug expenditures and rational drug use: AbstractBackground Over the last few years, pharmacists in China have been searching for effective strategies to expand their roles in pharmaceutical care. In September 2012, the Beijing Chaoyang Hospital was the first in China to establish the Chief-Pharmacist System aimed to let pharmacists be a responsible part of the multi-disciplinary care team. Objective To describe the Chief-Pharmacist System and explore its impact...
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Journal of Clinical and Diagnostic Research : JCDRJCDR Research & Publications Private LimitedMultiple Mandibular Exostoses: A Rare Case ReportMansi Bansal, Sanjay Rastogi, and Anamika SharmaAdditional article informationAbstractMultiple maxillary and mandibular exostoses are common localized overgrowths of the bone. They are non-neoplastic and are thought to be reactive or developmental in origin. These exostoses need to be accurately distinguished from the other more diagnostically significant...
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Rib Exostoses Presenting as Mediastinal Masses: A Rare Presentation: Costal osteocartilaginous exostoses, also known as osteochondromas, are the most common neoplasms of the long bones but are rare tumors of the ribs. Osteochondroma is often asymptomatic and incidentally observed. Tumors typically begin to grow before puberty and continue until bone maturation is reached. Our paper presents the case of a 16-year-old young male who was admitted to the hospital with nonspecific symptoms and having...
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A rare case of non-clostridial infection in a non-diabetic patient: A 76-year-old man presented with neck swelling associated with pain and fever. On examination, there was a submental neck swelling. His initial CT scan showed multiloculated abscess centred in the left submandibular gland. He remained febrile despite on intravenous ceftriaxone and metronidazole. A repeat CT scan revealed significant worsening with multiple pockets of fluids with gas locules in the deep neck spaces. He subsequently...
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Acute Epstein-Barr infection presenting as cholecystitis with ascites: A young female patient presented with features of ascites and cholecystitis. She was subsequently diagnosed with an acute Epstein-Barr virus infection. This is a rare presentation of a common infection. The patient was managed conservatively and the illness resolved within 6 weeks.
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An unusual case of extreme thrombocytosis caused by iron deficiency: Iron deficiency is a common cause of reactive thrombocytosis resulting in usually mild to moderately increased but sometimes even in extreme thrombocytosis (ie, >1000x109/L). We report a case of a 34-year-old woman who developed an increased platelet count of 1953x109/L. Upon admission, cytoreductive therapy was initiated until an underlying chronic myeloproliferative neoplasia was ruled out. The patient had undergone bariatric...
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Paediatric porphyria and human hemin: a treatment challenge in a lower middle income country: Here, we report a case of a 15-year-old girl who presented to the emergency department with symptoms of abdominal pain, nausea, vomiting and seizures. She was diagnosed with acute intermittent porphyria. Treatment was started by removing all porphogenic drugs, providing high glucose intake (oral and intravenous), which initially resulted in good clinical outcomes. However, she deteriorated again and also...
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Glue pulmonary embolism and pulmonary oedema as a rare complication after endovascular embolisation of oesophageal varices:
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Coughing up clues: 16-year-old girl with acute haemoptysis: A 16-year-old previously well girl presented with bilateral painful lower leg swelling and non-pruritic blanching rash across her torso and upper and lower limbs. These symptoms started after commencing amoxicillin for presumed tonsillitis. She was diagnosed with serum sickness-like illness and started on non-steroidal agents. The rash and painful leg swelling improved over the next 48 hours. However, she subsequently developed fevers, cough...
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Takayasu arteritis in a rural hospital in Indonesia: Takayasu arteritis (TA) is a rare chronic granulomatous inflammation of the aorta or its branches and is prevalent all around the world. It causes stenosis of large arteries and ischaemic damage to target organs. There is usually a delay in recognising TA because of the rarity and unfamiliarity with the disease, unspecific early symptoms and lack of diagnostic equipment for early diagnosis. In this report, we present a case of an 18-year-old woman...
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Atypical dysphagia with end-stage oesophageal disease 30 years post Angelchik device placement in a 72-year-old man: Here we describe an atypical presentation of progressive dysphagia in a 72-year-old man leading to frequent regurgitations over the course of 30 years. Investigations revealed a foreign body ring surrounding the proximal stomach and dilation of the oesophagus proximal to the gastro-oesophageal junction. An Angelchik device was extracted; however, the patient's rapid deterioration prior...
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Intravenous epinephrine overdose in prehospital management of suspected anaphylaxis: A 65-year-old woman called paramedics for stridor and neck swelling following an insect bite with a possible anaphylactic reaction. On arrival paramedics administered intramuscular epinephrine without any observed improvement in stridor. Paramedics then prepared 5 mg of 1:1000 epinephrine for nebulised administration, which was inadvertently given intravenously. The patient developed tachycardia, anxiety and a severe...
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Calcified stone in intestinal blind loop after 60 years of surgical treatment of complex jejunal atresia: an attempt to understand an enigma: A 60-year-old woman was presented in emergency department with abdominal pain and vomiting for 1 day. She was known to have seropositive rheumatoid arthritis. Importantly, she was treated surgically for complex jejunal atresia and duplication surgery, when she was 6 days old. CT scan showed intestinal obstruction secondary to intussception. Patient had lapartomy...
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Incidental urothelial rest within the vermiform appendix of a paediatric male patient: an extremely rare entity:
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Anaphylaxis to goat/sheeps milk in a 4-year-old boy tolerant to cows milk: Immune-mediated reactions to dairy products may vary depending on the mammalian source. We present a case of anaphylaxis to goat/sheep's milk with tolerance to cow's milk. A 4-year-old boy of Eastern European descent presented with gastrointestinal and respiratory symptoms within minutes after eating a goat/sheep's milk-derived food product. The tryptase level measured 1 hour post initial symptoms and 1 month after the allergic...
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Tumour-like presentation of atypical posterior reversible encephalopathy syndrome with prominent brainstem involvement: Typical posterior reversible encephalopathy syndrome (PRES) is a clinical-neuroradiological entity characterised by bilateral white matter oedema, which is usually symmetrical and totally reversible in 2–3 weeks. A 46-year-old man presented with a persistent headache and visual blurring in the right eye. On admission, the clinical examination revealed minimal unsteadiness of gait...
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Real-life effect of a microcrystalline tyrosine adjuvanted mite immunotherapy in patients with allergic rhinitis: Immunotherapy, Ahead of Print. Aim: Evaluate the effectiveness and safety of immunotherapy with Acarovac Plus® in a 1-year prospective multicentered real-life study. Methods: A total of 118 adults with allergic rhinitis sensitized to Dermatophagoides received subcutaneous immunotherapy with Acarovac Plus. Treatment outcomes were evaluated at baseline, 6 months and 1 year after treatment...
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GSE143274 Esculetin inhibits cancer cell glycolysis by binding tumor PGK2, GPD2, and GPIContributors : Song-Tao Wu ; Yan-Fang YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2)GPD2 and glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics and reverse dockingWe detected the binding constant of the active compound using microscale...
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GSE143274 Esculetin inhibits cancer cell glycolysis by binding tumor PGK2, GPD2, and GPIContributors : Song-Tao Wu ; Yan-Fang YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2)GPD2 and glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics and reverse dockingWe detected the binding constant of the active compound using microscale...
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Analysis of Anesthesia Methods in Percutaneous Kyphoplasty for Treatment of Vertebral Compression Fractures: Aim. Percutaneous kyphoplasty (PKP) is a routine operation for the treatment of vertebral compression fracture (VCF). Both local anesthesia and general anesthesia are widely used for PKP. However, which type of anesthesia is better for PKP still remains uncertain. This study aimed to find out whether local anesthesia or general anesthesia is more suitable for PKP. Methods. This is a retrospective...
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Genitourinary manifestations of endometriosis with emphasis on the urinary tract: AbstractEndometriosis is a common benign condition affecting women. The disease has a broad spectrum of presentations from incidental lesions in asymptomatic women to causing significant and debilitating morbidity in others. Ectopic endometrial glands are located in predictable locations throughout the pelvis, including implantation on the ovaries and in the rectouterine cul-de-sac. Less commonly, the urinary tract...
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Pharmacokinetics and safety of bilastine in children aged 6 to 11 years with allergic rhinoconjunctivitis or chronic urticaria: AbstractBilastine, a second-generation antihistamine, is approved in Europe for the treatment of allergic rhinoconjunctivitis and urticaria in adults and children aged ≥ 6 years. Pharmacokinetic data for children aged 6–11 years were extracted post hoc from a study in which children (2–11 years) with allergic rhinoconjunctivitis or urticaria received oral bilastine (10 mg/day)....
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Inflammatory anemia may be an indicator for predicting disease activity and structural damage in Chinese patients with rheumatoid arthritis: AbstractObjectivesThis study aimed to investigate the relationship of serum hemoglobin (HB) level with disease activity and structural damage in Chinese patients with rheumatoid arthritis (RA).MethodsA total of 890 RA patients and 890 normal subjects were enrolled in the case-control study. A HB threshold of< 110 g/L (women) and < 120 g/L (men) was used...
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A nurse-led paediatric oncology fast-track clinic proves a successful ambulatory intervention for patients: AbstractAimTo assess the impact of a pilot nurse-led paediatric oncology fast-track clinic (OFTC) for complications and side effects following chemotherapy within a paediatric tertiary hospital.MethodsProspective clinical data from the first 100 patients seen in the OFTC were compared with retrospective data of oncology patient presentations to the emergency department (ED) (over a 1-year period,...
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The use of complementary medicine in palliative care in France: an observational cross-sectional study: AbstractPurposePalliative care for cancer deals with physical, psychosocial, and spiritual issues faced by cancer patients, their families, communities, and healthcare providers. Research on complementary medicine (CM) use in France is limited despite high rates of reported CM use in other countries including by palliative patients. This study describes the use of CM by individuals receiving palliative...
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Quality of life, swallowing and speech outcomes after oncological treatment for mobile tongue carcinoma: AbstractBackgroundSurgical treatment of squamous cell carcinoma of the oral cavity (OSCC) has a high impact on patients' quality of life (QoL), as it variably affects their ability to speak, swallow and their social life. It is still debatable whether free flap tongue reconstruction has significant functional advantages over non-reconstructing techniques after tongue resection.MethodsA case-control...
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Biomolecules, Vol. 10, Pages 111: TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones: Biomolecules, Vol. 10, Pages 111: TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex HormonesBiomolecules doi: 10.3390/biom10010111Authors: M. Ángeles Martínez-García Miriam Ojeda-Ojeda Eulalia...
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Tuberculous Arthritis of the Knee with Rice Body Formation: A Report of a Rare Case: In this report, we present the case of a 53-year-old man with rice body formation in the right knee caused by tuberculous arthritis (TB arthritis). The patient visited our hospital in January 2018 with a seven-month history of swelling and pain in the right knee. He had no previous history of tuberculosis, and the results of the routine laboratory tests were within normal limits; he also tested negative for rheumatoid...
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Environmental PCB forensics: processes and issues: AbstractPCB forensic science is the process of identifying the source(s) of polychlorinated biphenyls (PCBs) at a site in the context of a legal proceeding to aid in identifying the party(s) responsible for the cost of environmental remediation. The PCB forensic scientist should assemble and examine all the evidence and then develop opinions about sources, discharges, deposition, fate, transport, environmental impact, and other issues at dispute...
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Label Free Diagnosis for Colorectal Cancer through Coffee Ring Assisted Surface Enhanced Raman Spectroscopy on Blood Serum: AbstractSurface enhanced Raman spectroscopy (SERS) is garnering considerable attentions for the swift diagnosis of pathogens and abnormal biological status, i.e. cancers. In this work, a simple, fast and inexpensive optical sensing platform is developed by the design of SERS sampling and data analysis. The pre‐treatment of spectral measurement employed gold nanoparticle colloid...
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Turbidimetric analysis of growth kinetics of bacteria in the laboratory environment using smartphone
Turbidimetric analysis of growth kinetics of bacteria in the laboratory environment using smartphone: AbstractFor different microbiological and pathological studies, it is often required to monitor the growth of bacteria in a cultured medium in the laboratory environment. UV–VIS spectrophotometer is commonly used to estimate the growth of bacterial cell population by measuring the absorbance at 600 nm over a period of time. Colony‐forming unit (CFU) is another approach which has been routinely performed...
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Autofluorescence imaging for recurrence detection in skin cancer post‐operative scars: AbstractThis clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in post‐operative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 post‐operative scars from 56 patients suspected of non‐melanoma skin cancer, with 8 patients (13 scars)...
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PAK1 silencing is synthetic lethal with CDK4/6 inhibition in gastric cancer cells via regulating PDK1 expression: AbstractGastric cancer (GC) is one of the most common malignancies worldwide. The prognosis of GC is unsatisfied owning to widespread metastasis. P21-activated kinase 1 (PAK1), a member of serine/threonine kinases, is associated with the progression of multiple types of human cancers. Here, we demonstrated that CDK4/6 inhibitor reduced GC cell viability and decreased PAK1 expression....
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Comparison of the effectiveness and safety of bioactive glass ceramic to allograft bone for anterior cervical discectomy and fusion with anterior plate fixation: AbstractRecently, a bioactive glass ceramic (BGC) has been developed for use as intervertebral cages for anterior cervical discectomy and fusion (ACDF). However, the effectiveness and safety of BGC cages remain to be evaluated. We completed a retrospective comparison of the radiological and clinical outcomes of 36 patients (52 levels) who...
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Biased agonists at the human Y 1 receptor lead to prolonged membrane residency and extended receptor G protein interaction: AbstractFunctionally selective ligands to address specific cellular responses downstream of G protein-coupled receptors (GPCR) open up new possibilities for therapeutics. We designed and characterized novel subtype- and pathway-selective ligands. Substitution of position Q34 of neuropeptide Y to glycine (G34-NPY) results in unprecedented selectivity over all other YR subtypes....
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"J Spec Oper Med"[jour]23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J Spec Oper Med"[jour]These pubmed results were generated on 2020/01/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.1.J Spec Oper Med. 2019 Winter;19(4):130-131.CoTCCC...
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Cancers, Vol. 12, Pages 157: Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based Study: Cancers, Vol. 12, Pages 157: Socio-Demographic Disparities in Gastric Adenocarcinoma: A Population-Based StudyCancers doi: 10.3390/cancers12010157Authors: Navpreet Rana Rohit Gosain Riccardo Lemini Chong Wang Emmanuel Gabriel Turab Mohammed Beas Siromoni Sarbajit Mukherjee Background: Gastric cancer is one of the leading causes of cancer-related mortality worldwide, accounting...
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Knockdown of SF3B1 inhibits cell proliferation, invasion and migration triggering apoptosis in breast cancer via aberrant splicingvia Latest Results for Breast CancerAbstractBackgroundSplicing factor 3b subunit 1 (SF3B1) was frequently reported to be significantly mutated in breast cancer. However, the status of SF3B1 expression, its function and molecular consequence in breast cancer remained unreported.MethodsImmunohistochemistry was used to assess SF3B1expression in 110 breast cancer samples....
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