Bone Scan With SPECT/CT Demonstrated C1 to C2 Involvement in Rheumatic Arthritis

alexandrossfakianakis shared this article with you from Inoreader Bone Scan With SPECT/CT Demonstrated C1 to C2 Involvement in Rheumatic Arthritis Via Clinical Nuclear Medicine - Published Ahead-of-Print An 80-year-old man was treated with rituximab for active rheumatoid arthritis until 2019, now controlled with Salazopyrin, prednisolone, methotrexate, and folic acid. However, laboratory data showed elevated C-reactive protein and erythrocyte sedimentation rate. Whole-body bone scan showed bony and joint destruction to the upper cervical vertebra (C spine), bilateral shoulders, wrists, finger joints, ankles, and left knee. SPECT/CT localized the upper C spine uptake to the C1/C2 joint and adjacent C1 and C2 with C1/C2 subluxation. C spine CT showed vertical atlantoaxial subluxation and bony erosions. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PET/CT Imaging of Hemorrhagic Pseudotumor Arising From Treated Plasmacytoma

alexandrossfakianakis shared this article with you from Inoreader PET/CT Imaging of Hemorrhagic Pseudotumor Arising From Treated Plasmacytoma Via Clinical Nuclear Medicine - Published Ahead-of-Print Hemorrhagic pseudotumor occurs in approximately 1% to 2% of patients with hemophilia. This lesion is exceptionally rare in nonhemophiliac individuals. The authors present a case of treated right ischial plasmacytoma with a progressively enlarging expansile hemorrhagic pseudotumor, documented on 18F-FDG PET/CT and MRI and confirmed by histology. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nivolumab Immunotherapy–Related Skin Reactions Detected on 18F-FDG PET/CT in Renal Cell Cancer

alexandrossfakianakis shared this article with you from Inoreader Nivolumab Immunotherapy–Related Skin Reactions Detected on 18F-FDG PET/CT in Renal Cell Cancer Via Clinical Nuclear Medicine - Published Ahead-of-Print Nivolumab, a fully human immunoglobulin G4 anti–programmed cell death 1 antibody, provides a novel therapy option for patients with metastatic cancers. Immunotherapy agents have been associated with immune-related adverse events (irAEs), which may be detected on 18F-FDG PET/CT. Cutaneous toxicities are one of the most common irAEs in the form of maculopapular rash (eczema-like spongiotic dermatitis) and pruritus. These irAEs may lead to false-positive findings on PET/CT done during the treatment. One should be aware of the potential irAEs while interpreting PET/CT to avoid misinterpretation. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Glioblastoma Recurrence Versus Radiotherapy Injury: Combined Model of Diffusion Kurtosis Imaging and: 11: C-MET Using PET/MRI May Increase Accuracy of Differentiation

alexandrossfakianakis shared this article with you from Inoreader Glioblastoma Recurrence Versus Radiotherapy Injury: Combined Model of Diffusion Kurtosis Imaging and: 11: C-MET Using PET/MRI May Increase Accuracy of Differentiation Via Clinical Nuclear Medicine - Published Ahead-of-Print Purpose To evaluate the diagnostic potential of decision-tree model of diffusion kurtosis imaging (DKI) and 11C-methionine (11C-MET) PET, for the differentiation of radiotherapy (RT) injury from glioblastoma recurrence. Methods Eighty-six glioblastoma cases with suspected lesions after RT were retrospectively enrolled. Based on histopathology or follow-up, 48 patients were diagnosed with local glioblastoma recurrence, and 38 patients had RT injury between April 2014 and December 2019. All the patients underwent PET/MRI examinations. Multiple parameters were derived based on the ratio of tumor to normal control (TNR), including SUVmax and SUVmean, mean value of kurtosis and diffusivity (MK, MD) from DKI, and histogram parameters. The diagnostic models were established by decision trees. Receiver operating characteristic analysis was used for evaluating the diagnostic accuracy of each independent parameter and all the diagnostic models. Results The intercluster correlations of DKI, PET, and texture parameters were relatively weak, whereas the intracluster correlations were strong. Compared with models of DKI alone (sensitivity =1.00, specificity = 0.70, area under the curve [AUC] = 0.85) and PET alone (sensitivity = 0.83, specificity = 0.90, AUC = 0.89), the combined model demonstrated the best diagnostic accuracy (sensitivity = 1.00, specificity = 0.90, AUC = 0.95). Conclusions Diffusion kurtosis imaging, 11C-MET PET, and histogram parameters provide complementary information about tissue. The decision-tree model combined with these parameters has the potential to further increase diagnostic accuracy for the discrimination between RT injury and glioblastoma recurrence over the standard Response Assessment in Neuro-Oncology criteria. 11C-MET PET/MRI may thus contribute to the management of glioblastoma patients with suspected lesions after RT. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Neonatal Intensive Care Workflow Analysis Informing NEC-Zero Clinical Decision Support Design

alexandrossfakianakis shared this article with you from Inoreader Neonatal Intensive Care Workflow Analysis Informing NEC-Zero Clinical Decision Support Design Via Computers Informatics Nursing - Published Ahead-of-Print Decision support in neonatal ICUs is needed, especially for prevention and risk awareness of the devastating complication of necrotizing enterocolitis, a major cause of emergency surgery among fragile infants. The purpose of this study was to describe the current clinical workflow and sociotechnical processes among clinicians for necrotizing enterocolitis risk awareness, timely recognition of symptoms, and treatment to inform decision support design. A qualitative descriptive study was conducted. Focus groups were held in two neonatal ICUs (five groups in Unit A and six in Unit B). Transcripts were analyzed using content analys is and compared with field notes. Clinicians (N = 27) included nurses (37%), physicians (30%), neonatal nurse practitioners (19%), and other staff (16%). Workflow processes differed for nurses (who see necrotizing enterocolitis signs and notify providers to order diagnostic tests and treatments) and providers (who receive notification of necrotizing enterocolitis concern and then decide how to act). Clinicians desired (1) a necrotizing enterocolitis-relevant dashboard to support nutrition tracking and necrotizing enterocolitis recognition; (2) features to support decision-making (eg, necrotizing enterocolitis risk and adherence scoring); (3) breast milk tracking and feeding clinical decision support; (4) tools for necrotizing enterocolitis surveillance and quality reporting; and (5) general EHR optimizations to improve user experience. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of brachial–ankle pulse wave velocity and carotid–femoral pulse wave velocity in association with albuminuria in a community of Beijing: a cross-sectional study

alexandrossfakianakis shared this article with you from Inoreader Comparison of brachial–ankle pulse wave velocity and carotid–femoral pulse wave velocity in association with albuminuria in a community of Beijing: a cross-sectional study Via Journal of Human Hypertension - Issue - nature.com science feeds Journal of Human Hypertension, Published online: 26 April 2022; doi:10.1038/s41371-022-00697-7 Comparison of brachial–ankle pulse wave velocity and carotid–femoral pulse wave velocity in association with albuminuria in a community of Beijing: a cross-sectional study View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Decitabine increases neoantigen and cancer testis antigen expression to enhance T cell-mediated toxicity against glioblastoma

alexandrossfakianakis shared this article with you from Inoreader Decitabine increases neoantigen and cancer testis antigen expression to enhance T cell-mediated toxicity against glioblastoma Via Neuro-Oncology Advance Access Abstract Background Glioblastoma (GBM) is the most common and malignant primary brain tumour in adults. Despite maximal treatment, median survival remains dismal at 14-24 months. Immunotherapies, such as checkpoint inhibition, have revolutionised management of some cancers but have little benefit for GBM patients. This is, in part, due to the low mutational and neoantigen burden in this immunogenically 'cold' tumour. Methods U87MG and patient derived cell lines were treated with 5-aza-2'-deoxycytidine (DAC) and underwent whole exome and transcriptome sequencing. Cell lines were then subjected to cellular assays with neoantigen and cancer testis antigen (CTA) specific T cells. Results We demonstrate that DAC increases neoantigen and CTA mRNA expression through DNA hypomethylation. This results in increased neoantigen presentation by MHC class I in tumour cells, leading to increased neoantigen- and CTA-specific T cell activat ion and killing of DAC-treated cancer cells. In addition, we show that patients have endogenous cancer-specific T cells in both tumour and blood, which show increased tumour-specific activation in the presence of DAC-treated cells. Conclusions Our work shows that DAC increases GBM immunogenicity and consequent susceptibility to T cell responses in-vitro. Our results support a potential use of DAC as a sensitizing agent to immunotherapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.