Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open-label randomized trial

alexandrossfakianakis shared this article with you from Inoreader Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open-label randomized trial via Trials - Latest Articles Women in Africa face disproportionate risk of human immunodeficiency virus (HIV) acquisition, accounting for more than half of new infections in Africa and similarly face a disproportionate burden of sexually ... View on Web

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Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial

alexandrossfakianakis shared this article with you from Inoreader Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial via Trials - Latest Articles Dizziness and vertigo affect around 15% of adults annually and represent common reasons for contacting health services, accounting for around 3% of all emergency department visits worldwide. Vertigo is also as... View on Web

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The role of bacterial corrosion on recolonization of titanium implant surfaces: An in vitro study

alexandrossfakianakis shared this article with you from Inoreader The role of bacterial corrosion on recolonization of titanium implant surfaces: An in vitro study via Clinical Implant Dentistry and Related Research Abstract Background Inflammation triggered by bacterial biofilms in the surrounding tissue is a major etiological factor for peri-implantitis and subsequent implant failure. However, little is known about the direct effects of bacterial corrosion and recolonization on implant failure Purpose To investigate the influence of oral commensals on bacterial corrosion and recolonization of titanium surfaces. Materials and Methods Streptococcus sanguinis (S. sanguinis) and Porphyromonas gingivalis (P. gingivalis), which are key bacteria in oral biofilm formation, were cultured on commercially pure titanium and titanium-aluminum-vanadium (Ti6Al4V) plates in artificial saliva/brain heart infusion medium under aerobic or anaerobic conditions. Biofilm formation was examined after 7 and 21 days by crystal violet and live/dead staining. Titanium ions released into culture supernatants were analyzed over a period of 21 days by atomic absorption spectrometry. Visual changes in surface morphology were investigated using scanning electron microscopy. Biofilm formation on sterilized, biocorroded, and recolonized implant surfaces was determined by crystal violet staining. Results S. sanguinis and P. gingivalis formed stable biofilms on the titanium samples. Bacterial corrosion led to a significant increase in titanium ion release from these titanium plates (p < 0.01), which was significantly higher under aerobic conditions on pure titanium (p ≤ 0.001). No obvious morphological surface changes, such as pitting and discoloration, were detected in the titanium samples. During early biofilm formation, the addition of titanium ions significantly decreased the number of live cells. In contrast, a significant effect on biofilm mass was only detected with P. gingivalis. Bacterial corrosion had no influence on bacterial recolonization following sterilization of titanium and Ti6Al4V surfaces. Conclusion Bacterial corrosion differs between oral commensal bacteria and leads to increased titanium ion release from titanium plates. The titanium ion release did not influence biofilm formation or bacterial recolonization under in vitro conditions View on Web

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Influence of the Residual Ridge Widths and Implant Thread Designs on Implant Positioning Using Static Implant Guided Surgery

alexandrossfakianakis shared this article with you from Inoreader Influence of the Residual Ridge Widths and Implant Thread Designs on Implant Positioning Using Static Implant Guided Surgery via Journal of Prosthodontics Abstract Purpose Aggressive implant macro thread designs have been widely used. However, the effects of the aggressive thread design on the accuracy of static guided surgery, especially in a case of narrow residual ridge, have not been well-studied. The aim of this study was to evaluate the effects of two different implant macro thread designs and the residual ridge widths on the accuracy of tooth-supported static guided implant surgery. Materials and Methods Forty implant fixtures with two different macro-designs: a conventional thread design bone level tapered (BLT), and an aggressive thread design bone level tapered (BLX) were placed in 40 simulated polyurethane models with narrow and wide residual ridges. The placed implant positions were compared with the planned implant position and angulational deviation, as well as three-dimensional deviations at the entry and apex of the implant were measured. One-way ANOVA with Tukey's multiple comparisons (ɑ = 0.05) were used to determine level of significance between the mean and variance deviation values. 95% confidence intervals and box plots were used to demonstrate the means and ranges of precision. Results In terms of angulational deviation, there was no statistically significant difference in the mean deviations for both types of implants, P = 1.55 and P = 0.84 for wide and narrow ridge groups, respectively. However, the range of deviation was much larger in the narrow ridge of the BLX group compared to the BLT group. In both narrow ridge and wide ridge, the BLX group had lower mean 3D deviation values at both the entry and the apex with statistically significant differences for both entry point of the wide ridge (P = 0.027) and narrow ridge (P = 0.022) as well as at the apex of the wide ridge (P = 0.006) but not the apex of the narrow ridge (P = 0.142) Conclusion The aggressive larger thread design of dental implants may influence the accuracy of implant placement more than the ridge dimension. This article is protected by copyright. All rights reserved View on Web

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HIV Drug Resistance in Persons Initiating or Re‐initiating First‐line Antiretroviral Therapy in Paraguay: Results of a National Patient Survey

alexandrossfakianakis shared this article with you from Inoreader HIV Drug Resistance in Persons Initiating or Re‐initiating First‐line Antiretroviral Therapy in Paraguay: Results of a National Patient Survey via Journal of Medical Virology ABSTRACT Background HIV drug resistance increases mortality and morbidity and antiretroviral therapy (ART) costs. We describe Paraguay's first nationally representative survey on pretreatment drug resistance (PDR) conducted among persons who initiated or re-initiated ART in 2019. Material and Methods We conducted a cross-sectional survey of antiretroviral drug resistance in Paraguay during 2019. Participants were sampled at four comprehensive care clinics where 90% of patients with HIV in Paraguay initiate ART. Patients included were adults ≥18 years old who initiated first-line ART or re-initiated the same first-line ART regimen after ≥3 months of discontinuation. Results Of 208 patients, 93.8% had no prior ART exposure, 3.8% re-initiated the same regimen, 2.4% had unknown prior ART exposure; 31.3% had a CD4 count <200 cells/µL. Mutations associated with resistance were present in 15.4% of patients. Mutations associated with resistance to non-nu cleoside reverse transcriptase inhibitors (NNRTI) were present in 13.0% of patients, nucleoside reverse transcriptase inhibitors in 4.3%, and integrase inhibitors in 3.4%. Mutations associated with resistance to tenofovir were present in 1.0% of patients and emtricitabine/lamivudine in 1.4%. Conclusions Nearly one in six patients had PDR in Paraguay's first nationally representative sample. High NNRTI PDR prevalence underscores the need to accelerate the transition to dolutegravir-based first-line ART. Low PDR prevalence to tenofovir and emtricitabine is reassuring as these antiretrovirals are part of the WHO-recommended oral pre-exposure prophylaxis (PrEP) regimen. The high proportion of individuals initiating ART at a late disease stage highlights the need to improve treatment linkage strategies and implement WHO rapid ART initiation recommendations. This article is protected by copyright. All rights reserved. View on Web

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Correlation between lifestyles of tobacco smoking and alcohol drinking, and expression of p53 and GLUT1 in synchronous oral squamous cell carcinoma with colorectal cancer

alexandrossfakianakis shared this article with you from Inoreader Correlation between lifestyles of tobacco smoking and alcohol drinking, and expression of p53 and GLUT1 in synchronous oral squamous cell carcinoma with colorectal cancer via ScienceDirect Publication: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Publication date: Available online 14 June 2022 Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Fumitaka Asahara, Masae Yamazaki, Katsutoshi Kokubun, Kenichi Matsuzaka, Hiroshi Kishikawa, Junichi Matsui, Takeshi Nomura View on Web

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Giant solitary synovial osteochondromatosis of the temporomandibular joint: A case report

alexandrossfakianakis shared this article with you from Inoreader Giant solitary synovial osteochondromatosis of the temporomandibular joint: A case report via ScienceDirect Publication: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Publication date: Available online 15 June 2022 Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Hisashi Ozaki, Masatoshi Chiba, Yoshioki Hamamoto, Mitsuyoshi Iino View on Web

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