[Hemorrhagic syndrome due to a heparin-like anticoagulant in a patient with systemic lupus erythematosus].

[Hemorrhagic syndrome due to a heparin-like anticoagulant in a patient with systemic lupus erythematosus].

Rev Med Interne. 2018 Nov 21;:

Authors: Ratti N, Cypierre A, Bezanahary H, Gondran G, Le Coustumier E, Palat S, Nadalon S, Liozon E, Ly K, Fauchais AL

Abstract
INTRODUCTION: In systemic lupus erythematosus, hemostasis disorders are mainly thrombotic, but more rarely hemorrhagic.
CASE REPORT: A 25-year-old man presented with a macrophagic activation syndrome revealing a systemic lupus erythematosus, secondarily complicated by a hemorrhagic syndrome ; biological investigations revealed an increase thrombin time and an activated partial thromboplastin time, normalized by protamin neutralization in vitro, thus confirming the presence of a heparin-like anticoagulant. The hemostasis balance normalized after the specific treatment of lupus.
CONCLUSION: This rare anomaly of hemostasis balance has been described in blood cancers and solid cancers. This is the first description of a case associated with an autoimmune connective tissue disorder such as lupus. After one year of follow-up, no diagnosis of blood or solid cancer was made.

PMID: 30471875 [PubMed - as supplied by publisher]

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