Blog Archive

Αλέξανδρος Γ. Σφακιανάκης

Thursday, January 28, 2021

Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival

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Publication date: Available online 28 January 2021

Source: American Journal of Otolaryngology

Author(s): Avigeet Gupta, Joshua A. Lee, Shaun A. Nguyen, Eric J. Lentsch

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Why Clinicians Choose Their Language Intervention Approach: An International Perspective on Intervention for Children with Developmental Language Disorder

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Purpose: Considerable progress has been made in recent years in generating external evidence underpinning interventions for children with developmental language disorder (DLD), but less is known about the practitioner decision-making process underpinning such interventions and whether such decisions are context specific or are internationally generalizable. Methods: An online survey about clinical practice was developed by members of COST Action IS1406, an EU-funde d research network, which included representation from 39 countries. The participants were 2,408 practitioners who answered questions in relation to their decision making for a specific child of their choosing with DLD. Analysis of open-ended questions was undertaken, and data were converted into codes for the purpose of quantitative analysis. Results: Although a wide range of intervention approaches and rationales were reported, the majority of responses referenced a client-centred approach. Level of functioning was used as a rationale only if a child had severe DLD. Practitioners with university level education or above were less likely to report basing intervention on client-centred factors. A number of differently named interventions with variable theoretical and empirical underpinnings were used in different countries. Conclusions: Specific client and practitioner characteristics have an impact on the intervention approaches and rationales adopted ac ross countries. A limited number of practitioners reported use of external scientific evidence, which suggests that there should be more initiatives in basic training of practitioners and continuing professional development to encourage the uptake of scientific evidence-based practice.
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Biomarkers in atopic dermatitis - a review on behalf of the international eczema council

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Atopic dermatitis (AD) is a common yet complex skin disease, posing a therapeutic challenge with increasingly recognized different phenotypes among variable patient populations. As therapeutic response may vary based on the heterogenous clinical and molecular phenotypes, a shift towards precision medicine approaches may improve AD management. Herein we will consider biomarkers as potential instruments in the toolbox of precision medicine in AD and will review the process of biomarker development and validation, the opinion of AD experts on the use of biomarkers, types of biomarkers, encompassing biomarkers that may improve AD diagnosis, biomarkers reflecting disease severity, and those potentially predicting AD development, concomitant atopic diseases or therapeutic response, and current practice of biomarkers in AD.
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Skin-resident natural killer T cells participate to cutaneous allergic inflammation in atopic dermatitis

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Skin-resident CXCR4+ NKT cells have a role in atopic dermatitis.
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Acute Laryngeal Injury After Intubation

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Although intubation is often necessary and lifesaving, there are known laryngotracheal consequences. Otolaryngologists are all too familiar with the vocal-fold damage and inflammatory conditions that are associated with prolonged intubation because patients often present in the hospital or clinic with dysphonia or dyspnea. The size of the endotracheal tube and the duration of intubation are known to be risk factors for postintubation damage. The pathophysiology is well understood to be caused by pressure-induced damage to the mucosal and car tilaginous structures of the larynx. However, despite this knowledge, laryngeal damage is often considered unavoidable, accrued as a result of a lifesaving stay in an intensive care unit. The resulting disease state can be so functionally devastating and difficult to treat that many otolaryngologists are left wondering: is there something we can do to prevent this from happening?
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Early Intervention for the Treatment of Acute Laryngeal Injury After Intubation

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This cohort study compares functional outcomes between early and late inter vention for patients with intubation-related laryngeal injury.
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De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma Survival Outcomes

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This systematic review and meta-analysis uses data from studies retrieved f rom an Ovid Medline, Embase, Scopus, and Cochrane Library database search to investigate survival differences between de novo and inverted papilloma–associated sinonasal squamous cell carcinoma pathogenesis.
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