Cardiac metastasis in a living patient with oral cancer.

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Cardiac metastasis in a living patient with oral cancer.

Auris Nasus Larynx. 2018 Nov 20;:

Authors: Fujio H, Otsuki N, Horichi Y, Yanagisawa S, Nishio M, Teshima M, Shinomiya H, Hashikawa K, Nibu KI

Abstract
Cardiac metastasis from head and neck cancers are very rare. Metastases to heart are mostly diagnosed at autopsy, and seldom found while patients are alive. Patients with cardiac metastasis do not present with specific symptoms in the early stages, and diagnosis is often delayed until the disease has advanced significantly. Here, we report a 66-year-old lady who was diagnosed with cardiac metastasis 10 months after surgical resection of oral cancer. She died one month following the discovery of cardiac metastasis. Cardiac metastasis should be considered when unexplained and progressive decline of general health is observed, even in the absence of abnormalities on the electrocardiogram. Early diagnosis may be made by analyzing the chronological changes in the cardiac accumulation of fluorodeoxyglucose during positron emission tomography-computed tomography scan.

PMID: 30470634 [PubMed - as supplied by publisher]

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Surgical deroofing in the treatment of patients with auricular pseudocyst.

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Surgical deroofing in the treatment of patients with auricular pseudocyst.

Auris Nasus Larynx. 2018 Nov 20;:

Authors: Lee YJ, Kwon JG, Han HH

Abstract
OBJECTIVE: An auricular pseudocyst is a fluid filled cavity, characterized by a lack of epithelium, in the intra-cartilaginous space. Clinically, it presents as a painless lump on the upper anterior surface of the ear. Various treatment methods have been discussed in the literature, including aspiration, incision and drainage, or steroid injection. However, these approaches are associated with a high rate of recurrence and results are often esthetically unsatisfactory; therefore, a need for improved treatment approaches remains.
METHODS: From March, 2015, to June, 2017, 15 patients with auricular pseudocyst were treated with surgical deroofing followed by local contour pressure dressing with a simple bolster. In addition, the structure of the auricular pseudocyst was assessed at a microscopic level.
RESULTS: Patients were followed up for a mean period of 12 months, during which time there were no reports of postoperative complications or recurrence. The results were cosmetically excellent in all patients and no cartilage deformity was seen. Considering the composition of pseudocysts seen on microscopic evaluation, deroofing to remove the anterior leaflet and removal of debris from the posterior leaflet is an appropriate treatment modality.
CONCLUSION: This reliable and simple approach may be recommended as first line treatment for auricular pseudocysts to avoid recurrence and complications associated with other treatment modalities, such as cartilage deformity, skin depigmentation, and scarring.

PMID: 30470633 [PubMed - as supplied by publisher]

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How Much Loading Does Water Resistance Voice Therapy Impose on the Vocal Folds? An Experimental Human Study.

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How Much Loading Does Water Resistance Voice Therapy Impose on the Vocal Folds? An Experimental Human Study.

J Voice. 2018 Nov 20;:

Authors: Laukkanen AM, Geneid A, Bula V, Radolf V, Horáček J, Ikävalko T, Kukkonen T, Kankare E, Tyrmi J

Abstract
OBJECTIVES: Water resistance voice therapy applies phonation into water through a tube. This study investigates how strenuous this therapy can be for the vocal folds in terms of impact stress (IS). It further examines whether it is possible to estimate the IS using the contact quotient (CQ) and maximum derivative from an electroglottogram (EGG).
STUDY DESIGN: Experimental study.
METHODS: A male participant sustained a rounded back vowel [u:] or [o:] at a comfortable speaking pitch and loudness, and phonated into a silicone "Lax Vox" tube submerged 2 cm in water. High-speed videolaryngoscopy was performed with a rigid scope. Oral air pressure (Poral) was registered in a mouthpiece through which an endoscope was inserted into the larynx. An EGG was recorded.
RESULTS: The CQEGG from the EGG and the closed quotient from the glottal width (CQarea) increased, while the maximum glottal amplitude and absolute value of derivative minimum (dmin) and also the derivative maximum from the EGG decreased for phonation into water. Normalized amplitude quotient from the glottal width variation also decreased but the change was not significant.
CONCLUSIONS: Based on the glottal area findings, water resistance therapy does not seem to increase vocal fold loading (in terms of increased IS) even if the increase of CQarea, and CQEGG suggest so. CQEGG may qualitatively correspond to that of area, but the reliability of CQ (from the glottal area or the EGG) and the maximum derivative from the EGG as estimates of IS in semiocclusion exercises warrant further studies.

PMID: 30470593 [PubMed - as supplied by publisher]

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Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies.

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Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies.

Int J Environ Res Public Health. 2018 Nov 21;15(11):

Authors: Kim HB, Shim JY, Park B, Lee YJ

Abstract
The aim of this study was to examine the relationship between main air pollutants and all cancer mortality by performing a meta-analysis. We searched PubMed, EMBASE (a biomedical and pharmacological bibliographic database of published literature produced by Elsevier), and the reference lists of other reviews until April 2018. A random-effects model was employed to analyze the meta-estimates of each pollutant. A total of 30 cohort studies were included in the final analysis. Overall risk estimates of cancer mortality for 10 µg/m³ per increase of particulate matter (PM)2.5, PM10, and NO₂ were 1.17 (95% confidence interval (CI): 1.11⁻1.24), 1.09 (95% CI: 1.04⁻1.14), and 1.06 (95% CI: 1.02⁻1.10), respectively. With respect to the type of cancer, significant hazardous influences of PM2.5 were noticed for lung cancer mortality and non-lung cancer mortality including liver cancer, colorectal cancer, bladder cancer, and kidney cancer, respectively, while PM10 had harmful effects on mortality from lung cancer, pancreas cancer, and larynx cancer. Our meta-analysis of cohort studies indicates that exposure to the main air pollutants is associated with increased mortality from all cancers.

PMID: 30469439 [PubMed - in process]

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Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing.

Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing.

J Allergy Clin Immunol. 2018 Nov 21;:

Authors: Matsuda A, Asada Y, Suita N, Iwamoto S, Hirakata T, Yokoi N, Ohkawa Y, Okada Y, Yokomizo T, Ebihara N

Abstract
We found upregulation of 47 immunoglobulin genes and 22 S. aureus infection-related genes in refractory atopic keratoconjunctivitis tissue by RNA-seq analysis, suggesting that lymphoid neogenesis and stimuli from infection are essential components of the disorder.

PMID: 30471305 [PubMed - as supplied by publisher]

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Vaccination of non-allergic individuals with recombinant hypoallergenic fragments of birch pollen allergen Bet v 1: Safety, effects and mechanisms.

Vaccination of non-allergic individuals with recombinant hypoallergenic fragments of birch pollen allergen Bet v 1: Safety, effects and mechanisms.

J Allergy Clin Immunol. 2018 Nov 21;:

Authors: Campana R, Marth K, Zieglmayer P, Weber M, Lupinek C, Zhernov Y, Elisyutina O, Khaitov M, Rigler E, Westritschnig K, Berger U, Wolkersdorfer M, Horak F, Horak F, Valenta R

Abstract
This is the first double-blind, placebo-controlled study showing that vaccination with recombinant hypoallergenic allergen-derivatives is safe and induces sustained allergen-specific IgG responses which block allergic patients IgE binding to the allergen.

PMID: 30471304 [PubMed - as supplied by publisher]

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IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice.

IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice.

J Allergy Clin Immunol. 2018 Nov 21;:

Authors: Morita H, Tamari M, Fujiwara M, Motomura K, Koezuka Y, Ichien G, Matsumoto K, Ishizaka K, Saito H

Abstract
Environmental events in early in life are critical to development of allergic diseases later in life. We found IgE-class-specific immunosuppression in offspring whose mothers had been administered anti-IgE during pregnancy.

PMID: 30471303 [PubMed - as supplied by publisher]

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