Tacrolimus 0.03% ointment treatment in exfoliative cheilitis: a randomised controlled clinical trial and monitoring blood concentration

xloma.fota13 shared this article with you from Inoreader Tacrolimus 0.03% ointment treatment in exfoliative cheilitis: a randomised controlled clinical trial and monitoring blood concentration Via Oral Pathology & Medicine Abstract Background Tacrolimus has been used to treat various inflammatory skin diseases, but its safety for topical application on the oral mucosa is unknown. Exfoliative cheilitis (EC) is a chronic inflammatory disorder of the lips characterised by repeated scaling; it is difficult to manage. The aim of this study was to assess the efficacy and safety of tacrolimus 0.03% ointment as a topical treatment in patients with EC. Methods In this randomised controlled clinical trial, 40 patients with EC were randomly assigned to receive either tacrolimus 0.03% ointment (experimental group, n = 20) or triamcinolone acetonide 0.1% cream (control group, n = 20) treatment for a 3‐week period. Medication was administered in 3, 2, and 1 daily doses during the first, second, and third weeks, respectively. The patients with complete healing were followed up for 3 months. The clinical outcomes were measured, including the scores regarding signs (scale, dryness, rhagades, and swelling) and symptoms (rough, dry, pain, pruritus, and burning sensation) at every visit. Blood concentrations of tacrolimus were assessed. Results After the 3‐week treatment, healing rates of scale in the experimental and control groups were 65% and 10%, respectively (P = 0.018). Improvement in all signs and two symptoms (rough, pruritus) was much greater in the experimental group (P < 0.05). The 3‐month recurrence rate was higher in the control group (P = 0.029). Tacrolimus blood concentrations were in the safe range (< 5 ng/mL). Conclusion Topical tacrolimus 0.03% ointment has good short‐term efficacy and safety for treating EC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Elective neck dissection in primary parotid carcinomas: a systematic review and meta‐analysis

xloma.fota13 shared this article with you from Inoreader Elective neck dissection in primary parotid carcinomas: a systematic review and meta‐analysis Via Oral Pathology & Medicine Abstract Background To estimate the rate of occult cervical lymph node metastases in cN0 patients affected by primary parotid carcinomas and to scrutinize the evidence on the indication and extent of elective neck dissection in these neoplasms. Methods Medline, Embase, Web of Science, Cochrane Library and Scopus were searched until August 31, 2020, to identify studies reporting the use of elective neck dissection in the management of malignant parotid tumours. The PRISMA checklist was used. A single arm meta‐analysis was then made to determine the pooled rate of occult lymph node metastases. Risk of bias of the included studies was assessed through the ROBINS‐E tool. Results The initial search returned 20541 articles, of which twelve met the inclusion criteria and were included in the meta‐analysis. They comprised 1310 patients with parotid carcinoma, of whom 542 cN0 underwent elective neck dissection, which led to the diagnosis of lymph node metastasis (pN+/cN0) in 113 cases. Meta‐analysis of the results of elective neck dissection showed an overall rate of occult metastases of 0.22 (99% CI: 0.14‐0.30). Locally advanced or high‐grade tumors were the commonest indications for elective neck dissection in the included studies. The most dissected lymph node levels were I‐II‐III, and level II was the commonest site of occult nodal metastases. Conclusions An occult metastasis rate of 0.22 (99% CI: 0.14‐0.30) represents a not negligible percentage value, which should encourage further research to outline the most appropriate elective neck management in cN0 patients with parotid carcinomas. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Malocclusion in individuals with osteogenesis imperfecta: A systematic review and meta‐analysis

xloma.fota13 shared this article with you from Inoreader Malocclusion in individuals with osteogenesis imperfecta: A systematic review and meta‐analysis Via Oral Diseases Abstract Objective To evaluate whether individuals with osteogenesis imperfecta (OI) are more affected by malocclusion than individuals without OI. Materials and Methods Searches in PubMed, Ovid, Web of Science, Scopus, Lilacs and gray literature were performed. Data extraction was conducted by two researchers. Risk of bias assessment employing the Newcastle‐Ottawa Scale and meta‐analysis were conducted. Results were provided with mean difference (MD), odds ratio (OR) and 95% confidence interval (CI). Strength of evidence was determined. Results Six cross‐sectional studies were included. In comparison with individuals without OI, the group with OI had 19.69‐fold greater chance of exhibiting Angle Class III malocclusion (OR = 19.69, CI: 9.00–43.09) and presenting anterior crossbite greater (MD = 6.08, CI: 2.40–9.77). Individuals without OI had a significantly greater ANB angle (MD = 3.88, CI: 1.15–6.61) and SNA angle (MD = 2.11, CI: 0.24–3.98) in comparison with those with OI. No difference between groups was found for SNB (MD = −0.50, CI: −2.21 to 1.21) and open bite (MD = 0.98, CI: −0.29 to 2.25). Most studies included had moderate methodological quality. Strength of evidence was low or very low. Conclusions The occurrence of Angle Class III malocclusion and anterior crossbite was greater among individuals with OI compared to those without OI. These findings can assist stakeholders about the occlusal abnormalities affecting OI individuals. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hyalomma anatolicum resistance against ivermectin and fipronil is associated with indiscriminate use of acaricides in southwestern Balochistan, Pakistan

xloma.fota13 shared this article with you from Inoreader Hyalomma anatolicum resistance against ivermectin and fipronil is associated with indiscriminate use of acaricides in southwestern Balochistan, Pakistan Via Latest Results for Parasitology Research Abstract Ivermectin and fipronil have been used regularly to control the hard tick Hyalomma anatolicum (Acari: Ixodidae) in domestic ruminants for more than a half-decade in Balochistan, Pakistan. Inappropriate and indiscriminate use of these acaricides has resulted in the development of resistances in tick species. In this work, acaricides (ivermectin and fipronil) resistance was evaluated in H. anatolicum through in vitro and in vivo bioassays in a horse farm of Quetta, Balochistan province, Pakistan. A participatory epidemiological survey was conducted to assess potential risk factors associated with the development of acaricide resistance in H. anatolicum. The results of the epidemiological survey revealed that the horse keepers did not follow the manufacturer's instructions for the use of acaricides and applied indiscriminate doses of acaricides. The results of in vitro bioassays (adult immersion test and larval immersion test) showed tha t fipronil and ivermectin have protective efficacy against H. anatolicum. The results of in vivo bioassay (adult-tick mortality assay) revealed that fipronil had a higher efficacy (78.16%) than ivermectin (49.94%). More than 80% of tick mortality was not achieved in any bioassays, even for the highest acaricide concentration (100 ppm), which suggests the development of acaricide resistance against fipronil and ivermectin. This study highlights the urgency to implement a country-wide awareness about resistance monitoring and effective tick control. Graphical abstract View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Two case reports of Mycobacterium marinum infection with psoriatic arthritis treated by tumor necrosis factor‐α inhibitors

xloma.fota13 shared this article with you from Inoreader Two case reports of Mycobacterium marinum infection with psoriatic arthritis treated by tumor necrosis factor‐α inhibitors Via The Journal of Dermatology View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Successful treatment of acne fulminans with the combination of prednisolone and diaminodiphenylsulfone

xloma.fota13 shared this article with you from Inoreader Successful treatment of acne fulminans with the combination of prednisolone and diaminodiphenylsulfone Via The Journal of Dermatology View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The curious case of IL‐33 in homeostasis and infection

xloma.fota13 shared this article with you from Inoreader The curious case of IL‐33 in homeostasis and infection Via European Journal of Immunology Abstract The importance of interleukin (IL)‐33 in promoting effective antiviral immune responses is evident, yet the critical cellular sources of IL‐33 in homeostasis and infection are largely unknown. In this issue of the European Journal of Immunology, Aparicio‐Domingo et al. [Eur. J. Immunol. 2021. 51: XX‐XX] explore the main source of IL‐33 expression in lymph nodes (LNs) and dissect its role in LN homeostasis and antiviral adaptive immune response. The authors reveal that fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) are both producing IL‐33 in steady‐state LNs. Remarkably, however, by using cell‐type specific deletion approaches, the authors demonstrate that exclusively FRCs, and not LECs, are the critical cellular source for promoting antiviral CD8+ T cell responses upon infection. These findings provide an important insight into the role of specific LN stromal cell subsets as potent modulators of antiviral immunity . This article is protected by copyright. All rights reserved View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.