Blog Archive

Αλέξανδρος Γ. Σφακιανάκης

Wednesday, September 16, 2020

Medicine by Alexandros G. Sfakianakis

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Non-invasive assessment of endothelial dysfunction: A novel method to predict severe COVID-19?.........................................noninvasive techniques that have recently become available to assess endothelial function: flow-mediated vasodilation as measured by ultrasound of the brachial artery, pulse wave analysis, and finger plethysmography during postischemic hyperemia
Non-invasive assessment of endothelial dysfunction: A novel method to predict severe COVID-19?: Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Sarangini Yoganandamoorthy, M.A.D.S.N. Munasinghe, L.V.U. Wanigasuriya, M.K.K. Priyankara, Saroj JayasingheMethods of Endothelial Function Assessment: Description and ...www.scielo.br › scieloAssessment of endothelial function consists of the analysis of endothelial cells responsiveness to vasodilator or vasoconstrictor stimuli,...
Medicine by Alexandros G.Sfakianakis
09:08
antibodies targeting modified ribonucleotides [METHOD]
Validation strategies for antibodies targeting modified ribonucleotides [METHOD]: Chemical modifications are found on almost all RNAs and affect their coding and noncoding functions. The identification of m6A on mRNA and its important role in gene regulation stimulated the field to investigate whether additional modifications are present on mRNAs. Indeed, modifications including m1A, m5C, m7G, 2'-OMe, and were detected. However, since their abundances are low and tools used for their corroboration...
Medicine by Alexandros G.Sfakianakis
09:04
buccal mucoadhesive films for photodynamic inactivation of Candida albicans
Development and <em>in vitro</em> evaluation of buccal mucoadhesive films for photodynamic inactivation of <em>Candida albicans</em>: Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Camila Felix Vecchi, Rafaela Said dos Santos, Jéssica Bassi da Silva, Hélen Cassia Rosseto, Karina Mayumi Sakita, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça, Marcos Luciano Bruschi
Medicine by Alexandros G.Sfakianakis
09:03
Improved Antimicrobial Properties of Methylene Blue Attached to Silver Nanoparticles
Improved Antimicrobial Properties of Methylene Blue Attached to Silver Nanoparticles: Publication date: Available online 15 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Ermek Belekov, Khomidkhodza Kholikov, Lauren Cooper, Simran Banga, Ali O. ErView allSilver nanoparticles are nanoparticles of silver of between 1 nm and 100 nm in size. While frequently described as being 'silver' some are composed of a large percentage of silver oxide due to their large ratio of surface...
Medicine by Alexandros G.Sfakianakis
09:02
Efficacy of aminolevulinic acid 20% solution combined with photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial
Efficacy of aminolevulinic acid 20% solution combined with photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial: Publication date: Available online 15 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Brian Berman, Neal Bhatia, Daniel Piacquadio, Anna Houlihan, David Davidson, Daniel Siegel
Medicine by Alexandros G.Sfakianakis
09:01
Microelectrode Recording and Radiofrequency Thalamotomy following Focused Ultrasound Thalamotomy
Microelectrode Recording and Radiofrequency Thalamotomy following Focused Ultrasound Thalamotomy: Magnetic resonance imaging-guided focused ultrasound (MRgFUS) is a novel method for stereotactic brain lesioning and has primarily been applied for thalamotomies to treat essential tremor (ET). The electrophysiological properties of previously MRgFUS-sonicated thalamic neurons have not yet been described. We report on an ET patient who underwent an MRgFUS thalamotomy but experienced tremor recurrence....
Medicine by Alexandros G.Sfakianakis
09:01
Percutaneous Foramen Ovale Puncture: Usefulness of Intraoperative CT Control, in the Eventuality of a Narrow Foramen
Percutaneous Foramen Ovale Puncture: Usefulness of Intraoperative CT Control, in the Eventuality of a Narrow Foramen: Background: Balloon compression of the gasserian ganglion has been a well-established percutaneous treatment of trigeminal neuralgia since the 1980s. However, puncture of the foramen ovale by conventional single-plane fluoroscopy can be difficult in cases of local anatomic abnormalities. Case Presentation: We present the case of a 49-year-old woman diagnosed with idiopathic trigeminal...
Medicine by Alexandros G.Sfakianakis
09:00
Circumferential Subannular Tympanoplasty: Panacea for revision tympanoplasty
Circumferential Subannular Tympanoplasty: Panacea for revision tympanoplasty: Publication date: Available online 16 September 2020Source: American Journal of OtolaryngologyAuthor(s): Gautam Bir Singh, Devanshu Kwatra, Sonali Malhotra, Sunil Kumar
Medicine by Alexandros G.Sfakianakis
08:59
Paleontology: The oldest known sperm cells
Paleontology: The oldest known sperm cells: An international team of paleontologists has discovered giant sperm cells in a 100-million year-old female ostracod preserved in a sample of amber. Clearly, the tiny crustacean had mated shortly before being entombed in a drop of tree resin.
Medicine by Alexandros G.Sfakianakis
08:58
Proprioception but not cardiac interoception is related to the rubber hand illusion
Proprioception but not cardiac interoception is related to the rubber hand illusion: Publication date: Available online 16 September 2020Source: CortexAuthor(s): Áron Horváth, Eszter Ferentzi, Tamás Bogdány, Tibor Szolcsányi, Michael Witthöft, Ferenc Köteles
Medicine by Alexandros G.Sfakianakis
08:58
A Pandemic within a Pandemic — Intimate Partner Violence during Covid-19
A Pandemic within a Pandemic — Intimate Partner Violence during Covid-19: As Covid-19 cases surged in the United States in March 2020, stay-at-home orders were put in place. Schools closed, and many workers were furloughed, laid off, or told to work from home. With personal movement limited and people confined to their homes, advocates expressed concern about a potential…
Medicine by Alexandros G.Sfakianakis
08:56
Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer
Fecal Microbiome Alteration May Be a Potential Marker for Gastric Cancer: Although intestinal microbial dysbiosis was confirmed to be associated with many chronic diseases and health status through complicated interaction with the host, the effect on gastric cancer was less studied. In this study, we sequenced the 16S rRNA and 18S rRNA genes of fecal bacteria and fungi, respectively, in 134 gastric cancer patients and 58 healthy controls matched by age and gender. Propensity score matching (PSM)...
Medicine by Alexandros G.Sfakianakis
08:55
Dosimetric feasibility of hypofractionation for SBRT treatment of lymph node oligometastases on the 1.5T MR-linac
Dosimetric feasibility of hypofractionation for SBRT treatment of lymph node oligometastases on the 1.5T MR-linac: Stereotactic body radiation therapy (SBRT) is a non-invasive treatment option which is often considered for focal ablation of oligometastatic disease or primary tumours which are not suitable for surgical resection [1–3]. In SBRT a relatively high irradiation dose is delivered in a limited number of fractions to the target in a highly conformal manner with steep dose gradients to achieve...
Medicine by Alexandros G.Sfakianakis
08:54
Pancreatic ascites managed with a conservative approach: a case report
Pancreatic ascites managed with a conservative approach: a case report: Pancreatic ascites refers to the massive accumulation of pancreatic fluid in the peritoneal cavity and is a rare entity. Chronic alcoholic pancreatitis is the most common cause. Ascites is commonly seen in pat...
Medicine by Alexandros G.Sfakianakis
08:54
A rare case of multisystemic langerhans cell histiocytosis mimicking diffuse neonatal hemangiomatosis
A rare case of multisystemic langerhans cell histiocytosis mimicking diffuse neonatal hemangiomatosis:
Medicine by Alexandros G.Sfakianakis
08:53
Erosive pustular dermatosis after CO2 Laser resurfacing in mother and daughter
Erosive pustular dermatosis after CO2 Laser resurfacing in mother and daughter:
Medicine by Alexandros G.Sfakianakis
08:52
Gamma Knife Radiosurgery as a Primary Treatment for Nonfunctioning Pituitary Adenoma Invading the Cavernous Sinus
Gamma Knife Radiosurgery as a Primary Treatment for Nonfunctioning Pituitary Adenoma Invading the Cavernous Sinus: Objectives: Surgical resection of nonfunctioning pituitary adenoma (NFPA) invading the cavernous sinus (CS) remains a challenging and significant factor associated with incomplete resection. The residual tumor in CS is usually treated with adjuvant stereotactic radiosurgery (SRS), but there is little information concerning SRS as an initial treatment for CS-invading NFPA. In this study,...
Medicine by Alexandros G.Sfakianakis
08:49
Comparison of autologous platelet-rich plasma and chitosan in the treatment of temporomandibular joint osteoarthritis: a retrospective cohort study
Comparison of autologous platelet-rich plasma and chitosan in the treatment of temporomandibular joint osteoarthritis: a retrospective cohort study: Publication date: Available online 16 September 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Fu-Long Li, Chuan-Bin Wu, Hai-Jiang Sun, Qing Zhou
Medicine by Alexandros G.Sfakianakis
08:48
Cutaneous squamous cell carcinoma presenting with facial paralysis: good response to Cemiplimab
Cutaneous squamous cell carcinoma presenting with facial paralysis: good response to Cemiplimab:
Medicine by Alexandros G.Sfakianakis
08:48
Dyskeratosis congenita: reticulate hyperpigmentation, nail dystrophy and leukoplakia
Dyskeratosis congenita: a literature review: SummaryDyskeratosis congenita is a rare hereditary disease that occurs predominantly in males and manifests clinically as the classic triad of reticulate hyperpigmentation, nail dystrophy and leukoplakia. It increases the risk of malignancy and other potentially lethal complications such as bone marrow failure, lung and liver diseases. Mutations in 19 genes are associated with dyskeratosis congenita, and a fifth of the pathogenic mutations are found in...
Medicine by Alexandros G.Sfakianakis
08:47
Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise
Primary, Secondary, and Tertiary Effects of Carbohydrate Ingestion During Exercise: AbstractThe purpose of this current opinion paper is to describe the journey of ingested carbohydrate from 'mouth to mitochondria' culminating in energy production in skeletal muscles during exercise. This journey is conveniently described as primary, secondary, and tertiary events. The primary stage is detection of ingested carbohydrate by receptors in the oral cavity and on the tongue that activate reward and other...
Medicine by Alexandros G.Sfakianakis
08:45
Effects of Cold Atmospheric Pressure Plasma and Disinfecting Agents on Candida albicans in Root Canals of Extracted Human Teeth
Effects of Cold Atmospheric Pressure Plasma and Disinfecting Agents on Candida albicans in Root Canals of Extracted Human Teeth: AbstractReinfection in endodontically treated teeth is linked to the complexity of the root canal system, which is problematic to reach with conventional disinfection methods. As plasma is expected to have the ability to sanitize narrow areas, the aim of this study was to analyze the effect of cold atmospheric pressure plasma (CAP) on Candida albicans in root canals of...
Medicine by Alexandros G.Sfakianakis
08:45
Laser‐assisted nucleic acid delivery
Laser‐assisted nucleic acid delivery: A systematic review: AbstractGene therapy has become an effective treatment modality for some conditions. Laser light may augment or enhance gene therapy through photomechanical, photothermal, and photochemical. This review examined the evidence base for laser therapy to enhance nucleic acid transfection in mammalian cells. An electronic search of MEDLINE, Scopus, EMBASE, Web of Science, and Google Scholar was performed, covering all available years. The PRISMA...
Medicine by Alexandros G.Sfakianakis
08:44
Analysis of drug sensitivity of human high-grade osteosarcoma in a chick chorioallantoic membrane (CAM) model: a proof of principle study
Analysis of drug sensitivity of human high-grade osteosarcoma in a chick chorioallantoic membrane (CAM) model: a proof of principle study: AbstractObjectiveMulti-agent chemotherapy is an important pillar in treatment of high-grade osteosarcoma. In an effort to improve patient survival, it is imperative to determine the effectiveness of new substances. The objective of this study was to investigate whether the chick chorioallantoic membrane (CAM) model can be used to analyze drug sensitivity in high-grade...
Medicine by Alexandros G.Sfakianakis
08:44
CD8+ T Cell Infiltration Predicts Chemoradiosensitivity in Nasopharyngeal or Oropharyngeal Cancer
CD8+ T Cell Infiltration Predicts Chemoradiosensitivity in Nasopharyngeal or Oropharyngeal Cancer: ObjectivesLimited information exists regarding the associations between pre‐existing immune parameters in the tumor immune microenvironment (TIM) and either chemoradiosensitivity or prognosis for patients with squamous cell carcinoma of the nasopharynx or oropharynx involving virus‐related or nonvirus‐related tumors.Study DesignRetrospective cohort study.MethodsWe retrospectively reviewed 141 patients...
Medicine by Alexandros G.Sfakianakis
08:37
Cellular and molecular mechanisms in fibrosis
Cellular and molecular mechanisms in fibrosis: AbstractThe activation of fibroblasts is required for physiological tissue remodeling such as wound healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain persistently activated, the progressive deposition of extracellular matrix proteins leads to tissue fibrosis, which results in dysfunction or even loss of function of the affected organ. Although fibrosis has been recognized as a major cause of morbidity and mortality...
Medicine by Alexandros G.Sfakianakis
08:37
MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4
MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. MicroRNAs (miRNAs) was confirmed to play an active role in the pathogenesis of prostate cancer (PCa). The expression and biological function for miR-92a in PCa remains unknown. In this study, we demonstrated that miR-92a expression was decreased in PCa tissues and cells lines. Overexpression miR-92a inhibited the cell...
Medicine by Alexandros G.Sfakianakis
08:36
Determining the significance of psammoma bodies in pelvic washings
Determining the significance of psammoma bodies in pelvic washings: A 10‐year retrospective review: BackgroundPelvic washing specimens are relatively common and are submitted for patients undergoing gynecologic surgery to evaluate them for metastatic or occult disease. Psammoma bodies are a relatively uncommon finding in these specimens. To date, large‐scale studies of their cytologic‐histologic correlates and thus clinical significance have been limited.MethodsA 10‐year retrospective search for...
Medicine by Alexandros G.Sfakianakis
08:36
Fine needle aspiration cytomorphology of papillary thyroid carcinoma
Fine needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology: BackgroundNeurotrophic tyrosine kinase receptor (NTRK) rearrangement has been reported in a subset of papillary thyroid carcinoma (PTC) cases. Little is known about the cytomorphologic features of NTRK‐rearranged PTC.MethodsWe report an institutional series of 13 fine needle aspiration (FNA) specimens of NTRK‐rearranged PTC with a predominantly...
Medicine by Alexandros G.Sfakianakis
08:35
The Paris System for reporting urinary cytology
Significant reduction of indeterminate (atypical) diagnosis after implementation of The Paris System for reporting urinary cytology: A single‐institution study of more than 27,000 cases: BackgroundUrinary cytology is a noninvasive and cost‐effective diagnostic and surveillance test in the clinical management of urothelial carcinoma (UC). The Paris System for Reporting Urinary Cytology (TPS), published in 2016, introduced definite diagnostic criteria aimed at improving performance in detecting high‐grade...
Medicine by Alexandros G.Sfakianakis
08:34
Loeys‐Dietz syndrome (LDS), a connective tissue disorder characterized by its vascular, skeletal, craniofacial, and cutaneous manifestations is caused by mutations in one of six genes (TGFBR1, TGFBR2, SMAD2, SMAD3, TGFB2, and TGFB3)
The first reported case of Loeys‐Dietz syndrome in a patient with biallelic SMAD3 variants: AbstractLoeys‐Dietz syndrome (LDS), a connective tissue disorder characterized by its vascular, skeletal, craniofacial, and cutaneous manifestations is caused by mutations in one of six genes (TGFBR1, TGFBR2, SMAD2, SMAD3, TGFB2, and TGFB3). Until recently, all reported cases of LDS have been attributed to heterozygous pathogenic variants in these genes. Here, we report the first case of Loeys‐Dietz syndrome...
Medicine by Alexandros G.Sfakianakis
08:33
Totally Robotic Caudate Lobe Liver Resection
Totally Robotic Caudate Lobe Liver Resection: Bridge Over Troubled Water (with video): AbstractBackgroundMinimally invasive hepatectomy has well known advantages over the traditional open approach. Inherent limitations of laparoscopy make major hepatectomies and the resection of upper and posterior segments a great technical challenge. The robotic approach overcomes most of these limitations and this technology is most useful in the resection of the deeply located caudate lobe.MethodsWe describe...
Medicine by Alexandros G.Sfakianakis
08:32
Effects of nerve‐sparing procedures on bowel function after robot‐assisted radical prostatectomy: A longitudinal study
Effects of nerve‐sparing procedures on bowel function after robot‐assisted radical prostatectomy: A longitudinal study: AbstractBackgroundThis study aimed to evaluate rectal pain and bowel function of the patients following robot‐assisted radical prostatectomy (RARP).MethodsWe divided 296 patients who underwent RARP into two groups depending on the intervention: NS group (bilateral nerve‐sparing (NS), unilateral NS, bilateral partial NS) and non‐NS group (unilateral partial NS, bilateral non‐NS)....
Medicine by Alexandros G.Sfakianakis
08:32
negative automatic thoughts
Psychometric properties of the Automatic Thoughts Questionnaire-8 in two Spanish nonclinical samples: Background The ATQ is a widely used instrument consisting of 30 items that assess the frequency of negative automatic thoughts. However, the extensive length of the ATQ could compromise its measurement efficiency in survey research. Consequently, an 8-item shortened version of the ATQ has been developed. This study aims to analyze the validity of the ATQ-8 in two Spanish samples....
Medicine by Alexandros G.Sfakianakis
08:31
Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing:
Medicine by Alexandros G.Sfakianakis
08:29
mutational signatures in head and neck cancer
Unraveling most abundant mutational signatures in head and neck cancer: AbstractGenomic alterations are a driving force in the multistep process of head and neck cancer (HNC) and result from the interaction of exogenous environmental exposures and endogenous cellular processes. Each of these processes leaves a characteristic pattern of mutations on the tumor genome providing the unique opportunity to decipher specific signatures of mutational processes operative during HNC pathogenesis and to address...
Medicine by Alexandros G.Sfakianakis
08:28
Reasons behind the rapid increase of thyroid cancer (TC)
Screening and the Epidemic of Thyroid Cancer in China: An Analysis of National Representative Inpatient and Commercial Insurance Databases: AbstractReasons behind the rapid increase of thyroid cancer (TC) in China are uncertain. We assessed the burden of TC and the role of access to screening and salt iodization. We analyzed two national databases in China: Hospital Quality Monitoring System (HQMS) and China Reinsurance Company (CRC) database. HQMS covered 1,037 (44.3%) class 3 hospitals and 76,263,617...
Medicine by Alexandros G.Sfakianakis
08:28
Optimal management of esophageal cancer
Optimal management of esophageal cancer in Africa: A systemic review of treatment strategies: ABSTRACTEsophageal cancer (EC) is a leading cause of cancer morbidity and mortality in Africa. Despite the high burden of disease, optimal management strategies for EC in resource‐constrained settings have yet to be established. This systematic review evaluates the literature on treatments for EC throughout Africa, and compares the efficacy and safety of varying treatment strategies in this context (PROSPERO...
Medicine by Alexandros G.Sfakianakis
08:27
Nintedanib plus mFOLFOX6 as second‐line treatment of metastatic, chemorefractory colorectal cancer: the randomized, placebo‐controlled, phase II TRICC‐C study (AIO‐KRK‐0111)
Nintedanib plus mFOLFOX6 as second‐line treatment of metastatic, chemorefractory colorectal cancer: the randomized, placebo‐controlled, phase II TRICC‐C study (AIO‐KRK‐0111): AbstractNintedanib is a triple angiokinase‐inhibitor of VEGF‐receptor 1‐3, FGF‐receptor 1‐3 and PDGF‐receptor‐a/‐b. Thereby it targets angiogenic escape mechanisms. The TRICC‐C trial evaluates the addition of nintedanib to mFOLFOX6 in patients with mCRC. TRICC‐C is a randomized controlled, double‐blinded, phase II trial in mCRC...
Medicine by Alexandros G.Sfakianakis
08:27
Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer
African‐specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer: AbstractPolygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46), showed reduced performance in men with African genetic ancestry. We used a cross‐validated search to identify SNPs that might improve performance in this population. Anonymized genotypic data were obtained from the PRACTICAL consortium for 6,253 men with African...
Medicine by Alexandros G.Sfakianakis
08:26
Nasopharyngeal Carcinoma in Children and Adolescents
Clinicopathological and Prognostic Features of Nasopharyngeal Carcinoma in Children and Adolescents: A Retrospective Study of 196 Cases in South China: AbstractNasopharyngeal carcinoma (NPC) occurring in children and adolescence is extremely rare and till present there is a lack of understanding on their clinicopathological and prognostic features of this rare entity. For this study, data of 196 cases children and adolescents with NPC from the past 18 years at a high‐volume cancer center from South...
Medicine by Alexandros G.Sfakianakis
08:25
Overdiagnosis in lung cancer screening
Overdiagnosis in lung cancer screening – estimates from the German Lung Cancer Screening Intervention Trial.: AbstractOverdiagnosis is a major potential harm of lung cancer screening; knowing its potential magnitude helps to optimize screening eligibility criteria.The German Lung Screening Intervention Trial ("LUSI") is a randomized trial among 4052 long‐term smokers (2622 men), 50.3‐71.9 years of age from the general population around Heidelberg, Germany, comparing five annual rounds of low‐dose...
Medicine by Alexandros G.Sfakianakis
08:25
Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome
Value of upper GI endoscopy for gastric cancer surveillance in patients with Lynch syndrome: AbstractIn this study we evaluated the effectiveness of upper GI endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analysing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicentre cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was...
Medicine by Alexandros G.Sfakianakis
08:24
Prophylaxis of Post-Inflammatory Hyperpigmentation From Energy-Based Device Treatments: A Review
Prophylaxis of Post-Inflammatory Hyperpigmentation From Energy-Based Device Treatments: A Review: Journal of Cutaneous Medicine and Surgery, Ahead of Print. Post-inflammatory hyperpigmentation (PIH) is an acquired hypermelanosis that can result from inflammatory dermatologic disease, trauma, or iatrogenesis from procedures. This condition disproportionately affects individuals with skin of color, and it can place a significant psychosocial burden on affected patients. The management of PIH is, therefore,...
Medicine by Alexandros G.Sfakianakis
08:24
Management of an Imminent Pathological Fracture of a Fibular Neomandible Via a Minimally‐Invasive Approach – A Case Report
Management of an Imminent Pathological Fracture of a Fibular Neomandible Via a Minimally‐Invasive Approach – A Case Report: AbstractFibular free flap reconstruction remains the workhorse of the post‐mandibulectomy reconstruction. Dental implantation to support a dental prosthesis is a sought‐after outcome when the area of resection involves tooth‐bearing zones.Chronic peri‐soft tissue pedicle hyperplasia with secondary infection leading to gradual bone loss is a simple complication to manage in the...
Medicine by Alexandros G.Sfakianakis
08:23
preoperative microvessel evaluation and characterization in perforator flaps using various modes of color‐coded duplex sonography (CCDS)
Feasibility study of preoperative microvessel evaluation and characterization in perforator flaps using various modes of color‐coded duplex sonography (CCDS): AbstractBackgroundColor‐coded duplex sonography (CCDS) is useful for perforator flap design showing the highest sensitivity in identifying microvessels. This prospective study evaluates the feasibility of different ultrasound (US) modes applied by the microsurgeon in daily practice suggesting quantifiable reference values.MethodsTwenty‐four...
Medicine by Alexandros G.Sfakianakis
08:22
Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma
Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma: Background Galectins (Gal) are a family of protein that bind to the β-galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis. A series of experimental and clinical evidences have been reported to support a correlation between galectin expressions and neoplastic transformation, progression and prognosis. The objective...
Medicine by Alexandros G.Sfakianakis
08:21
Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation – Focus on the medial forebrain bundle
Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation – Focus on the medial forebrain bundle: AbstractDeep Brain Stimulation (DBS) in psychiatric illnesses has been clinically tested over the past 20 years. The clinical application of DBS to the superolateral branch of the medial forebrain bundle in treatment resistant depressed patients – one of several targets under investigation ‐ has shown to be promising in a number...
Medicine by Alexandros G.Sfakianakis
08:20
Cortical responses to whole‐body balance perturbations index perturbation magnitude and predict reactive stepping behavior
Cortical responses to whole‐body balance perturbations index perturbation magnitude and predict reactive stepping behavior: AbstractThe goal of this study was to determine whether the cortical responses elicited by whole‐body balance perturbations were similar to established cortical markers of action monitoring. Postural changes imposed by balance perturbations elicit a robust negative potential (N1) and a brisk increase of theta activity in the electroencephalogram recorded over midfrontal scalp...
Medicine by Alexandros G.Sfakianakis
08:19
Modulation of binocular rivalry with rapid monocular visual stimulation
Modulation of binocular rivalry with rapid monocular visual stimulation: AbstractRapid visual stimulation can increase synaptic efficacy by repeated synaptic activation. This long‐term potentiation‐like (LTP‐like) effect can induce increased excitability in the human visual cortex. To examine the effect of rapid visual stimulation on perception, we tested the hypothesis that rapid monocular visual stimulation would increase the dominance of the stimulated eye in a binocular rivalry task. Participants...
Medicine by Alexandros G.Sfakianakis
08:19
chitinase‐3‐like protein 1 in recurrence patterns among patients with differentiated thyroid cancer
Exploring the role of chitinase‐3‐like protein 1 in recurrence patterns among patients with differentiated thyroid cancer: a commentary: AbstractOur understanding of the oncogenic drivers involved in thyroid cancers continues to expand. In a recent issue of this journal, Cheng et al explore the role of Chitinase‐3‐like protein 1 (CHI3L1) in the development of thyroid cancer and its recurrence. They show increased levels of CHI3L1 in papillary and anaplastic thyroid malignancies (PTC and ATC, respectively)...
Medicine by Alexandros G.Sfakianakis
08:18
Lungs Infected With Sars‐Cov 2.......Immunohistochemistry for the receptor of the SARS‐COV 2, ACE2, and its priming activatorTMPRSS2 revealed that both proteins co‐localize in airway cells. In particular, the ACE2 protein was expressed in both endothelial cells and alveolar type I and II pneumocytes in the areas of histological diffuse alveolar damage (DAD). Pneumocytes but not endothelial cells also expressed TMPRSS2. There are no distinctive histological features of SARS‐COV 2 infection with respect to SARS‐COV 1 and other DAD with different aetiology.
Pathological Post Mortem Findings in Lungs Infected With Sars‐Cov 2: AbstractItaly was the first European nation to be massively infected by SARS‐COV 2. Up to the end of May 2020 more than thirty‐three thousand deaths had been recorded in Italy with a large prevalence among males, those over 75 years of age, and in association with co‐morbidities. We describe the lung pathological and immunohistochemical post‐mortem findings at the autopsy of 9 patients who died of SARS‐COV 2 associated disease....
Medicine by Alexandros G.Sfakianakis
08:17
Functional Communication Profiles of Children and Youth with Autism: A Roadmap to Therapeutic and Educational Interventions
Functional Communication Profiles of Children and Youth with Autism: A Roadmap to Therapeutic and Educational Interventions: Background: Autism spectrum disorder (ASD) entails varied developmental pathways along the entire lifespan, demanding early and ongoing diverse and responsive interventions to children's needs. This study examined in situ education and development attained by children and youth with ASD in a school with a therapeutic and educational curriculum. Objectives: (1) Construct individual...
Medicine by Alexandros G.Sfakianakis
08:16
Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific vs. progressive supranuclear palsy (PSP).Network localization of alien limb in patients with corticobasal syndrome
Network localization of alien limb in patients with corticobasal syndrome: OBJECTIVEPerirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific vs. progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS‐specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion‐induced disorders...
Medicine by Alexandros G.Sfakianakis
08:16
Fear of Cancer Recurrence in Patients with Multiple Myeloma: Prevalence and Predictors Based on a Family Model Analysis
Fear of Cancer Recurrence in Patients with Multiple Myeloma: Prevalence and Predictors Based on a Family Model Analysis: AbstractObjectiveFear of cancer recurrence (FCR) is a common psychosocial sequela among cancer survivors, but data on patients with multiple myeloma are scarce. This study calculated the prevalence of FCR and identified family and social factors that predict FCR in the study population.MethodsWe recruited 127 myeloma patients and their partners to participate in a cross‐sectional...
Medicine by Alexandros G.Sfakianakis
08:14
electronic psychosocial screening in pediatric oncology
Using formative evaluation to plan for electronic psychosocial screening in pediatric oncology: AbstractObjectiveTo demonstrate how formative research methods can be used to plan for implementation of evidence‐based psychosocial screening in pediatric oncology.MethodsMultidisciplinary pediatric oncology professionals participated in focus groups to adapt the Distress Thermometer (DT) for electronic administration and develop health systems processes to promote psychosocial screening in the pediatric...
Medicine by Alexandros G.Sfakianakis
08:13
losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR
A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with solid tumors likely to overexpress EGFR: SummaryLosatuxizumab vedotin (formerly ABBV-221) is a second-generation antibody-drug conjugate targeting epidermal growth factor receptor (EGFR). In this multicenter phase 1 study, eligible patients with EGFR-dependent solid tumors received losatuxizumab vedotin (3 + 3 design) intravenously...
Medicine by Alexandros G.Sfakianakis
08:13
Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood
Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood: SummaryAdministration of chemotherapeutics as direct injections into tumors offers increased anti-tumor activity and reduced systemic toxicity. In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects of intratumoral (IT) submicron particle docetaxel (NanoDoce®) on tumor growth and immunomodulation....
Medicine by Alexandros G.Sfakianakis
08:12
Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types
Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types: SummaryCancer is one of the leading causes of death worldwide, but effective therapies remain the topic of many research activities. Many recent studies have thus focused on particular gut microbiota due to their important roles in treating cancers, but very few microbes of therapeutic value have been reported. In this study, we isolated four bacterial strains, BY38, BY40, BY43 and BY45, from...
Medicine by Alexandros G.Sfakianakis
08:11
adjuvant trastuzumab on locoregional failure rates
Impact of adjuvant trastuzumab on locoregional failure rates in a randomized clinical trial: North Central Cancer Treatment Group N9831 (alliance) study: BackgroundThe goal of this study was to assess the impact of trastuzumab on locoregional failure.METHODSThe analysis included 2763 patients with HER2‐positive (HER2+) breast cancer who were randomly assigned to adjuvant doxorubicin (A), cyclophosphamide (C), paclitaxel (T) and trastuzumab (H) (arm A, AC→T [n = 922]; arm B, AC→T→H [n = 988]; arm...
Medicine by Alexandros G.Sfakianakis
08:11
carbon‐ion radiotherapy for patients with locoregionally recurrent nasopharyngeal carcinoma
Clinical outcomes of carbon‐ion radiotherapy for patients with locoregionally recurrent nasopharyngeal carcinoma: BackgroundReirradiation for locoregionally recurrent nasopharyngeal carcinoma (LR‐NPC) after high‐dose radiotherapy (RT) is challenging and usually is associated with poor survival and severe toxicities. Because of its physical and biological advantages over photon‐beam RT, carbon‐ion RT (CIRT) could be a potential treatment option for patients with LR‐NPC.MethodsPatients with LR‐NPC...
Medicine by Alexandros G.Sfakianakis
08:10
Association between postoperative complications and long‐term oncologic outcomes following total laryngectomy: 10‐year experience at MD Anderson Cancer Center
Association between postoperative complications and long‐term oncologic outcomes following total laryngectomy: 10‐year experience at MD Anderson Cancer Center: BackgroundPostoperative complications are an independent predictor of poor survival across several tumors. However, there is limited literature on the association between postoperative morbidity and long‐term survival following total laryngectomy (TL) for cancer.MethodsWe conducted a retrospective review of all TL patients at a single institution...
Medicine by Alexandros G.Sfakianakis
08:09
Hyperthermic intraperitoneal chemotherapy in interval debulking surgery for advanced epithelial ovarian cancer: A single‐center, real‐life experience
Hyperthermic intraperitoneal chemotherapy in interval debulking surgery for advanced epithelial ovarian cancer: A single‐center, real‐life experience: BackgroundAn improvement in survival without increasing perioperative morbidity in patients with advanced epithelial ovarian cancer treated with hyperthermic intraperitoneal chemotherapy (HIPEC) after interval debulking surgery (IDS) has been recently demonstrated in a randomized controlled trial. This study was aimed at assessing the feasibility and...
Medicine by Alexandros G.Sfakianakis
08:09
5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma
An in vitro study of the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma: AbstractBackgroundThe primary aim of this study was to observe the effect of 5-ALA-mediated photodynamic therapy on oral squamous cell carcinoma in vitro. MethodsSCC25 cells were divided into the observation group and the blank control group. Different concentrations of 5-ALA and SCC25 cells were co-incubated for different times, and the concentration of protoporphyrin IX...
Medicine by Alexandros G.Sfakianakis
08:07
Early fiberoptic endoscopic evaluation of swallow in transoral robotic surgery: Description of swallow function and recovery in the acute postoperative period for oropharyngeal squamous cell carcinoma
Early fiberoptic endoscopic evaluation of swallow in transoral robotic surgery: Description of swallow function and recovery in the acute postoperative period for oropharyngeal squamous cell carcinoma: AbstractBackgroundTransoral robotic surgery (TORS) is a minimally invasive approach for the treatment of oropharyngeal cancer. The effects on swallowing and speech need to be comprehensively evaluated to understand the associated morbidity.MethodsA prospective cohort of 21 patients was recruited to...
Medicine by Alexandros G.Sfakianakis
08:06
Transoral robotic parapharyngeal approach to the submandibular space
Transoral robotic parapharyngeal approach to the submandibular space: AbstractThe aim of the study was to demonstrate a novel transoral parapharyngeal approach to the submandibular space. The method used was the clinical case of a patient presenting with an anteriorly based tumor in the left submandibular space. The video shows the transoral robotic technique for access to the submandibular space through the parapharyngeal space for removal of the tumor. This approach allows for high definition visibility...
Medicine by Alexandros G.Sfakianakis
08:06
nodal and distant metastases in sinonasal adenocarcinoma
Population‐based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma: AbstractBackgroundMinimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC).MethodsThe Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease‐specific survival (DSS).ResultsOf the 325 patients with SNAC identified, 5‐year and 10‐year...
Medicine by Alexandros G.Sfakianakis
08:05
Pediatric Rigid Bronchoscopy for Tracheobronchial Foreign Bodies
Pediatric Rigid Bronchoscopy for Tracheobronchial Foreign Bodies in Covid Times: Short Personal Experience: AbstractThis case series of 5 patients of rigid bronchoscopy done for tracheobronchial foreign bodies is presented to readers to share my experience of doing rigid bronchoscopy during Covid Times from March to July 2020 specifically sharing experience on personal protection with local innovations during the procedure. Indications, intra-procedure modifications and other relevant things are...
Medicine by Alexandros G.Sfakianakis
08:05
Iodine Concentration in Dual-Energy Computed Tomography of the Chest and Abdomen
Intraindividual Consistency of Iodine Concentration in Dual-Energy Computed Tomography of the Chest and Abdomen: Objectives Dual-energy computed tomography (DECT)–derived quantification of iodine concentration (IC) is increasingly used in oncologic imaging to characterize lesions and evaluate treatment response. However, only limited data are available on intraindividual consistency of IC and its variation. This study investigates the longitudinal reproducibility of IC in organs, vessels, and...
Medicine by Alexandros G.Sfakianakis
08:04
MRI Techniques for Imaging Blood-Brain Barrier Integrity
A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity: The blood-brain barrier (BBB) is the interface between the blood and brain tissue, which regulates the maintenance of homeostasis within the brain. Impaired BBB integrity is increasingly associated with various neurological diseases. To gain a better understanding of the underlying processes involved in BBB breakdown, magnetic resonance imaging (MRI) techniques are highly suitable for noninvasive BBB assessment. Commonly...
Medicine by Alexandros G.Sfakianakis
08:04
Fusion of Preinterventional MR Imaging With Liver Perfusion CT After RFA of Hepatocellular Carcinoma: Early Quantitative Prediction of Local Recurrence
Fusion of Preinterventional MR Imaging With Liver Perfusion CT After RFA of Hepatocellular Carcinoma: Early Quantitative Prediction of Local Recurrence: Objectives The aim of this study was to evaluate the ability of fusion of pretreatment magnetic resonance (MR) imaging with posttreatment perfusion–CT (P-CT) after radiofrequency ablation (RFA) of hepatocellular carcinomas (HCCs) and to determine treatment success in an objective, quantitative way. Materials and Methods In this institutional...
Medicine by Alexandros G.Sfakianakis
08:03
CT Dosimetry: What Has Been Achieved and What Remains to Be Done
CT Dosimetry: What Has Been Achieved and What Remains to Be Done: Radiation dose in computed tomography (CT) has become a hot topic due to an upward trend in the number of CT procedures worldwide and the relatively high doses associated with these procedures. The main aim of this review article is to provide an overview of the most frequently used metrics for CT radiation dose characterization, discuss their strengths and limitations, and present patient dose assessment methods. Computed tomography...
Medicine by Alexandros G.Sfakianakis
08:03
A Magnetic Resonance Imaging Radiomics Signature to Distinguish Benign From Malignant Orbital Lesions
A Magnetic Resonance Imaging Radiomics Signature to Distinguish Benign From Malignant Orbital Lesions: Objectives Distinguishing benign from malignant orbital lesions remains challenging both clinically and with imaging, leading to risky biopsies. The objective was to differentiate benign from malignant orbital lesions using radiomics on 3 T magnetic resonance imaging (MRI) examinations. Materials and Methods This institutional review board–approved prospective single-center study enrolled...
Medicine by Alexandros G.Sfakianakis
08:02
Left heart bypass versus circulatory arrest for open repair of thoracoabdominal aortic pathologies
Left heart bypass versus circulatory arrest for open repair of thoracoabdominal aortic pathologies: Our meta‐analysis found equivalent outcomes between left heart bypass and hypothermic circulatory arrest for open repair of thoracic aortic and thoracoabdominal aortic pathologies. Clinical outcomes evaluated were 30‐day mortality, post‐operative stroke, spinal cord deficit, renal failure and respiratory failure. AbstractBackgroundMost large‐volume centres use left heart bypass (LHB) as their preferred...
Medicine by Alexandros G.Sfakianakis
08:02
Systematic review of perioperative mortality risk prediction models for adults undergoing inpatient non‐cardiac surgery
Systematic review of perioperative mortality risk prediction models for adults undergoing inpatient non‐cardiac surgery: Risk prediction tools can be used in the perioperative setting to identify high‐risk patients who may benefit from increased surveillance and monitoring in the postoperative period, to aid shared decision‐making, and to benchmark risk‐adjusted hospital performance. We evaluated perioperative risk prediction tools relevant to an Australian context. AbstractBackgroundRisk prediction...
Medicine by Alexandros G.Sfakianakis
08:01
Gene signatures from scRNA‐seq accurately quantify mast cells in biopsies in asthma
Gene signatures from scRNA‐seq accurately quantify mast cells in biopsies in asthma: AbstractRespiratory disease, characterized by changes in the cells of the lung, can affect molecular phenotype of cells and the intercellular interactions, resulting in a disbalance in the relative proportions of individual cell types. Understanding these changes is essential to understand the pathophysiology of lung disease. Conventional 'bulk' RNA‐sequencing (RNA‐seq), analyzing the entire transcriptome of the...
Medicine by Alexandros G.Sfakianakis
07:59
Acute Cholecystitis during Lenvatinib for Advanced Thyroid Cancer
High Prevalence and Conservative Management of Acute Cholecystitis during Lenvatinib for Advanced Thyroid Cancer: Introduction: Lenvatinib (LEN) is a multitarget tyrosine kinase inhibitor currently used for advanced, radioiodine refractory differentiated thyroid cancer (RAI-R DTC). Among adverse events (AEs), nausea, vomiting, and decreased appetite have been frequently described. We aimed to evaluate the prevalence, the clinical presentation, and the effectiveness of conservative treatment of gallbladder...
Medicine by Alexandros G.Sfakianakis
07:59
Insulin‐induced amyloidoma—A cytological catch
Insulin‐induced amyloidoma—A cytological catch:
Medicine by Alexandros G.Sfakianakis
07:58
Low Diagnostic Yield of Repeat Blood Cultures in Adult Hematologic Malignancy Patients with Persistent Neutropenic Fever
Low Diagnostic Yield of Repeat Blood Cultures in Adult Hematologic Malignancy Patients with Persistent Neutropenic Fever: AbstractFever complicates chemotherapy‐induced neutropenia in >80% of patients with hematologic malignancies. Microbiologically documented infections occur in 22%–39% of febrile episodes; common sites of tissue‐based infection include the intestinal tract, lung, and skin. Bacteremia is established in 18% of patients on fluoroquinolone prophylaxis versus 34% of patients not...
Medicine by Alexandros G.Sfakianakis
07:57
Biallelic intronic AAGGG expansion of RFC1 is related to multiple system atrophy
Biallelic intronic AAGGG expansion of RFC1 is related to multiple system atrophy: ObjectiveA recessive biallelic repeat expansion, (AAGGG)exp, in the RFC1 gene has been reported to be a frequent cause of late‐onset ataxia. For cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS), the recessive biallelic (AAGGG)exp genotype was present in approximately 92% of cases. This study aimed to examine whether the pentanucleotide repeat (PNR) was related to multiple system atrophy (MSA)...
Medicine by Alexandros G.Sfakianakis
07:56
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function [NEW RESULTS]
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function [NEW RESULTS]: Background: The emergence of a novel coronavirus (SARS-CoV-2) associated with severe acute respiratory disease (COVID-19) has prompted efforts to understand the genetic basis for its unique characteristics and its jump from non-primate hosts to humans. Tests for positive selection can identify apparently nonrandom patterns of mutation accumulation within genomes, highlighting...
Medicine by Alexandros G.Sfakianakis
07:56


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    Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
    Telephone consultation 11855 int 1193,