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Αλέξανδρος Γ. Σφακιανάκης

Tuesday, November 17, 2020

Posterior Pharyngeal Wall Tuberculosis-A Forgotten Entity Mimicking Malignancy.

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Posterior Pharyngeal Wall Tuberculosis-A Forgotten Entity Mimicking Malignancy.

Ear Nose Throat J. 2020 Nov 11;:145561320973781

Authors: Kairo AK, Kajal S, Shamim SA, Barwad A

Abstract
BACKGROUND: Tuberculosis (TB) of posterior pharyngeal wall (PPW), either primary or secondary, is extremely rare and can mimic malignancy in elderly patients.
CASE REPORT: A 36-year-old female patient presented with complains of nonhealing ulcer at the back of her throat for 4 months. On examination, there was an ulceroproliferative growth covered with slough over PPW. Positron emission tomography scan showed uptake in PPW. There was no uptake in any other part of body. A biopsy from PPW lesion showed epithelioid cell granulomas with Langhans type giant cells. Auramine-rhodamine staining showed few beaded bacilli consistent with TB.
CONCLUSION: Tuberculosis of PPW is an extremely uncommon entity and can mimic malignancy. It should be kept as one of the differential diagnosis as it can be cured solely by giving anti-tubercular therapy.

PMID: 33174490 [PubMed - as supplied by publisher]

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Concomitant Dehiscences of the Temporal Bone: A Case-Based Study.

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Concomitant Dehiscences of the Temporal Bone: A Case-Based Study.

Ear Nose Throat J. 2020 Nov 11;:145561320973782

Authors: Barbara M, Margani V, Voltattorni A, Monini S, Covelli E

Abstract
Otic capsule dehiscences create a pathological third window in the inner ear that results in a dissipation of the acoustic energy consequent to the lowered impedance. Superior semicircular canal dehiscence (SSCD) was identified by Minor et al in 1998 as a syndrome leading to vertigo and inner ear conductive hearing loss. The authors also reported the relation between the dehiscence and pressure- or sound-induced vertigo (Tullio's phenomenon). Prevalence rates of SSCD in anatomical studies range from 0.4% to 0.7% with a majority of patients being asymptomatic. The observed association with other temporal bone dehiscences, as well as the propensity toward a bilateral or contralateral "near dehiscence," raises the question of whether a specific local bone demineralization or systemic mechanisms could be considered. The present report regard a case of a patient with a previous episode of meningitis, with a concomitant bilateral SSCD and tegmen tympani dehiscence from the side of meningitis. The patient was affected by dizziness, left moderate conductive hearing loss, and pressure/sound-induced vertigo. Because of disabling vestibular symptoms, the patient underwent surgical treatment. A middle cranial fossa approach allowed to reach both dehiscences on the symptomatic side, where bone wax and fascia were used for repair. At 6 months from the procedure, hearing was preserved, and the vestibular symptoms disappeared.

PMID: 33175590 [PubMed - as supplied by publisher]

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[Deliberations on the (125)I seed activity influence on dosimetry significance for abdominal and pelvic tumors brachytherapy].

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[Deliberations on the (125)I seed activity influence on dosimetry significance for abdominal and pelvic tumors brachytherapy].

Zhonghua Yi Xue Za Zhi. 2020 Nov 10;100(41):3204-3206

Authors: Wang J, Liang YS, Zhang HT

PMID: 33167106 [PubMed - indexed for MEDLINE]

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Thyroid Lobectomy for Low to Intermediate Risk Differentiated Thyroid Cancer.

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Thyroid Lobectomy for Low to Intermediate Risk Differentiated Thyroid Cancer.

Cancers (Basel). 2020 Nov 06;12(11):

Authors: Hartl DM, Guerlain J, Breuskin I, Hadoux J, Baudin E, Al Ghuzlan A, Terroir-Cassou-Mounat M, Lamartina L, Leboulleux S

Abstract
Many recent publications and guidelines have promoted a "more is less" approach in terms of treatment for low to intermediate risk differentiated thyroid cancer (DTC), which comprise the vast majority of thyroid cancers: less extensive surgery, less radioactive iodine, less or no thyroid hormone suppression, and less frequent or stringent follow-up. Following this approach, thyroid lobectomy has been proposed as a means of decreasing short- and long-term postoperative morbidity while maintaining an excellent prognosis for tumors meeting specific macroscopic and microscopic criteria. This article will examine the pros and cons of thyroid lobectomy for low to intermediate risk cancers and discuss, in detail, criteria for patient selection and oncological outcomes.

PMID: 33171949 [PubMed]

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Axillary lymph node metastases from thyroid carcinoma: Report of seven cases.

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Axillary lymph node metastases from thyroid carcinoma: Report of seven cases.

Auris Nasus Larynx. 2020 Nov 07;:

Authors: Suehiro A, Nagahara K, Moritani S, Omori K

Abstract
Axillary lymph node metastasis (ALNM) of well- or poorly-differentiated thyroid cancer is rare. Notably, there are only 14 single case reports available; therefore, the mechanism of metastasis is unclear at this point. Because we encountered seven cases at a single institution, we were able to infer the mechanism of ALNM of thyroid cancer. The seven cases treated at our institution were analyzed retrospectively. In addition, 14 cases reported from other institutions were reviewed. All seven patients we treated and the 10 patients, among the 14, from other institutions were postoperative recurrences. All seven patients we treated had lymph node metastases near the venous angle, and invasive manipulation had been performed during the previous surgery. Therefore, we can presume that fibrosis at the venous angle caused by ablative surgery or tumor invasion could have resulted in anomalous lymphatic flow from the neck to the axilla. Hence, the subclavian region would probably need to be dissected besides axillary dissection. All 21 cases underwent surgical treatment for ALNM. Metastatic lymph nodes in the venous angle, subclavian or axilla, occasionally invade or adhere to the vessels. Hence, a surgical strategy is required in those cases rather than molecular targeted therapy or radioactive iodine irradiation.

PMID: 33172762 [PubMed - as supplied by publisher]

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Senescent Decline in Verbal-Emotion Identification by Older Hearing-Impaired Listeners - Do Hearing Aids Help?

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Senescent Decline in Verbal-Emotion Identification by Older Hearing-Impaired Listeners - Do Hearing Aids Help?

Clin Interv Aging. 2020;15:2073-2081

Authors: Ruiz R, Fontan L, Fillol H, Füllgrabe C

Abstract
Purpose: To assess the ability of older-adult hearing-impaired (OHI) listeners to identify verbal expressions of emotions, and to evaluate whether hearing-aid (HA) use improves identification performance in those listeners.
Methods: Twenty-nine OHI listeners, who were experienced bilateral-HA users, participated in the study. They listened to a 20-sentence-long speech passage rendered with six different emotional expressions ("happiness", "pleasant surprise", "sadness", "anger", "fear", and "neutral"). The task was to identify the emotion portrayed in each version of the passage. Listeners completed the task twice in random order, once unaided, and once wearing their own bilateral HAs. Seventeen young-adult normal-hearing (YNH) listeners were also tested unaided as controls.
Results: Most YNH listeners (89.2%) correctly identified emotions compared to just over half of the OHI listeners (58.7%). Within the OHI group, verbal emotion identification was significantly correlated with age, but not with audibility-related factors. The number of OHI listeners who were able to correctly identify the different emotions did not significantly change when HAs were worn (54.8%).
Conclusion: In line with previous investigations using shorter speech stimuli, there were clear age differences in the recognition of verbal emotions, with OHI listeners showing a significant reduction in unaided verbal-emotion identification performance that progressively declined with age across older adulthood. Rehabilitation through HAs did not provide compensation for the impaired ability to perceive emotions carried by speech sounds.

PMID: 33173288 [PubMed - in process]

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Current surgical treatment of intermediate risk differentiated thyroid cancer: a systematic review.

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Current surgical treatment of intermediate risk differentiated thyroid cancer: a systematic review.

Expert Rev Anticancer Ther. 2020 Nov 11;:

Authors: Guo MY, Wiseman JJ, Wiseman SM

Abstract
Introduction: Surgical treatment of thyroid cancer has become less aggressive but for many patients, the threshold for performing total thyroidectomy (TT), as opposed to thyroid lobectomy (TL), has remained unclear. Current American Thyroid Association (ATA) guidelines encourage more individualization of treatment options, which necessitates explicit review of the pros and cons of the different options with patients. Areas covered: This review focuses on the extent of surgery for treatment of intermediate-risk differentiated thyroid cancer, restricted to relevant literature available after publication of the 2015 ATA guidelines. Expert opinion: Dynamic risk-stratification facilitates a tailored approach when deciding on the extent of surgery for thyroid cancer. Treatment with TT allows for a lower recurrence risk, a simpler follow-up regimen, and treatment with adjuvant post-operative radioactive iodine. Treatment with TL has a lower associated risk of complications and avoid ance of lifelong thyroid hormone replacement but has a significant risk of requiring a completion thyroid lobectomy (CT). Overall, treatment with TL and TT have comparable survival outcomes, but TL is the more cost-effective option. Larger cancer size is correlated with worse clinical outcomes, and numerous subgroup analyses have shown poorer outcomes for cancers with a diameter that is 2-4 cm compared to 1-2cm.

PMID: 33176520 [PubMed - as supplied by publisher]

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