Early effects of eccentric contractions on muscle glucose uptake.

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Early effects of eccentric contractions on muscle glucose uptake.

J Appl Physiol (1985). 2018 Dec 13;:

Authors: Andersen OE, Nielsen OB, Overgaard K

Abstract
Muscle damaging eccentric exercise impairs muscle glucose uptake several hours to days after exercise. Little, however, is known about the acute effects of eccentric exercise on contraction- and insulin-induced glucose uptake. This study compares glucose uptake rates in the first hours following eccentric, concentric, and isometric contractions with and without insulin present. Isolated rat extensor digitorum longus muscles were exposed to either an eccentric, concentric, or isometric contraction protocol, and muscle contractions were induced by electric stimulation that were identical between contraction protocols. In eccentric and concentric modes length changes of 0.6 or 1.2 mm were used during contractions. Both contraction- and insulin-induced glucose uptake were assessed immediately and two hours after contractions. Glucose uptake increased significantly following all modes of contraction and was higher after eccentric contractions with a stretch of 1.2 mm compared to the remaining contraction groups when assessed immediately after contractions (eccentric(1.2mm) > eccentric(0.6mm), concentric(1.2mm), concentric(0.6 mm), isometric > rest; P<0.05). After two hours, contraction-induced glucose uptake was still higher than non-contracting levels but with no difference between contraction modes. The presence of insulin increased glucose uptake markedly, but this response was blunted by respectively 39-51% and 29-36% (p < 0.05) immediately and two hours after eccentric contractions stretched 1.2 mm when compared to concentric and isometric contractions. The contrasting early effects of eccentric contractions on contraction- and insulin-induced glucose uptake suggests that glucose uptake is impaired acutely following eccentric exercise due to reduced insulin responsiveness.

PMID: 30543500 [PubMed - as supplied by publisher]

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