Pathogen suppression by microbial volatile organic compounds in soils Wietse de Boer; Xiaogang Li; Annelein Meisner; Paolina Garbeva
Collaborative Solutions to Antibiotic Stewardship in Small Community and Critical Access HospitalsThe overuse and misuse of antibiotics affects patients in many ways, including by driving antibiotic resistance, a serious public health threat in the United States and around the world. To improve patient safety and address rising rates of resistance, an increasing number of health care facilities have created antibiotic stewardship programs (ASPs). ASPs have been successful in slowing the emergence...
Quantification of Student Radiographic Patient Positioning Using an Immersive Virtual Reality SimulationIntroduction Immersive virtual reality (VR) simulation environments facilitate novel ways for users to visualize anatomy and quantify performance relative to expert users. The ability of software to provide positional feedback before a practitioner progresses with subsequent stages of examinations has broad implications for primary and allied healthcare professionals, particularly with respect...
The Soul of the Stranger: Reading God and Torah from a Transgender Perspective. S J Crasnow Religions in Contemporary Africa: An Introduction Edward E Curtis, IV Buddhist Law Against the State? Representing Religion, Law, and Conflict Benjamin Schonthal Fatwa, Discursivity, and the Art of Ethical Embedding Omer Awass
The Mental Affordance Hypothesis, Tom McClelland
Exploring motivating factors among Iranian medical and nursing ESP language learners | Ali Hosseini, Nasrin Shokrpour, Krisda Chaemsaithong1634324 | DOI: 10.1080/23311983.2019.1634324
Rohan Deb Roy, Malarial Subjects: Empire, Medicine and Nonhumans in British India, 1820-1909 Pratik Chakrabarti Claire Trenery, Madness, Medicine and Miracle in Twelfth-Century England Stephen Gordon
Michael Alberti and the Medical Therapy of the Internal Senses Andreas Rydberg 'Close confinement tells very much upon a man': Prison Memoirs, Insanity and the Late Nineteenth- and Early Twentieth-Century Prison Hilary Marland "Alone in a Sea of Rib-Tips": Alvenia Fulton, Natural Health, and the Politics of Soul Food Travis A Weisse Treatment on Trial: Tanzania's National Tuberculosis Program, the International Union against Tuberculosis and Lung Disease, and the Road to DOTS, 1977-1991 Christoph...
Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults Bradley Ackerson ; Hung Fu Tseng; Lina S Sy; Zendi Solano; Jeff Slezak ... Older adults hospitalized with respiratory syncytial virus (RSV) or influenza were compared. RSV infection was associated with longer hospitalization and greater odds of pneumonia, intensive care unit admission, and 1-year mortality. Recognition of adult RSV disease is needed to facilitate future...
Can High Altitude Exacerbate a Remittent Alcohol Use Disorder in a Patient With a History of Panic Attacks?Background: Several studies have already investigated the brief and long-term neurological effects of exposure to high altitudes and the related sequelae of hypoxia on memory and cognition, but few authors have discussed the question of psychic symptoms during high-altitude activities. These authors suspect that the reexacerbation or worsening of psychiatric symptoms may well be the expression...
EDITORIALOutside the box of immunotherapy – new hope for patients with advanced urothelial cancerAnders UllénPages: 951-952 | DOI: 10.1080/0284186X.2019.1631478ORIGINAL ARTICLES: IMMUNOTHERAPYEfficacy and safety of immune checkpoint inhibitors in a Danish real life non-small cell lung cancer population: a retrospective cohort studyBirgitte Bjørnhart, Karin H. Hansen, Trine L. Jørgensen, Jørn Herrstedt & Tine SchyttePages: 953-961 | DOI: 10.1080/0284186X.2019.1615636Real-world data on PD-1 inhibitor...
Patients with spinal muscular atrophy use high percentages of trunk muscle capacity to perform seated tasksObjective To investigate trunk function during seated upper extremity tasks in patients with spinal muscular atrophy (SMA) type 2 and 3. Design 17 persons with SMA and 15 healthy controls (HC) performed several tasks when sitting unsupported, such as reaching (and placing) forward and sideward. Joint torque and muscle activity were measured during maximum voluntary isometric contractions (MVIC)....
Lychnophora pinaster ethanolic extract and its chemical constituents ameliorate hyperuricemia and related inflammationPublication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): Camila Martins de Sá Müller, Grazielle Brandão Coelho, Marcela Carolina de Paula Michel Araújo, Dênia Antunes Saúde-GuimarãesAbstractEthnopharmacological relevanceLychnophora pinaster, known as "Brazilian arnica" is used in folk medicine as alcoholic extract to treat inflammation, pain, rheumatism...
Anti-inflammatory and phytochemical evaluation of Combretum aculeatum Vent growing in SudanPublication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): Kamal M. Hamad, Manal M. Sabry, Sabah H. Elgayed, Abdel-Rahman El Shabrawy, Ahlam M. El-Fishawy, Gehad A. Abdel JaleelAbstractEthnopharmacological relevanceCombretum aculeatum Vent was traditionally used in Sudan, Eretria and Ethiopia as anti-inflammatory in case of skin inflammation, catarrh, wounds, scorpion stings...
Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) powdered leaves are effective in treating anxiety symptoms: A phase-2, randomized, placebo-controlled clinical trialPublication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): Fabio Carmona, Fernando Saraiva Coneglian, Priscila Alves Batista, Davi Casale Aragon, Mateus Andrea Angelucci, Edson Zangiacomi Martinez, Ana Maria Soares PereiraAbstractEthnopharmacological relevanceAloysia polystachya (Griseb.) Moldenke (Verbenaceae)...
Cardioprotective effects induced by hydroalcoholic extract of leaves of Alpinia zerumbet on myocardial infarction in ratsPublication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): Emanuel Tenório Paulino, Amanda Karine Barros Ferreira, Jessyka Carolina Galvão da Silva, Cintia Danielli Ferreira Costa, Salete Smaniotto, João Xavier de Araújo-Júnior, Edeíldo Ferreira Silva Júnior, Janaína Herbele Bortoluzzi, Êurica Adélia Nogueira RibeiroAbstractEthnopharmacology relevanceThe...
Cardioprotective effects induced by hydroalcoholic extract of leaves of Alpinia zerumbet on myocardial infarction in ratsPublication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): Emanuel Tenório Paulino, Amanda Karine Barros Ferreira, Jessyka Carolina Galvão da Silva, Cintia Danielli Ferreira Costa, Salete Smaniotto, João Xavier de Araújo-Júnior, Edeíldo Ferreira Silva Júnior, Janaína Herbele Bortoluzzi, Êurica Adélia Nogueira RibeiroAbstractEthnopharmacology relevanceThe...
Acid and bolus exposure in pediatric reflux disease according to the presence and severity of esophageal mucosal lesionsAbstractPurposeThe relationship between reflux index (RI) and bolus exposure parameters in multichannel intraluminal impedance (MII) has not been examined sufficiently among children. The significance of acid and bolus exposure in evaluating pediatric reflux disease (RD) was explored by focusing on mucosal lesions.MethodsWe conducted MII-pH on 28 patients (median age 8 years) with...
Abnormal serum vitamin A levels and retinoic acid receptor α expression patterns in children with anorectal malformationAbstractBackgroundAnorectal malformation (ARM) is known to be associated with maldevelopment of the enteric nervous system (ENS), and vitamin A (VA) and its metabolite retinoic acid (RA) play important roles in ENS development. Thus, our aim was to investigate serum VA levels in ARM newborns and RA receptor (RAR) expression in the rectum of ARM patients and animal models.MethodsSerum...
Letter to the Editor concerning: "the non-visualized appendix and secondary signs on ultrasound for pediatric appendicitis in the community hospital setting"Letter to the Editor concerning: "Inguinal hernia in neonates and ex-preterm: complications, timing and need for routine contralateral exploration"Letter to editor re: Baba T, Mukai M, Masuya R, et al. (2019) The long-term health-related quality of life in patients operated for choledochal cyst. Pediatr Surg Int 35:539–546Ultrasonography for...
Lower all-cause mortality rates in patients harboring pituitary carcinoma following the introduction of temozolomideAbstractObjectiveTo evaluate the impact of temozolomide (TMZ) introduction on the survival of patients with pituitary carcinoma (PC) compared to aggressive pituitary adenoma (APA).MethodsRetrospective analysis of the Surveillance Epidemiology and End-Results database (SEER), including patients diagnosed with PC or APA between 1973 and 2015. Age-adjusted Kaplan–Meier analyses were performed,...
Medullary thyroid carcinoma treated with percutaneous ultrasound-guided radiofrequency ablationAbstractPurposeMinimally invasive image-guided thermal ablation has been proposed as alternative to surgery for treatment of benign thyroid nodules and recurrent differentiated thyroid carcinoma. Here, we report for the first time the use of radiofrequency ablation (RFA) in a patient with non-metastatic medullary thyroid carcinoma (MTC) who did not undergo surgery due to high anesthesiological risk.Methods...
: a series of 31 cases emphasizing their clinicopathologic features and favorable prognosisAbstractPurposePrimary adrenal schwannoma (PAS) is a very rare benign tumor, and most of them have been described in case reports. This study aimed to analyze their distinct clinicopathologic features and follow-up data through the largest series yet.MethodsClinicopathologic features of 31 primary adrenal schwannomas were retrospectively studied. Imaging and histologic features were re-evaluated and summarized....
Differential expression of RET isoforms in normal thyroid tissues, papillary and medullary thyroid carcinomasAbstractPourposesWe investigated the expression of RET9 and RET51 isoforms in medullary (MTC), papillary (PTC) thyroid carcinoma, normal thyroid tissues, and pheochromocytoma (PHEO) to verify if these isoforms are present also in follicular thyroid cell-derived tissues, and if there is a differential expression of RET9 and RET51 in MTC.MethodsNineteen patients with MTC, 18 patients with PTC,...
Effect of 9 months of vitamin D supplementation on arterial stiffness and blood pressure in Graves' disease: a randomized clinical trialAbstractPurposeRisk of cardiovascular disease (CVD) is increased in Graves' disease (GD). CVD is predicted by increased pulse wave velocity (PWV) and blood pressure (BP). GD and these risk factors are all associated with lower levels of vitamin D. We aimed to assess the effect of supplemental vitamin D on PWV and BP in GD.MethodsIn a double-blinded trial, newly diagnosed...
Variants in MCT10 protein do not affect FT3 levels in athyreotic patientsAbstractPurposeSeveral single-nucleotide polymorphisms in genes encoding for transporters have been associated with serum thyroid hormone concentrations with inconsistent results. The aim of this study was to assess the clinical significance of the rs17606253 in SLC16A10 gene alone and in combination with the DIO2 Thr92Ala variation in athyreotic patients.MethodsOne-hundred patients submitted to total thyroidectomy and treated...
Histopathologischer Charcot-Score an intraoperativen Gewebeproben vom FußZusammenfassungHintergrundDie Charcot neuropathische Osteoarthropathie (CN) ist eine schwere Komplikation bei Patienten mit Polyneuropathie, die unbehandelt zu einer Zerstörung und einem Zusammenbruch des Fußes mit Ulzeration und Infektion führen kann. Die frühzeitige Diagnosestellung der CN ist essentiell und erfolgt anhand klinischer und radiologischer Parameter (Röntgen und MRT), da kein spezifischer und reliabler Test existiert.FragestellungErstellung...
Novel cortex lytic enzymes in Bacillus megaterium QM B1551 spores Bahja Al Riyami; Abhinaba Ghosh; Eric J Rees; Graham Christie
Design of fibronectin type III domains fused to an elastin-like polypeptide for the osteogenic differentiation of human mesenchymal stem cells Sujin Lee; Ji-Eun Kim; Hye-Jin Seo; Jun-Hyeog Jang
Metformin Treatment and Cancer Risk: Cox Regression Analysis with Time-Dependent Covariates of 320,000 Individuals with Incident Diabetes Mellitus Rachel Dankner ; Nirit Agay; Liraz Olmer; Havi Murad; Lital Keinan Boker ...
Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an accent pooled analysis of 7 studies J Taieb; Q Shi; L Pederson ; S Alberts; N Wolmark ... The negative impact of antibiotics on outcomes in cancer patients treated with immunotherapy: a new independent prognostic factor? A Elkrief; L Derosa; G Kroemer; L Zitvogel ; B Routy Optimizing panel-based tumor mutational burden (TMB)...
Metal ions doped into merocyanine form of coumarin derivatives: nonlinear optical molecular switchesAbstractIn the present study, DFT calculations are carried out on domestically designed 7-methyl-2-phenyl-5'H-spiro[chromene-4,2′-chromeno[3,4-e][1,3]oxazin]-5′-one spiropyran and merocyanine derivatives to recognize alkali and alkaline earth metal ions. Detection of these metal ions can be attained by exploiting the variation of the second-order nonlinear optical properties. Merocyanine forms of these...
Morphology and supramolecular structure characterization of cellulose isolated from heat-treated moso bambooAbstractThe change of physical and mechanical properties of bamboo after heat treatment has become a research hotspot recently. However, bamboo was usually used as a whole to investigate the reason why its properties changed. This study focused on cellulose, the skeleton substance of bamboo cell wall. Changes in morphology and supramolecular structure of cellulose isolated from heat-treated...
New Editor-in-ChiefTemperature-responsive PNDJ hydrogels provide high and sustained antimicrobial concentrations in surgical sitesAbstractLocal antimicrobial delivery is a promising strategy for improving treatment of deep surgical site infections (SSIs) by eradicating bacteria that remain in the wound or around its margins after surgical debridement. Eradication of biofilm bacteria can require sustained exposure to high antimicrobial concentrations (we estimate 100–1000 μg/mL sustained for 24 h)...
The Moral Complexity of Agriculture: A Challenge for Corporate Social ResponsibilityAbstractOver the past decades, the modernization of agriculture in the Western world has contributed not only to a rapid increase in food production but also to environmental and societal concerns over issues such as greenhouse gas emissions, soil quality and biodiversity loss. Many of these concerns, for example those related to animal welfare or labor conditions, are stuck in controversies and apparently deadlocked...
HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxiaAbstractObjectiveThe hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the pro-tumoral profile of M2 macrophages by a RAGE-dependent mechanism, it is tempting to evaluate the potential contribution of HMGB1 under hypoxia to restrain M2 macrophages mobility.MethodsCCR-2 expression...
Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in miceAbstractSepsis-induced myocardial depression (SIMD) is an early and frequent consequence of the infection-induced systemic inflammatory response syndrome. In homiotherms, variations in ambient temperature (Ta) outside the thermoneutral zone induce thermoregulatory responses mainly driven by a gradually increased sympathetic activity, which may affect disease severity. We hypothesized...
Atrial fibrillation is associated with alterations in HDL function, metabolism, and particle numberAbstractIncreased morbidity and mortality in atrial fibrillation (AF) are related to the pro-fibrotic, pro-thrombotic, and pro-inflammatory processes that underpin the disease. High-density lipoproteins (HDL) have anti-inflammatory, anti-oxidative, and anti-thrombotic properties. Functional impairment of HDL may, therefore, associate with AF initiation or progression. We studied indices of HDL quality...
Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injuryAbstractThe role of cyclooxygenase-2 (COX-2) in cardiovascular biology remains controversial. Although COX-2 has been reported to mediate the protective actions of late preconditioning, other studies show that it is also an important mediator of inflammation, toxic shock, and apoptosis, resulting in significant dysfunction and injury in several tissues. To determine whether increased...
Vascular Aging and Disease of the Large Vessels: Role of InflammationAbstractStructural and functional arterial properties commonly impair with aging process. These effects on vasculature could act at many levels from microcirculation to large vessels. Above normal aging process classic cardio-vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, etc.) accelerate the physiological process leading to premature structural and functional alterations that has also been termed early vascular...
Is the Oral Microbiome Associated with Blood Pressure in Older Women?AbstractIntroductionA possible role of the oral microbiome, specifically oral nitrate reducing flora, in blood pressure (BP) homeostasis, if proven etiologic in nature, could lead to novel mechanism-based therapy to improve hypertension prevention and control.AimThis cross-sectional study characterized and compared the oral microbiome between four study groups based on BP status among 446 postmenopausal women aged 53–82 years.MethodsThree...
Morning Surge and Peak Morning Ambulatory Blood Pressure Versus Automated Office Blood Pressure in Predicting Cardiovascular DiseaseAbstractIntroductionAutomated office blood pressure (AOBP) has been recently shown to predict equally well to ambulatory blood pressure (ABP), conventional office blood pressure (OBP) and home blood pressure (HBP), cardiovascular (CV) events among hypertensives.AimTo compare AOBP recording and ABP monitoring in order to evaluate morning blood pressure (BP) peak in predicting...
The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsAbstractIntroductionThere are current trials investigating the effect of resveratrol supplementation on endothelial function and blood pressures among patients with metabolic syndrome (MetS); however, the findings are controversial.AimThis systematic review and meta-analysis of randomized...
Aspirin Efficacy in Primary Prevention: A Meta-analysis of Randomized Controlled TrialsAbstractIntroductionThe role of aspirin as a means of primary prevention remains controversial.AimWe have conducted a meta-analysis of all randomized controlled trials (RCTs) to evaluate the role of aspirin in primary prevention.MethodsLiterature search was performed via PubMed, Embase, and the Cochrane Library for all related RCTs. All-cause mortality was the primary endpoint. Secondary endpoints included major...
Reviews Atypical Femur Fractures: Review of Epidemiology, Relationship to Bisphosphonates, Prevention, and Clinical Management Dennis M Black; Bo Abrahamsen; Mary L Bouxsein; Thomas Einhorn; Nicola Napoli Ovulation: Parallels With Inflammatory Processes Diane M Duffy; CheMyong Ko; Misung Jo; Mats Brannstrom ; Thomas E Curry, Jr. Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease Mathis Grossmann; Margaret E Wierman; Peter Angus; David J Handelsman Structural and Functional Biology...
Aspirin Efficacy in Primary Prevention: A Meta-analysis of Randomized Controlled TrialsAbstractIntroductionThe role of aspirin as a means of primary prevention remains controversial.AimWe have conducted a meta-analysis of all randomized controlled trials (RCTs) to evaluate the role of aspirin in primary prevention.MethodsLiterature search was performed via PubMed, Embase, and the Cochrane Library for all related RCTs. All-cause mortality was the primary endpoint. Secondary endpoints included major...
Exploring the dark genome: implications for precision medicineAbstractThe increase in the number of both patients and healthcare practitioners who grew up using the Internet and computers (so-called "digital natives") is likely to impact the practice of precision medicine, and requires novel platforms for data integration and mining, as well as contextualized information retrieval. The "Illuminating the Druggable Genome Knowledge Management Center" (IDG KMC) quantifies data availability from a wide...
Average Hourly Concentrations of Air Contaminants in Selected Urban, Town, and Rural SitesAbstractThe inhabitants of cities, towns, and villages are exposed to different levels of air pollution, which also vary throughout the day. Information regarding episodes of poor and good air quality enables planning to mitigate the risks and maximize the benefits of spending time outdoors. In this work, an analysis was made of the state of air quality 2012–2016, using data gathered from automatic measuring...
Assessments of Metals in Coastal Environments: State of ArtAbstractThis study is an overview of the assessments of metal contamination in coastal environments for the past five decades. Research articles with evaluations in sediments and biota were quantified and had their content visited for the registry of (1) the source of metals (anthropogenic or natural), (2) assessed country/territory, (3) groups of organisms assessed, (4) trophic transfer evaluation, (5) spatio-temporal variations, and (6)...
Spatial Distribution of Organophosphorus and Brominated Flame Retardants in Surface Water, Sediment, Groundwater, and Wild Fish in Chengdu, ChinaAbstractThe occurrence and spatial distribution of 13 organophosphorus flame retardants (OPFRs), 11 polybrominated diphenyl ethers (PBDEs), and eight novel brominated flame retardants (NBFRs) were investigated in Jinjiang river water, sediment, crucian carp, and groundwater in Chengdu, China. OPFRs were predominant and ubiquitous contaminants in the Jinjiang...
Increase in Contraceptive Counseling by Primary Care Clinicians After Implementation of One Key Question® at an Urban Community Health CenterAbstractIntroduction To provide quality family planning services and reduce racial and socioeconomic disparities in unintended pregnancy and pregnancy outcomes, primary care clinicians should routinely assess women's reproductive health needs and provide patient-centered contraceptive and preconception counseling. One Key Question® asks women if they would like...
Relationship Between Care Burden and Religious Beliefs Among Family Caregivers of Mentally Ill PatientsAbstractFamilies are considered as primary sources of care for individuals suffering from mental disorders. However, one of the major stresses in families is the infliction of a family member with mental illnesses causing dysfunction in health dimensions or generally their quality of life. Currently, most experts believe that religion can affect physical health and other aspects of human life. So,...
: The Transformative Power of a Sanctuary in TimeAbstractSabbath-keeping has several holistic health benefits when done for intrinsic reasons. Most research on Sabbath-keeping is about individuals where Sabbath-keeping is customary. This organic inquiry describes how a Sabbath promoted transformation for ten women where Sabbath-keeping was not the norm. Six themes emerged: Sabbath-keeping enhanced self-awareness, improved self-care, enriched relationships, developed spirituality, positively affected...
Dharmic Religions and Health: A Holistic Analysis of Global Health Literature Related to Hinduism, Buddhism, Sikhism and JainismAbstractBibliometrics and scientometrics are popular and novel disciplines providing information in publication trends in a certain academic field. Although there has been an increasing popularity in bibliometric studies, a limited number of reports have been published in religion and health literature. In this study, to the best of our knowledge we aimed to perform a first...
: A Matched Case–Control Study and Meta-AnalysisAbstractAlthough the association between religion/spirituality (R/S) and psychological outcomes is well established, current understanding of the association with cardiovascular disease remains limited. We sought to investigate the association between Islamic R/S and coronary heart disease (CHD), and place these findings in light of a meta-analysis. In this case–control study, 190 cases with non-fatal CHD were identified and individually matched with...
Correction to: Assessing Spiritual Well-Being in Residential Aged Care: An Exploratory ReviewThe original publication of this article (Drummond and Carey 2018) contained a missing reference in the "Results" section, second paragraph (p. 382). The corrected text has been given below.Correction to: Relationship Between Care Burden and Religious Beliefs Among Family Caregivers of Mentally Ill PatientsThe original version of this article unfortunately contained a mistake in the author name. The co-author...
"Like an Equal, Somehow" – What Young People Exposed to Family Violence Value in CounselingAbstractOne way for young people to reduce the risk of problems associated with having experienced family violence is to talk about their experiences with a counselor. However, little is known about how young people judge the quality of such relationships. The aim of this study was to analyze what young people describe as valuable in their relationship with the counselor with whom they talked about experiences...
On Linguistic history and language diversity in India: Views and counterviews By Sonal Kulkarni-JoshiDevelopment of typological classification and its relationship to microdifferentiation in ethnic IndiaAbstractThe history of the racial classification of the people of India can be looked at in three temporal phases: (1) at the national level, the initial studies of racial classification attempted along with the Census of India; (2) at the regional level, studies by anthropologists and statisticians...
Missing expectations: Windlass tourniquet use without formal training yields poor resultsBackground Despite significant attempts to educate civilians in hemorrhage control, the majority remain untrained. We sought to determine if laypersons can successfully apply one of three commercially available tourniquets; including those endorsed by the United States Military and the American College of Surgeons. Methods Pre-clinical graduate health science students were randomly assigned a commercially-available...
Effect of water-driven changes in rice rhizosphere on Cd lability in three soils with different pHPublication date: January 2020Source: Journal of Environmental Sciences, Volume 87Author(s): Jinjin Wang, Dongqin Li, Qin Lu, Yulong Zhang, Huijuan Xu, Xueli Wang, Yongtao LiAbstractPot experiments were conducted to evaluate the effect of water management, namely continuous flooding (CF), intermittent flooding (IF) and non-flooding (NF), on Cd phytoavailaility in three paddy soils that differed in pH...
Clinical Utility of Different Approaches for Detection of Late Pseudoprogression in Glioblastoma With O-(2-[18F]Fluoroethyl)-L-Tyrosine PETPurpose PET/CT using O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) has proven valuable in differentiating tumor recurrence and progression from therapy-induced changes. This study aimed to investigate the diagnostic performance of several analytic approaches in the setting of suspected late pseudoprogression (PsP) in glioblastoma multiforme (GBM). Methods Retrospective...
Evaluation of Pediatric Cardiac ICU Advanced Practice Provider Education and Practice VariationObjectives: The education, training, and scope of practice of cardiac ICU advanced practice providers is highly variable. A survey was administered to cardiac ICU advanced practice providers to examine specific variations in orientation format, competency assessment during and at the end of orientation, and scope of clinical practice to determine gaps in resources and need for standardization. Design: This...
Beneficial Effects of Ivabradine on Post-Resuscitation Myocardial Dysfunction In A Porcine Model of Cardiac ArrestBackground: Ivabradine selectively inhibits the If current, reducing the heart rate and protecting against myocardial ischemia/reperfusion injury. We investigated the effects of ivabradine on post-resuscitation myocardial function in a porcine model of cardiopulmonary resuscitation. Methods and Results: Ventricular fibrillation was induced and untreated for 8 minutes while defibrillation...
Decreasing Frontal Electroencephalogram Alpha Power and Increasing Sensitivity to Volatile Anesthetics Over 3 Surgeries Within 7 Months: A Case ReportDepth of anesthesia (DoA) monitors are widely used during general anesthesia to guide individualized dosing of hypnotics. Other than age and specific drugs, there are few reports on which comorbidities may influence the brain and the resultant electroencephalogram (EEG) of patients undergoing general anesthesia. We present a case of a patient undergoing...
Population management using gene drive: molecular design, models of spread dynamics and assessment of ecological risksAbstractCRISPR gene drive has recently been proposed as a promising technology for population management, including in conservation genetics. The technique would consist in releasing genetically engineered individuals that are designed to rapidly propagate a desired mutation or transgene into wild populations. Potential applications in conservation biology include the control of invasive...
Extending inferences from a randomized trial to a target populationNew methods for generalizability and transportability: the new normCoffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiersAbstractCoffee consumption has been associated with decreased mortality in previous studies. As aging, obesity, and lifestyle factors affect the risk of mortality, the association between coffee and mortality needs to be examined in various subpopulations by characteristics...
Synthetic microbial consortia for biosynthesis and biodegradation: promises and challengesAbstractFunctional differentiation and metabolite exchange enable microbial consortia to perform complex metabolic tasks and efficiently cycle the nutrients. Inspired by the cooperative relationships in environmental microbial consortia, synthetic microbial consortia have great promise for studying the microbial interactions in nature and more importantly for various engineering applications. However, challenges...
Computational psychopharmacology: a translational and pragmatic approachAbstractRationalePsychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders.ObjectivesThis brief review exemplifies this approach when applied to recent published studies of the effects of manipulating central dopaminergic and serotoninergic...
Initial Postoperative Hemoglobin Values and Clinical Outcomes in Transfused Patients Undergoing Noncardiac SurgeryBACKGROUND: Intraoperative red blood cell (RBC) transfusion is common, yet transfusion strategies remain controversial as pretransfusion hemoglobin triggers are difficult to utilize during acute bleeding. Alternatively, postoperative hemoglobin values may provide useful information regarding transfusion practices, though optimal targets remain undefined. METHODS: This is a single-center...
Initial Postoperative Hemoglobin Values and Clinical Outcomes in Transfused Patients Undergoing Noncardiac SurgeryBACKGROUND: Intraoperative red blood cell (RBC) transfusion is common, yet transfusion strategies remain controversial as pretransfusion hemoglobin triggers are difficult to utilize during acute bleeding. Alternatively, postoperative hemoglobin values may provide useful information regarding transfusion practices, though optimal targets remain undefined. METHODS: This is a single-center...
The Frequencies of Alleles of Single Nucleotide Substitutions in the CCK and CCK2R Genes in Some Russian Cattle BreedsAbstractAllele frequencies of three substitutions in the CCK (rs42891945 and rs42891946) and CCKBR (rs42670352) genes were identified in three Russian cattle breeds: Holstein (dairy), Bestuzhev (dual-purpose), and Kalmyk (beef). The most promising for further associative studies is the rs42670352 substitution in the CCKBR gene.Structure and Variability of the Pax3 and EDNRB Genes...
Constraints on song type matching in a songbirdAbstractIn an eastern population of song sparrows (Melospiza melodia), song type matching occurs at above chance levels but does not signal aggressiveness. One explanation for the apparent ineffectiveness of matching as a signal is that the occurrence of matching is constrained by internal rules for ordering the production of song types. This constraint hypothesis is tested here in an experiment in which the singing of territorial male song sparrows...
Outcomes for Basal Cell Carcinoma Treated With Vismodegib Extended Alternate Day DosingNo abstract availableCommentary on Transungual Excision of Glomus TumorsNo abstract availableTrends in the Incidence of Bowen Disease Based on a Single-Center Study in the NetherlandsBACKGROUND Incidence trends of nonmelanoma skin cancer show an increase. Few data have been published about the incidence of Bowen disease (BD). Three previous studies, conducted more than 15 years ago in North America, found large...
Placebo and nocebo effects on itch: a review of experimental methodsItch is a commonly experienced symptom of acute and chronic dermatological and systemic conditions. Placebo and nocebo effects, positive and negative effects experienced after both real and sham interventions, putatively due to positive or negative outcome expectancies, can have a significant impact on the experience of itch and its treatment. Experimental methods to induce and study placebo and nocebo effects on itch have been developed,...
Epidermal Growth Factor Receptor (EGFR)–Tyrosine Kinase Inhibitors (TKIs) Combined with Chemotherapy Delay Brain Metastasis in Patients with EGFR-Mutant Lung AdenocarcinomaAbstractBackgroundWhether epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) combined with chemotherapy can delay the occurrence of brain metastasis (BM) is unclear.ObjectiveThis retrospective study aimed to evaluate whether EGFR–TKIs combined with chemotherapy can delay BM and decrease the incidence of BM...
Additional concerns for the scavenging of anesthetic agents used for ICU sedationIntravenous administration of medications during an anesthetic: a deceptively simple processExpanding the usefulness of hemodynamic waveform analysis in the critically IllLimitations of near infrared spectroscopy (NIRS) in neurosurgical setting: our case experienceAbstractOne of the primary goals of anaesthesia in neurosurgical procedures is prevention of cerebral hypoxia leading to secondary neurological injury. Cerebral...
Influence of virtual monochromatic spectral image at different energy levels on motion artifact correction in dual-energy spectral coronary CT angiographyAbstractPurposeTo investigate the influence of virtual monochromatic spectral (VMS) CT images at different energy levels on the effectiveness of a motion correction technique (SSF) in dual-energy Spectral coronary CT angiography (CCTA).Materials and methods29 cases suspected of or diagnosed with coronary artery disease underwent Spectral CCTA using...
The Role of Simulation-Enabled Design Learning Experiences on Middle School Students' Self-generated Inherence HeuristicsAbstractIn science and engineering education, the use of heuristics has been introduced as a way of understanding the world, and as a way to approach problem-solving and design. However, important consequences for the use of heuristics are that they do not always guarantee a correct solution. Learning by Design has been identified as a pedagogical strategy that can guide individuals...
Next-generation whole exome sequencing of glioblastoma with a primitive neuronal componentAbstractGlioblastoma with a primitive neuronal component (GBM-PN) was renamed from glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET) in the new WHO classification of tumors of the central nervous system in 2016. GBM-PN is a rare variant of glioblastoma. There were not so many publications on the investigation of GBM-PN. We did whole exome sequencing for 11 GBM-PN cases and found that...
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