Cancer Biotherapy and Radiophamaceuticals

Cancer Biotherapy and Radiophamaceuticals

Original Articles

Design, Synthesis, Radiolabeling, and Biologic Evaluation of Three 18F-FDG-Radiolabeled Targeting Peptides for the Imaging of Apoptosis

• Sepideh Khoshbakht, 
• Davood Beiki, 
• Parham Geramifar, 
• Farzad Kobarfard, 
• Omid Sabzevari, 
• Mohsen Amini, 
• Noushin Bolourchian, 
• Danial Shamshirian, and 
• Soraya Shahhosseini

• Pages:271–279
• Published Online:4 March 2019

https://doi.org/10.1089/cbr.2018.2709

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Abstract Background: Early detection of apoptosis is very important for therapy and follow-up treatment in various pathologic conditions. Annexin V interacts strongly and specifically with phosphatidylserine, specific biomarkers of apoptosis with some ...

177Lu/153Sm-Ethylenediamine Tetramethylene Phosphonic Acid Cocktail: A Novel Palliative Treatment for Patients with Bone Metastases

• Mehrosadat Alavi, 
• Farnaz Khajeh-Rahimi, 
• Hassan Yousefnia, 
• Mohammad Mohammadianpanah, 
• Samaneh Zolghadri, 
• Ali Bahrami-Samani, and 
• Mohammad Ghannadi-Maragheh

• Pages:280–287
• Published Online:12 April 2019

https://doi.org/10.1089/cbr.2018.2683

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Abstract Background: Production of effective, low-cost, and efficient radiopharmaceuticals is an important task and requires further research and clinical studies. In this clinical trial, safety and efficacy of 177Lu/153Sm-ethylenediamine tetramethylene ...

89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma

• Raquel Benedetto, 
• Adriana V.F. Massicano, 
• Bryant K. Crenshaw, 
• Renato Oliveira, 
• Rui M. Reis, 
• Elaine B. Araújo, and 
• Suzanne E. Lapi

• Pages:288–296
• Published Online:13 March 2019

https://doi.org/10.1089/cbr.2018.2616

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Abstract Background: Despite the improvement in clinical outcomes for head and neck squamous cell carcinoma (HNSCC) as the result of cetuximab, patients may present with or develop resistance that increases tumor recurrence rates and limits clinical ...

Antitumor Effects of Ruyiping on Cell Growth and Metastasis in Breast Cancer

• Zhiyuan Li, 
• Xiaohui Sun, 
• Xiaoming Liu, 
• Ziyuan Sun, and 
• Jingwei Li

• Pages:297–305
• Published Online:22 March 2019

https://doi.org/10.1089/cbr.2018.2703

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Abstract Background: Ruyiping is an effective traditional Chinese herbal medicine formula for preventing postoperative recurrence and metastasis of breast cancer. However, the exact function and underlying mechanism of Ruyiping in breast cancer remain ...

Synthesis and Preliminary Biological Evaluation of 177Lu-Labeled Polyhydroxamic Acid Microparticles Toward Therapy of Hepatocellular Carcinoma

• Usha Pandey, 
• Suresh Subramanian, 
• Samina Shaikh, 
• Naresh Gamre, 
• Sanjukta Kumar, and 
• Ashutosh Dash

• Pages:306–315
• Published Online:11 June 2019

https://doi.org/10.1089/cbr.2018.2747

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Abstract Background: Transarterial radioembolization (TARE) represents an effective targeted therapeutic option for hepatocellular carcinoma (HCC), a cancer with high mortality and poor prognosis. The aim of this study was the preparation and preliminary ...

LncRNA KB-1471A8.2 Overexpression Suppresses Cell Proliferation and Migration and Antagonizes the Paclitaxel Resistance of Ovarian Cancer Cells

• Mi Zhang, 
• Siyu Liu, 
• Chenyang Fu, 
• Xusu Wang, 
• Min Zhang, 
• Guangquan Liu, 
• Chencheng Dai, 
• Zhen Gong, 
• Hanzi Xu, 
• Ziyi Fu, 
• Pengfei Xu, 
• Juan Xu, and 
• Xuemei Jia

• Pages:316–324
• Published Online:20 March 2019

https://doi.org/10.1089/cbr.2018.2698

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Abstract Objective: The aim was to investigate the lncRNA KB-1471A8.2 function in ovarian cancer progression and paclitaxel resistance. Methods: The expression and distribution of KB-1471A8.2 was detected by qRT-PCR. The cell proliferation, apoptosis, ...

Elevated Circulating CD4+CD25−Foxp3+ Regulatory T Cells in Patients with Nonsmall Cell Lung Cancer

• Xintong Hu, 
• Yue Gu, 
• Songchen Zhao, 
• Shucheng Hua, and 
• Yanfang Jiang

• Pages:325–333
• Published Online:29 March 2019

https://doi.org/10.1089/cbr.2018.2672

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Abstract Purpose: CD4+CD25+Foxp3+ regulatory T (Treg) cell-mediated immunosuppression has been implicated as a crucial mechanism of tumor immune cell escape in nonsmall cell lung cancer (NSCLC). However, little is known concerning the specific role of CD4+...

miR-4429 Inhibits Tumor Progression and Epithelial-Mesenchymal Transition Via Targeting CDK6 in Clear Cell Renal Cell Carcinoma

• Hong Pan, 
• Yejing Hong, 
• Biying Yu, 
• Li Li, and 
• Xiaojian Zhang

• Pages:334–341
• Published Online:7 March 2019

https://doi.org/10.1089/cbr.2018.2697

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Abstract Background: Clear cell renal cell carcinoma (ccRCC), as the commonest type among renal cell cancers, is featured with easy relapse and metastasis. Despite mounting achievements on its treatment and diagnosis, the identification of new biomarkers ...

⁸⁹Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma 
Raquel Benedetto, Adriana V.F. Massicano, Bryant K. Crenshaw, Renato Oliveira, Rui M. Reis, Elaine B. Araújo, and Suzanne E. Lapi  Read Now

Synthesis and Preliminary Biological Evaluation of ¹⁷⁷Lu-Labeled Polyhydroxamic Acid Microparticles Toward Therapy of Hepatocellular Carcinoma 
Usha Pandey, Suresh Subramanian, Samina Shaikh, Naresh Gamre, Sanjukta Kumar, and Ashutosh Dash  Read Now

Design, Synthesis, Radiolabeling, and Biologic Evaluation of Three ¹⁸F-FDG-Radiolabeled Targeting Peptides for the Imaging of Apoptosis 
Sepideh Khoshbakht, Davood Beiki, Parham Geramifar, Farzad Kobarfard, Omid Sabzevari, Mohsen Amini, Noushin Bolourchian, Danial Shamshirian, and Soraya Shahhosseini  Read Now

¹⁷⁷Lu/¹⁵³Sm-Ethylenediamine Tetramethylene Phosphonic Acid Cocktail: A Novel Palliative Treatment for Patients with Bone Metastases
Mehrosadat Alavi, Farnaz Khajeh-Rahimi, Hassan Yousefnia, Mohammad Mohammadianpanah, Samaneh Zolghadri, Ali Bahrami-Samani, and Mohammad Ghannadi-Maragheh  Read Now