Anal human papillomavirus infection in kidney transplant recipients compared with immunocompetent controls

alexandrossfakianakis shared this article with you from Inoreader Anal human papillomavirus infection in kidney transplant recipients compared with immunocompetent controls Via Clinical Infectious Diseases Advance Access Abstract Background Kidney transplant recipients (KTRs) have increased risk of human papillomavirus (HPV)-related anogenital (pre-)cancers, including anal high-grade intraepithelial lesions (HSIL) and cancer. Previous studies on anal high-risk HPV among KTRs are sparse. Methods In a cross-sectional study, we included 247 KTRs and 248 controls from a dermatology department and five nephrology departments in Denmark during 2016–2017. All participants underwent a n anal cytobrush sample which was tested for HPV-DNA. Participants completed a questionnaire on lifestyle and sexual habits. We used logistic regression to estimate odds ratios (ORs) of anal hrHPV in KTRs compared with controls and risk factors for anal hrHPV in KTRs. Results The anal hrHPV prevalence was higher in female KTRs (45.5%) than controls (27.2%). Female KTRs had almost three-fold higher adjusted odds of anal hrHPV than controls (ORadjusted = 2.87, 95% confidence interval[CI], 1.57–5.22). In contrast, among men we did not observe increased prevalence or odds of anal hrHPV in KTRs compared with controls (prevalence: 19.4% vs 23.6%; ORadjusted = 0.85, 95%CI, 0.44–1.64). Among hrHPV positive KTRs, 63% and 52% of men and women, respectively, were infected with hrHPV types covered by the nonavalent HPV vaccine (16/18/31/33/45/52/58). Current smoking, >10 lifetime sexual partners, history of genital warts, and among men having had re ceptive anal sex, were risk factors for anal hrHPV in KTRs. Conclusion Female KTRs had increased risk of anal hrHPV compared with immunocompetent controls. Our findings highlight that pre-transplant HPV vaccination should be considered to prevent anal HSIL and cancer caused by anal hrHPV infection in KTRs. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

HIGH RATE OF HCV REINFECTION AMONG RECENTLY INJECTING DRUG USERS: RESULTS FROM THE TRAP HEP C PROGRAM – A PROSPECTIVE NATIONWIDE, POPULATION-BASED STUDY

alexandrossfakianakis shared this article with you from Inoreader HIGH RATE OF HCV REINFECTION AMONG RECENTLY INJECTING DRUG USERS: RESULTS FROM THE TRAP HEP C PROGRAM – A PROSPECTIVE NATIONWIDE, POPULATION-BASED STUDY Via Clinical Infectious Diseases Advance Access Abstract Background The Treatment as Prevention for Hepatitis C program started in 2016 in Iceland, offering treatment with direct-acting antivirals to hepatitis C virus (HCV)-infected individuals. Reinfections through injection drug use (IDU) can hamper elimination efforts. We determined reinfection rates (RIR) of HCV among patients in the program. Methods Clinical data were gathered prospectively. The study cohort consisted of HCV-cured patients with an estima ted sustained virologic response between February 1st 2016 and November 20th 2018, with follow-up until November 20th 2019. The observation period and time until reinfection was estimated using a single random point imputation method coupled with Monte Carlo simulation. The RIR was expressed as reinfections/100 person-years (PYs). Results 640 treatments of 614 patients (417 males, mean age 44.3 years) resulted in cure, with 52 reinfections subsequently confirmed in 50 patients (37 males). Follow-up was 672.1 PYs with median time to reinfection of 231.7 days. History of IDU was reported by 523 patients (84.8%) and recent IDU with 220 (34.4%) treatments. Stimulants were the preferred injected drug in 85.5% of patients with history of IDU. The RIR was 7.7/100 PYs. Using multivariate Cox proportional hazards models for interval-censored data, age (HR 0.96, 95% CI 0.94-0.99) and recent IDU (HR 2.91, 95% CI 1.48-5.76) were significantly associated with reinfection risk. Conclusions The RIR is high in a setting of widespread stimulant use, particularly in young people with recent IDU. Regular follow up is important among high-risk populations to diagnose reinfections early and reduce transmission. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Subsequent anti-myeloma therapy after idecabtagene vicleucel treatment in patients with relapsed/refractory multiple myeloma: A single center analysis

alexandrossfakianakis shared this article with you from Inoreader Subsequent anti-myeloma therapy after idecabtagene vicleucel treatment in patients with relapsed/refractory multiple myeloma: A single center analysis Via Blood Cancer Journal - Issue - nature.com science feeds Blood Cancer Journal, Published online: 19 April 2022; doi:10.1038/s41408-022-00662-0 Subsequent anti-myeloma therapy after idecabtagene vicleucel treatment in patients with relapsed/refractory multiple myeloma: A single center analysis View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars

alexandrossfakianakis shared this article with you from Inoreader Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars Via ScienceDirect Publication: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Publication date: Available online 18 April 2022 Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Masatoshi Hirayama, Kazushige Inoue, Hidetaka Arita, Nozomu Takahashi, Hikaru Nakashima, Junki Sakata, Manabu Maeshiro, Yuka Nagao, Shunsuke Gohara, Keisuke Yamana, Yuichiro Matsuoka, Akira Yuno, Masafumi Nakamoto, Kenta Kawahara, Masashi Nagata, Akiyuki Hirosue, Daiki Fukuma, Ryoji Yoshida, Hideki Nakayama View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Risk Factors and Complications Associated with Early Oral Intake in Patients Undergoing Microvascular Free Flap Reconstruction of the Oral Cavity: A Single-institution, Retrospective Study

alwin shared this article with you from Inoreader Risk Factors and Complications Associated with Early Oral Intake in Patients Undergoing Microvascular Free Flap Reconstruction of the Oral Cavity: A Single-institution, Retrospective Study Via Journal of Oral and Maxillofacial Surgery The objective of the study is to assess postoperative complications associated with early PO after free flap reconstruction of the oral cavity and to define clinical predictors for early PO. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Does the Modified Frailty Index (mFI-5) Predict Adverse Outcomes in Maxillofacial Fracture Repair?

alwin shared this article with you from Inoreader Does the Modified Frailty Index (mFI-5) Predict Adverse Outcomes in Maxillofacial Fracture Repair? Via Journal of Oral and Maxillofacial Surgery Frailty has been recognized as a predictor of postoperative adverse outcomes in many surgical subspecialties. The purpose of this study was to evaluate the relationship between frailty and complications in patients undergoing operative repair of facial fractures. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study

alwin shared this article with you from Inoreader Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study Via Journal of Oral and Maxillofacial Surgery To investigate the efficacy and safety of concentrated growth factor fibrin (CGF) for the extraction of mandibular third molars. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.