Trabecular Bone is Increased in a Rat Model of Polycystic Ovary Syndrome

xloma.fota13 shared this article with you from Inoreader Trabecular Bone is Increased in a Rat Model of Polycystic Ovary Syndrome Via Experimental and Clinical Endocrinology & Diabetes Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1284-5491 Polycystic ovary syndrome (PCOS) in an intricate disorder characterized by reproductive and metabolic abnormalities that may affect bone quality and strength along with the lifespan. The present study analysed the impact of postnatal androgenization (of a single dose of testosterone propionate 1.25 mg subcutaneously at day 5 of life) on bone development and markers of bone metabolism in adult female Wistar rats. Compared with healthy controls, the results of measurements of micro-computed tomography (microCT) of the distal femur of androgenized rats indicated an increased cortical bone volume voxel bone volume to total volume (VOX BV/TV) and higher trabecular number (Tb.n) with reduced trabecular separation (Tb.sp). A large magnitude effect size was observed in the levels of circulating bone formation Procollagen I N-terminal propeptide (P1NP) at day 60 of life; reabsorption cross-linked C-telopeptide of type I collagen (CTX) markers were similar between the androgenized and control rats at days 60 and 110 of life. The analysis of gene expression in bone indicated elements for an increased bone mass such as the reduction of the Dickkopf-1 factor (Dkk1) a negative regulator of osteoblast differentiation (bone formation) and the reduction of Interleukin 1-b (Il1b), an activator of osteoclast differentiation (bone reabsorption). Results from this study highlight the possible role of the developmental programming on bone microarchitecture with reference to young women with PCOS. [...] Georg Thi eme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extrauterine adenomyoma located in the inguinal region

xloma.fota13 shared this article with you from Inoreader Extrauterine adenomyoma located in the inguinal region: a case report of a 44-year-old woman Via Journal of Surgical Case Reports - current issue Abstract Adenomyomas are benign tumours ma de of smooth muscle cells, endometrial glands and stroma. An extrauterine location is extremely rare with an unknown pathogenesis. Preoperative diagnosis is challenging and pathologic examination is necessary to confirm the diagnosis. Here we present a case report of a 44-year-old woman with a painful non-reducible mass in the right inguinal region without fever or other alarming symptoms 2 months after a laparoscopic hysterectomy. She was treated with a surgical resection of the mass. Extrauterine adenomyoma is a very uncommon entity. Preoperative workup is challenging, as confirmation of the diagnosis can only be achieved by histopathological analysis following surgical excision. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A unique case of medulla oblongata epidermoid cyst

xloma.fota13 shared this article with you from Inoreader A unique case of medulla oblongata epidermoid cyst Via Journal of Surgical Case Reports - current issue Abstract Epidermoid cysts (ECs) are slow-g rowing, benign tumors that represent <2% of all intracranial tumors. ECs can be divided into following two types: extra-axial and intra-axial. Extra-axial ECs are most often positioned in the cerebellopontine angle. Intra-axial ECs, which are also referred to as intraparenchymal ECs, are most commonly found in supratentorial structures, such as the frontal and temporal lobes, accounting for <2% of all intracranial ECs and are especially rare in children. In this report, we described a unique case of medulla oblongata EC in a child, to contribute this knowledge to the existing body of literature. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

An unusual case of hyalinizing clear cell carcinoma in a sinonasal cavity and cranial base

xloma.fota13 shared this article with you from Inoreader An unusual case of hyalinizing clear cell carcinoma in a sinonasal cavity and cranial base Via Journal of Surgical Case Reports - current issue Abstract Hyalinizing clear cell carcinoma (HCCC) is a rare, predominantly minor salivary gland tumor. Most of these tumors occur in the oral cavity, mainly the palate and tongue. Primary localization of the tumor in the region of the nasal cavity and paranasal sinuses is extremely rare and, with only a few cases reported in the literature so far. We present an extremely rare case of a 61-year-old woman with hyalinizing clear cell carcinoma (HCCC), occupying the left posterior nasal and nasopharyngeal cavity, as a primary tumor location. The patient total recovery was uneventful, and she is now free of disease at three years postoperative follow-up. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clipping of a basilar tip aneurysm using hypothermia and circulatory arrest: a case report

xloma.fota13 shared this article with you from Inoreader Clipping of a basilar tip aneurysm using hypothermia and circulatory arrest: a case report Via Journal of Surgical Case Reports - current issue Abstract Treatment of complex and giant an eurysms remains challenging despite modern endovascular and microsurgical techniques. We report the first case of microsurgical clipping of a complex basilar tip aneurysm under circulatory arrest and hypothermia performed in Greece. A 52-year-old patient presented with a Hunt and Hess Grade 4 subarachnoid hemorrhage. The digital subtraction angiography revealed a complex basilar tip aneurysm. Due to aneurysm complexity, we decided for microsurgical clipping under hypothermia and circulatory arrest. We performed a right pterional craniotomy with orbitozygomatic osteotomy. The patient was then put on heart–lung-machine. Following hypothermia and circulatory arrest, the aneurysm was clipped with its complete occlusion. The patient was discharged with no neurological deficits. Clipping of complex aneurysms under hypothermia and cardiac arrest performed by experienced team is a safe alternative when endovascular therapy or bypass technique is not feasible. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Unusual localizations of hydatid cysts

xloma.fota13 shared this article with you from Inoreader Unusual localizations of hydatid cysts: a rare case report from Syria Via Journal of Surgical Case Reports - current issue Abstract Hydatid disease (HD) is an infect ion with the metacestode stage of the tapeworm Echinococcus. It is commonly seen in South America, The Middle East, Eastern Mediterranean, Africa and China. Hydatid cysts usually affect the liver followed by the lungs. Involvement in other organs has been reported. However, in the majority of the cases, cysts are localized in one organ or one region. We report a rare case of a 36-year-old woman who presented to the hospital in Syria with long-standing history of non-specific abdominal pain. Computerized tomography showed several hydatid cysts in the liver, spleen, left lung, mediastinum (adjacent to the aortic arch), both breasts and above the right gluteal muscles. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

To do or not to do: prolapsed, bleeding, rectal polyp, a dilemma in austere circumstances

xloma.fota13 shared this article with you from Inoreader To do or not to do: prolapsed, bleeding, rectal polyp, a dilemma in austere circumstances Via Journal of Surgical Case Reports - current issue Abstract Polyps are defined as abnormal gro wth of tissue from a mucosal surface. Rectal polyps are the most common (2%) cause of gastro-intestinal bleed in children below 10 years. In adults, a rectal polyp presenting as an emergency with irreducible prolapse and massive bleeding causing severe anemia is seldom seen. We present one such case in which surgery was performed under austere circumstances before any investigations, as a life saving measure. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.