ArticleThe efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure
Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Michihiro Nakada, Yoji Wani, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Yasuharu Sato & Kazunori Nishizaki
Pages: 1-5 | DOI: 10.1080/00016489.2019.1633019
Research ArticleEvolution of Meniere's Disease from MD 1.0, via MD 1.5, to MD 2.0
Tsung-Che Lu & Yi-Ho Young
Pages: 1-6 | DOI: 10.1080/00016489.2019.1632482
Is type 1 tympanoplasty effective in elderly patients? Comparison of fascia and perichondrium grafts
Serkan Cayir, Serkan Kayabasi & Omer Hizli
Pages: 1-5 | DOI: 10.1080/00016489.2019.1633018
The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure
Tomoyasu Tachibana ORCID Icon, Shin Kariya ORCID Icon, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, show all
Received 24 Apr 2019, Accepted 09 Jun 2019, Published online: 04 Jul 2019
Download citation https://doi.org/10.1080/00016489.2019.1633019
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Abstract
Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described.
Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy.
Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy.
Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration.
Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.
Chinese abstract
背景：虽然有关于OK-432硬化疗法对甲状舌管囊肿（TDC）疗效的研究, 但其对该疗法后外科手术的影响尚未得到适当描述。
目的：本研究旨在描述TDC患者OK-432硬化治疗的预后因素, 并探讨其对OK-432硬化治疗反应差的患者的后续手术程序和组织学特征的影响。
材料和方法：我们对20例使用OK-432硬化疗法治疗的TDC患者的病历进行了回顾性分析。
结果：20例患者中, OK-432硬化治疗有效5例（25.0％）。 OK-432对多房囊肿的有效率（9.1％）低于单房囊肿（44.4％）, 尽管不显著。 OK-432硬化剂治疗后, 5例患者接受手术治疗。接受和没有接受OK-432硬化疗法的患者的手术时间和出血量没有显著差异。根据囊壁组织学检查结果, 2例患者出现层状鳞状上皮, 2例未见淋巴细胞浸润。
结论和意义：OK-432硬化疗法是TDC的一种可接受的初始治疗方法, 特别是对于单房囊肿, 因为对手术过程没有影响。
Keywords: OK432 sclerotherapy, thyroglossal duct cyst, surgical results
Evolution of Meniere's Disease from MD 1.0, via MD 1.5, to MD 2.0
Tsung-Che Lu & Yi-Ho Young ORCID Icon
Received 25 Mar 2019, Accepted 03 Jun 2019, Published online: 04 Jul 2019
Download citation https://doi.org/10.1080/00016489.2019.1632482
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Abstract
Background: Elder Meniere's disease (MD) patients ultimately lose their vestibular function.
Objective: This study utilized an inner ear test battery to investigate evolution of MD.
Methods: Total 278 elder MD patients aged >65 years were divided into three groups. Ninety-four patients with bilateral MD (188 ears) were assigned to Group A. The remaining 184 patients with unilateral MD were further divided into two groups. Group B consisted of 20 affected ears with normal vestibular function on the opposite ears, while Group C indicated 184 unaffected ears. All patients underwent an inner ear test battery.
Results: Inner ear deficits in Group B declined from the cochlea via the saccule, utricle to semicircular canals. In contrast, Groups A and C did not significantly differ in the abnormality rates of cervical vestibular-evoked myogenic potential (cVEMP), ocular VEMP and caloric tests, indicating that Group C (unaffected ears) may partly share the same mechanism like Group A (affected ears), namely aging and hydropic effects.
Conclusion and significance: Evolution of MD may progress from unilateral MD (MD 1.0), via unilateral MD coupled with asymptomatic hydrops on opposite ear (MD 1.5), toward bilateral MD (MD 2.0), where the number 1.0-2.0 means the number of clinically affected ears.
Chinese abstract
背景：老年梅尼埃病（MD）患者最终会失去前庭功能。
目的：本研究利用内耳测试电池来探讨MD的演变。
方法：将278名年龄大于 65岁的MD患者分为3组。将94例双侧MD（188耳）患者分到A组。其余184例单侧MD患者进一步分为两组。 B组由20只受影响的耳朵组成, 对侧耳朵具有正常的前庭功能, 而C组则由184只未受影响的耳朵组成。所有患者均接受内耳测试电池。
结果：B组内耳缺陷从耳蜗经球囊、囊体到半规管一路减轻。相反, A组和C组在颈前庭诱发肌源性潜能（cVEMP）、眼VEMP和热量测试的异常率方面没有显著差异, 表明C组（未受影响的耳朵）可能部分地具有与A组（受影响的耳朵）相同的机制, 即衰老和积水效应。
结论和意义：MD的变化可能从单侧MD（MD 1.0）, 单侧MD加对侧耳无症状水肿（MD 1.5）, 发展成双侧MD（MD 2.0）, 其中数字1.0-2.0代表临床受影响的耳朵数。
Keywords: Aging effect, asymptomatic hydrops, cervical vestibular-evoked myogenic potential (cVEMP), ocular vestibular-evoked myogenic potential (oVEMP), Meniere's disease, the elderly
Is type 1 tympanoplasty effective in elderly patients? Comparison of fascia and perichondrium grafts
Serkan Cayir ORCID Icon, Serkan Kayabasi ORCID Icon & Omer Hizli ORCID Icon
Received 02 May 2019, Accepted 09 Jun 2019, Published online: 04 Jul 2019
Download citation https://doi.org/10.1080/00016489.2019.1633018
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Abstract
Background: Tympanoplasty is regularly performed in various ages but data about the procedure in elderly is insufficient.
Objectives: To compare the success rates and hearing outcomes of fascia and perichondrium grafts used for tympanoplasty in patients >65 years and to evaluate the prognostic factors affecting the success of tympanoplasty.
Methods: Reviewing records of 49 elderly patients underwent tympanoplasty, two groups were constituted: perichondrium (25 patients) and fascia (24 patients) groups. Ages, genders, perforation sides, type and location of perforation, graft success rates, functional success rates and air–bone gap (ABG) gains were compared.
Results: Overall graft success rate was 85.7%. After a mean follow-up of 23.3 ± 8.32 months, overall mean ABG gain was 11.33 ± 8.42 dB. Overall median postoperative ABG value (9 dB) was significantly lower compared to the median preoperative value (24 dB) (p < .001). Graft success rate was higher in perichondrium group (96%) compared to fascia group (75%) (p = .04). Functional success rate did not significantly differ between perichondrium (68%) and fascia groups (62.5%) (p = .68).
Conclusion and significance: Tympanoplasty is an effective procedure with a graft success rate of 85.7% in elderly. Both fascia and perichondrium are suitable materials; however, perichondrium had higher success rate.
Chinese abstract
背景：鼓室成形术通常对不同年龄段的患者进行, 但有关老年人手术的资料不足。
目的：比较用于65岁以上患者鼓室成形术的筋膜和软骨膜移植物的成功率和听力结果, 并评估影响鼓室成形术成功的预后因素。
方法：回顾49例接受鼓室成形术的老年患者的记录, 分为两组：软骨膜组（25例）和筋膜组（24例）。比较年龄、性别、穿孔侧、穿孔类型和位置、移植成功率、功能成功率和气骨间隙（ABG）增益。
结果：总移植成功率为85.7％。平均随访23.3±8.32个月后, 总体平均ABG增益为11.33±8.42 dB。总术后中位数ABG增益值（9 dB）显著低于术前中位值（24 dB）（p <.001）。与筋膜组（75％）相比, 软骨膜组（96％）的移植成功率更高（p = 0.04）。功能成功率在软骨膜（68％）和筋膜组（62.5％）之间没有显著差异（p = .68）。
结论和意义：鼓室成形术是一种有效的方法。老年人的移植成功率为85.7％。筋膜和软骨膜都是合适的材料；然而, 软骨膜的成功率更高。
Keywords: Elderly, tympanoplasty, fascia, perichondrium, success
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