Needle Fracture During Injection Medialization Laryngoplasty

xlomafota13 shared this article with you from Inoreader Needle Fracture During Injection Medialization Laryngoplasty Via Journal of Voice Awake injection medialization laryngoplasty is one of the most common therapeutic procedures done by laryngologists in the office or at the bedside. Complications of injection needle fracture are rarely reported. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross‐Over Observational Study

xlomafota13 shared this article with you from Inoreader Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross‐Over Observational Study Via The Laryngoscope Objectives/Hypothesis To investigate the efficacy of low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet as single treatment for patients with laryngopharyngeal reflux (LPR). Study Design Cross-over observational study. Methods Patients with LPR diagnosis at the hypopharyngeal-esophageal multichannel intraluminal impedance-pH-monitoring were prospectively recruited from the reflux clinic of three University Hospitals. Patients were instructed to follow low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet for 6 to 12 weeks. Pre- to post-treatment symptom and finding changes were evaluated with reflux symptom score (RSS) and reflux sign assessment. Findings were compared to those of a control period where patients did not receive any treatment or diet. Diet was evaluated with refluxogenic diet score (REDS). Results Fifty patients completed the study (19 males). Otolaryngological, digestive, and total RSS scores significantly improved from baseline to 6-week post-diet, while there were no significant changes during the control period. At 6-week post-diet, 37 (74%) patients reported significant symptom improvement or relief. Among them, symptoms continued to improve from 6 to 12 weeks in 27 cases, corresponding to a diet success rate of 54%. The REDS was predictive of the baseline RSS (P = .031). Conclusion Low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet is an alternative cost-effective therapeutic approach for patients with LPR. Patients with higher REDS reported higher baseline symptom score. Level of Evidence 3 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of Slide Tracheoplasty Technique on Postoperative Anatomic Outcomes in Three‐Dimensional Printed Models

xlomafota13 shared this article with you from Inoreader Comparison of Slide Tracheoplasty Technique on Postoperative Anatomic Outcomes in Three‐Dimensional Printed Models Via The Laryngoscope Objectives/Hypothesis We hypothesized that the use of three-dimensional (3D) printed tracheal models to reproducibly simulate surgical technique variations in slide tracheoplasty would demonstrate the quantitative impact of surgical variables on postoperative tracheal dimensions. Study Design Prospective analysis of three-dimensional printed surgical simulation models. Methods Slide tracheoplasty was performed on 3D printed long segment tracheal stenosis models with combinations of tracheal transection incision angle (90°, 45° beveled superior to inferior, 45° beveled inferior to superior) and tracheal transection location relative to the stenosis (at midpoint, 2 mm each superior and inferior to midpoint). Postoperative computed tomography (CT) scans measured changes in tracheal length, volume, and cross-sectional area compared to controls. Statistical analysis was performed using one-way analysis of variance and unpaired two-tailed t-tests. Results Slide tracheoplasty yielded 27 reconstructed tracheas. On average, slide tracheoplasty reduced total tracheal length by 36%. Beveled tracheal incisions yielded 9.5% longer final tracheas than straight transection incisions (P < .0001). Cross-sectional area at the stenosis midpoint increased from 9.0 mm2 to 45 mm2 but did not vary with technique (P > .05). Total tracheal luminal volume increased from 900 mm3 to 1378 mm3 overall and was largest with beveled incisions (P = .03). More material was discarded with straight incisions compared to beveled (89 mg vs. 19 mg, P < .0001). Conclusions Beveled tracheal transection incisions resulted in increased tracheal length, longer anastomotic segments, increased volume, and reduced tissue waste as compared to straight incisions. Offsetting the incision from the midpoint of stenosis did not significantly affect reconstructed tracheal morphology. Using 3D printed models for surgical simulation can be helpful for the quantitative study of the effect isolated surgical variables on technical outcomes. Level of Evidence 3 Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Medical Management for Eustachian Tube Dysfunction in Adults: A Systematic Review and Meta‐Analysis

xlomafota13 shared this article with you from Inoreader Medical Management for Eustachian Tube Dysfunction in Adults: A Systematic Review and Meta‐Analysis Via The Laryngoscope Objective Medical treatment for eustachian tube dysfunction (ETD) is varied, with physician preference driving treatment choice and limited guidance for these options. An evaluation of the efficacy of medical management (MM) for ETD is warranted. Methods A systematic review of three databases (PubMed, Scopus, and Embase) was performed through December 2020. Adults treated nonsurgically for ETD were included. Exclusion criteria were as follows: patulous ETD, ETD deriving from craniofacial anomalies, or surgical treatment. Data were extracted independently by two reviewers according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A meta-analysis of continuous measures, proportions, and risk ratio was conducted. Results Twelve articles were identified by systematic review, with either level 2 or 3 evidence. A meta-analysis of available data was performed on nine studies. A pooled cohort found 50.3% (95% confidence interval [CI], 41.7–59.0) of patients experienced symptomatic improvement with MM. ETDQ-7 scores improved in a clinically nonsignificant manner by −0.88 (95% CI, −1.12 to −0.64) following medical treatment. Further, MM benefited from subacute and chronic symptoms in 30% to 64% and 11% to 50% of cases, respectively. Intranasal corticosteroids (INCS) were not efficacious, improving only 11% to 18% of chronic cases. Therapies such as Politzer devices and Valsalva therapy had minimally beneficial results. Conclusion Our review did not find any level 1 evidence for MM of ETD in adults. Available evidence indicates INCS are ineffective for chronic symptoms and the efficacy of nonsurgical options for subacute ETD has yet to be determined. Further randomized controlled trials are needed to discern efficacy of single-agent medical therapies. Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nusinersen by subcutaneous intrathecal catheter for symptomatic spinal muscular atrophy patients with complex spine anatomy

xlomafota13 shared this article with you from Inoreader Nusinersen by subcutaneous intrathecal catheter for symptomatic spinal muscular atrophy patients with complex spine anatomy Via leak of cerebrospinal fluid Muscle Nerve. 2021 Oct 4. doi: 10.1002/mus.27425. Online ahead of print. ABSTRACT INTRODUCTION/AIMS: Intrathecal administration of nusinersen is challenging in patients with spinal muscular atrophy (SMA) who have spine deformities or fusions. We prospectively studied the safety and efficacy of nusinersen administration via an indwelling subcutaneous intrathecal catheter (SIC) for SMA patients with advanced disease. METHODS: Seventeen participants commenced nusinersen therapy between 2.7 and 31.5 years of age and received 9-12 doses via SIC. Safety was assessed in all participants. A separate efficacy analysis comprised 11 non-ambulatory, treatment-naïve SMA patients (18.1 ± 6.8 years) with three SMN2 copies and complex spine anatomy. RESULTS: In the safety analysis, 14 treatment-related adverse events (AEs) occurred among 12 (71%) participants; all were related to the SIC and not nusinersen. Device-related AEs interfered with 2. 5% of nusinersen doses. Four SICs (24%) required surgical revision due to mechanical malfunction with or without cerebrospinal fluid leak (n = 2), and one (6%) was removed due to Staphylococcus epidermidis meningitis. In the efficacy analysis, mean performance on the Nine Hole Peg Test improved in dominant (15.9%, p = 0.0.012) and non-dominant (19.0%, p = 0.008) hands and grip strength increased 44.9% (p = 0.0.031). We observed no significant changes in motor scales, muscle force, pulmonary function, or SMA biomarkers. All participants in the efficacy cohort reported one or more subjective improvements of endurance, purposeful hand use, arm strength, head control, and/or speech. DISCUSSION: For SMA patients with complex spine anatomy, the SIC allows for reliable outpatient administration of nusinersen that results in meaningful improvements of upper limb function, but introduces risks of technical malfunction and iatrogenic infection. This article is protected by copyright. Al l rights reserved. PMID:34606118 | DOI:10.1002/mus.27425 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Application of carbon dots and their composite materials for the detection and removal of radioactive ions: A review

xlomafota13 shared this article with you from Inoreader Application of carbon dots and their composite materials for the detection and removal of radioactive ions: A review Via radioactive iodine Chemosphere. 2021 Sep 27:132313. doi: 10.1016/j.chemosphere.2021.132313. Online ahead of print. ABSTRACT Radioactive ions with high-heat release or long half-life could cause long-term influence on environment and they might enter the food chain to damage human body for their toxicity and radioactivity. It is of great importance to develop methods and materials to detect and remove radioactive ions. Carbon dots and their composite materials has been applied widely in many fields due to their plentiful raw materials, facile synthesis and functional process, unique optical property and abundant functional groups. This comprehensive review focuses on the preparation of CDs and composite materials for the detection and adsorption of radioactive ions. Firstly, the recent-developed synthetic methods for CDs were summarized briefly, including hydrothermal/solvothermal, microwave, electrochemistry, microplasma, chemical oxidation methods, focusing on the influence of CDs properties. Secondly, the synthetic methods for CDs composite materials were classified to four categories and summarized generally. Thirdly, the application of CDs for radioactive ions detection and adsorption were explored and concluded including uranium, iodine, europium, strontium, samarium et al. Finally, the detection and adsorption mechanism for radioactive ions were searched and the perspective and outlook of CDs for detection and adsorption radioactive ions have been proposed based on our und erstanding. PMID:34592206 | DOI:10.1016/j.chemosphere.2021.132313 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Osteoblasts-derived exosomes regulate osteoclast differentiation through miR-503-3p/Hpse axis

xlomafota13 shared this article with you from Inoreader Osteoblasts-derived exosomes regulate osteoclast differentiation through miR-503-3p/Hpse axis Via histochem Acta Histochem. 2021 Sep 27;123(7):151790. doi: 10.1016/j.acthis.2021.151790. Online ahead of print. ABSTRACT MicroRNAs (miRNAs) are involved in bone remodeling by regulating the balance of bone formation and resorption. Increasing evidence has confirmed that the communication between osteoclast and osteoblast through secreting exosomes and transferring miRNAs. It has been reported that mineralized osteoblasts release exosomes containing more miR-503-3p. However, the roles a nd molecular mechanisms of osteoblast exosomes-derived miR-503-3p in osteoclast differentiation remain elusive. Here, we isolated exosomes from the supernatant of osteoblasts and identified the exosome characterization through transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blot assay. In addition, we found that exosomes and miR-503-3p secreted by osteoblasts inhibited the differentiation of osteoclast progenitor cells. Meanwhile, we found that Hpse (heparanase gene) was a target gene of miR-503-3p and miR-503-3p inhibited the osteoclast differentiation through downregulating the expression of Hpse. In summary, our results demonstrated the roles and the mechanism of osteoblast-derived exosomes inhibited the osteoclast differentiation via miR-503-3p/Hpse axis. PMID:34592492 | DOI:10.1016/j.acthis.2021.151790 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.