Blog Archive

Αλέξανδρος Γ. Σφακιανάκης

Thursday, November 4, 2021

Prevalence and Risk Factors for Multifocality in Pediatric Thyroid Cancer

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This cohort study aims to determine the prevalence and risk fac tors for multifocal disease in pediatric patients with papillary thyroid carcinoma.
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Head and Neck Cancer Posttreatment Surveillance Questions

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The role of close follow-up of patients with head and neck cancer after completion of therapy is unquestionably important, but questionably vague. While National Comprehensive Cancer Network guidelines on the timing of surveillance are published, the lack of high-level evidence on the effectiveness of these protocols and the changing landscape of HPV-associated cancers on survivorship have expectedly raised the collective eyebrow on their suitability in the current era. As more patients with head and neck cancer benefit from a quantity-of-li fe perspective from more advanced radiation delivery systems, chemoimmunotherapy breakthroughs, and improved surgical techniques, the impending impact this has on resources needed in surveillance, such as costs associated with specialty examinations and anatomic imaging studies, as well as the psychosocial and financial impact on the patients themselves, is becoming more prevalent. In the Original Investigation by Chen et al, the authors seek to identify physician and patient-related barriers to deintensifying surveillance practices and provide suggestions on facilitating change.
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Local Anesthetic Infusion for Improving Pain From Head and Neck Cancer Surgery—Reply

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In Reply We thank Drs Rahman and Mendelsohn for their interest in our recent study. The performance of a neck dissection has been shown to be associated with great and potentially long-lasting pain and is therefore also listed in the German S3 guideline for acute postoperative pain as a surgical procedure with expected high pain levels. Multimodal pain therapy strategies used in various surgical disciplines incorporate the continuous application of local anesthesia in surgical wound cavities. Therefore, this mechanism seems to be reasonable also in the wound cavity after neck dissection. Furthermore, anesthesia of the superficial branches of the cervical plexus also represents an effective technique of anesthesia of the entire lateral neck as it is also performed during local anesthetic procedures on the cervical vessels. Brown has reported that the anterior rami of the second to fourth cervical nerves may also interconnect with peripheral branches of the trigeminal, facial, glossopharyngeal, and hypoglossal nerves. Thus, effective pain relief by a locally applied anesthetic also seems reasonable and effective in the context of neck dissection involving the cervical plexus and, in our opinion, may achieve more than pure anesthesia of the skin of the neck only.
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Clinician Attitudes and Beliefs About Deintensifying Head and Neck Cancer Surveillance

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This qualitative study surveys otolaryngologists and radiation oncologists regarding their opinions on deintensification of surveillance in patients with diagnosed head and neck cancer.
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Predictive Value of a Genomic Classifier in Indeterminate Thyroid Nodules Based on Nodule Size

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This case series examines the accuracy of a genomic classifier in diagnosis and treatment of patients with indeterminate thyroid nodules.
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Endoscopic cauterisation and injection of Voicegel for treatment of congenital pyriform fossa sinus tracts

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Acta Otorhinolaryngol Ital. 2021 Oct;41(5):432-435. doi: 10.14639/0392-100X-N1433.

ABSTRACT

OBJECTIVE: To demonstrate our experience in treating pyriform fossa sinus tracts (PFST) using a novel technique of endoscopic cauterisation of the pyriform fossa sinus opening combined with injection of sodium carboxymethylcellulose gel (VoiceGel) lateral to the tract to encourage tight closure.

METHODS: Over a 48-month period, we used this technique on 11 patients who were diagnosed with PFST at BC Children's Hospital, a tertiary paediatric centre in Vancouver, BC, Canada.

RESULTS: The 11 patients included 8 males and 3 females, and mean age at presentation was 69 months (range 22-108 months). Mean time from beginning of symptoms till diagnosis was 15 months (range 12-22 months). Ten PFST were on the left side of the neck and one on the right. Nine patients presented with recurrent neck infections and two had suppurative thyroiditis. All p atients had endoscopic cauterisation of their PFST opening combined with injection of carboxymethylcellulose lateral to the sinus tract to cause tract collapse. Mean follow up was 15.8 months (range 8-24). All patients are asymptomatic without recurrence at the last follow-up visit. No post-operative complications were reported.

CONCLUSIONS: Endoscopic management of paediatric PFST combined with the injection of sodium carboxymethylcellulose gel lateral to the sinus tract appears to be a safe and effective treatment option for PFST.

PMID:34734578 | DOI:10.14639/0392-100X-N1433

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The 5‐HT1A receptor agonist, 8‐OH‐DPAT, Attenuates Long‐Lasting Pain in Imiquimod‐Induced Psoriasis in Mice.

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ABSTRACT

Psoriasis pain is a common symptom underestimated and rarely evaluated in psoriasis clinical trials. This work aimed to investigate if the development of secondary chronic allodynia and hyperalgesia in the imiquimod (IMQ)-induced psoriasis mice model could be modulated by anti-inflammatory agents and compound 48/80 (C48/80) and to determine whether the activation of 5-HT1A receptor modulates these nociceptive behaviors. C57BL/6 male mice were treated with 5% IMQ for 7 days. The paw withdrawal responses to von Frey filaments (10 and 250 mN) were used to assess the allodynia and hyperalgesia. Nociceptive behaviors were also evaluated using ketorolac 15 mg/kg s.c; adalimumab 10 mg/kg s.c., and C48/80 10 mg/kg i.p. Then, the serum serotonin and the impact of 8-OH-DPAT (1 mg/kg s.c), a 5-HT1A receptor agonist, on long-lasting pain were examined. Mice receiving IMQ showed enhanced nociception, which decreased with all tested compounds. The serum serotonin in the IM Q-group showed a significant decrease (947.042 ng/ml) regarding the control group (1143.68 ng/ml). The pre-treatment with 8-OH-DPAT alleviated pain-related behaviors. These results suggest that the long-lasting pain resulting from psoriasis inflammation is also associated with the serotonergic system. The 5-HT1A receptor should be further explored as a potential therapeutic target for psoriasis pain modulation.

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