Biologic Agents in Plastic Surgery

alexandrossfakianakis shared this article with you from Inoreader Biologic Agents in Plastic Surgery via Seminars in Plastic Surgery Semin Plast Surg 2022; 36: 002-002 DOI: 10.1055/s-0042-1743454 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA Article in Thieme eJournals: Table of contents  |  Full text View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Efficacy of dexmedetomidine on postoperative pain in patients undergoing gastric and esophageal endoscopic submucosal dissection: a study protocol for a randomized controlled prospective trial

alexandrossfakianakis shared this article with you from Inoreader Efficacy of dexmedetomidine on postoperative pain in patients undergoing gastric and esophageal endoscopic submucosal dissection: a study protocol for a randomized controlled prospective trial via Trials - Latest Articles Endoscopic submucosal dissection (ESD) is widely used as an effective treatment of early gastric and esophageal tumors, as it is minimally invasive, safe, and convenient. Epigastric pain is a common complicati... View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Benchmarking Feature Selection Methods in Radiomics

alexandrossfakianakis shared this article with you from Inoreader Benchmarking Feature Selection Methods in Radiomics via Investigative Radiology - Current Issue Objectives A critical problem in radiomic studies is the high dimensionality of the datasets, which stems from small sample sizes and many generic features extracted from the volume of interest. Therefore, feature selection methods are used, which aim to remove redundant as well as irrelevant features. Because there are many feature selection algorithms, it is key to understand their performance in the context of radiomics. Materials and Methods A total of 29 feature selection algorithms and 10 classifiers were evaluated on 10 publicly available radiomic datasets. Feature selection methods were compared for training times, for the stability of the selected features, and for ranking, which measures the pairwise similarity of the methods. In addition, the predictive performance of the algorithms was measured by utilizing the area under the receiver operating characteristic curve of the best-performing classifier. Results Feature selections differed largely in training times as well as stability and similarity. No single method was able to outperform another one consistently in predictive performance. Conclusion Our results indicated that simpler methods are more stable than complex ones and do not perform worse in terms of area under the receiver operating characteristic curve. Analysis of variance, least absolute shrinkage and selection operator, and minimum redundancy, maximum relevance ensemble appear to be good choices for radiomic studies in terms of predictive performance, as they outperformed most other feature selection methods. View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Homoarginine Treatment of Rats Improves Cardiac Function and Remodeling in Response to Pressure Overload

alexandrossfakianakis shared this article with you from Inoreader Homoarginine Treatment of Rats Improves Cardiac Function and Remodeling in Response to Pressure Overload via Fundamental & Clinical Pharmacology Abstract Background Low serum concentrations of the amino acid homoarginine (HA) are associated with increased cardiovascular mortality by incompletely understood mechanisms. Objectives This study sought to assess the influence of HA on cardiac remodeling in rats undergoing either transaortic banding or inhibition of nitric oxide synthesis by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME). Methods Male Wistar rats (n=136) underwent a sham operation (SH) or aortic banding (AB). Both groups were equally divided into fourteen subgroups, receiving different doses of HA alone or in combination with lisinopril, spironolactone, or L-NAME over 4 weeks. Results HA treatment in AB animals resulted in a dose-dependent improvement of cardiac function up to a concentration of 800 mg·kg-1·day-1. Combining 800 mg·kg-1·day-1 HA with spironolactone or lisinopril yielded additional effects, showing a positive correlation with LV ejection fraction (+33%, p=0.0002) and fractional shortening (+41%, p=0.0014). An inverse association was observed with collagen area fraction (-41%, p<0.0001), myocyte cross-sectional area (-22%, p<0.0001) and the molecular markers atrial natriuretic factor (-74%, p=0.0091), brain natriuretic peptide (-42%, p=0.0298), beta-myosin heavy chain (-46%, p=0.0411), and collagen type V alpha 1 chain (-73%, p=0.0257) compared to placebo-treated AB animals. Co-administration of HA and L-NAME was found to attenuate cardiac remodeling and prevent NO-deficient hypertension following AB. Conclusion HA treatment has led to a dose-dependent improvement of myocardial function and marked histological and molecular changes in cardiac remodeling following AB. Combining HA with standard heart failure medication resulted in additional beneficial effects boosting its direct impact on heart failure pathophysiology. View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation

alexandrossfakianakis shared this article with you from Inoreader Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation via ScienceDirect Publication: Experimental Cell Research Publication date: Available online 10 June 2022 Source: Experimental Cell Research Author(s): Sho Takahashi, Shusaku Shibutani, Hiroyuki Iwata View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Evaluation of clotrimazole prophylaxis on tacrolimus trough concentrations in kidney transplant recipients

alexandrossfakianakis shared this article with you from Inoreader Evaluation of clotrimazole prophylaxis on tacrolimus trough concentrations in kidney transplant recipients via Transplant Infectious Disease Abstract Background Clotrimazole troches are used as prophylaxis against oropharyngeal candidiasis post-transplant and have limited systemic absorption. Following several occurrences of tacrolimus concentration fluctuations after clotrimazole discontinuation, its use as prophylaxis was discontinued post-kidney transplant. Methods We conducted a retrospective cohort study to evaluate the effect of clotrimazole prophylaxis on tacrolimus trough concentrations post-kidney transplant. The study included adult patients who received a kidney transplant at Cleveland Clinic Main Campus from August 1, 2019 to July 1, 2020 and were maintained on per-protocol, standard-dose tacrolimus through 90 days post-transplant. Patients were excluded if they received cyclosporine, systemic antifungals, strong CYP3A4 inhibitors or inducers, or a simultaneous multiorgan transplant. The primary objective was to compare tacrolimus trough concentrations before and after completion of clotrimazole prophylaxis. Secondary objectives were to compare the time to first post-transplant goal tacrolimus trough concentration, the rate of for-cause allograft biopsies within 90 days after transplant, and the incidence and type of candidiasis within 30 days after transplant, pre- and post- protocol change. Results Following clotrimazole discontinuation, the median tacrolimus trough concentration decreased from 10.5 ng/mL (IQR 8.4-12.2) to 6.6 ng/mL (IQR 5–8.7, p<0.0001). No statistically significant differences in the rate of for-cause allograft biopsies (4.9% vs. 9.7%, p = 0.264) or incidence of candidiasis (1.2% vs. 5.4%, p = 0.217) were observed between those who received clotrimazole and those who did not receive clotrimazole. Conclusions Our study provides further evidence of a significant drug-drug interaction between tacrolimus and clotrimazole among kidney transplant recipients that can potentially lead to negative allograft outcomes. This article is protected by copyright. All rights reserved View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial

alexandrossfakianakis shared this article with you from Inoreader Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial via Trials - Latest Articles Diabetes mellitus (DM) increases the risk of tuberculosis (TB) and will hamper global TB control due to the dramatic rise in type 2 DM in TB-endemic settings. In this trial, we will examine the efficacy and sa... View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.