Brief Communication PD1-related Nephrotoxicity: Optimizing Its Clinical Management Through Histopathologic Features

alwin shared this article with you from Inoreader Brief Communication PD1-related Nephrotoxicity: Optimizing Its Clinical Management Through Histopathologic Features Via Journal of Immunotherapy Immune-related nephrotoxicity (ir-N) is a rare adverse event of immune-checkpoint(s) inhibitors (ICI) therapy and its clinical management is still debated. Among 501 consecutive ICI-treated patients at our Institution, 6 who developed an ir-N with clinical signs suggestive for an acute kidney injury underwent kidney biopsy. Histology showed an acute tubule-interstitial nephritis, simulating the scenario of acute T-cell–mediated kidney transplant rejection. Thus, the management of allograft kidney rejection routinely utilized at our clinic was implemented, leading to rapid renal function improvement. Histologic features supporting the definition of an immune-mediated acute kidney injury in ICI-treated patients may help optimizing the clinical management of ir-N. (Source: Journal of Immuno... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia

alwin shared this article with you from Inoreader Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia Via Innate Immunity Innate Immun. 2022 Jan;28(1):37-48. doi: 10.1177/17534259211069104.ABSTRACTCircular RNA (circRNA) represents an important regulator in infantile pneumonia progression. To clarify the role of circ_0026579 in this disease, LPS was used to treat WI-38 cells to mimic inflammation injury. The levels of inflammatory factors were determined by ELISA assay. Cell proliferation and apoptosis were measured by MTT assay, EdU staining and flow cytometry. The protein levels of cyclinD1, cleaved-caspase-3 and insulin-like growth factor 2 (IGF2) were examined using Western blot analysis. Cell oxidative stress was assessed by detecting MDA level and SOD activity. The expression of circ_0026579, miR-24-3p and IGF2 were analyzed using quantitative real-time PCR, and the interaction between miR-24-3p and circ... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Outcomes of Oral Epithelial Dysplasia Managed by Observation versus Excision at a Canadian Tertiary Centre

alwin shared this article with you from Inoreader Outcomes of Oral Epithelial Dysplasia Managed by Observation versus Excision at a Canadian Tertiary Centre Via Journal of Oral and Maxillofacial Surgery There is a lack of consensus in the management of oral epithelial dysplasia (OED). The purpose of this study is: 1) to evaluate whether surgical excision with histologically negative margins impacts the 5-year malignant transformation rate of OED, and 2) to compare the disease-specific survival outcome of patients diagnosed with oral squamous cell carcinoma (OSCC) that progressed from OED to those presenting with OSCC on initial biopsy. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mandible Fracture Patterns after Low Kinetic Energy Trauma Common in an Urban Level I Trauma Center

alwin shared this article with you from Inoreader Mandible Fracture Patterns after Low Kinetic Energy Trauma Common in an Urban Level I Trauma Center Via Journal of Oral and Maxillofacial Surgery Facial trauma and fractures are injuries that may require attention from emergency departments (ED). The Nationwide Emergency Department reported that in 2007 alone 407,167 ED visits included a facial fracture, with annual costs close to $1 billion.1 Of these, 1 of the most common injury sites of the maxillofacial region is the mandible.2 Despite previous studies having shown trends in etiology, epidemiology, and treatment outcomes, there is still no consensus on culture-, city-, and facility-specific variables by reporting trauma centers.3 For example, some studies mention motor vehicle accidents and interpersonal violence as leading causes of mandibular fractures, while other studies list falls, all with varying geographic influences as well. (Source: Journal of Oral and Maxillofacial Su... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Head and Neck Langerhans Cell Histiocytosis in Children

alwin shared this article with you from Inoreader Head and Neck Langerhans Cell Histiocytosis in Children Via Journal of Oral and Maxillofacial Surgery Langerhans Cell Histiocytosis (LCH) is a sporadic myeloid neoplasm with proliferation of dendritic cells.1 In the United States, LCH has an estimated annual incidence of approximately 1 per million children.2 Controversy exists regarding management of LCH in head and neck: debridement, chemotherapy, or both. Few reports describe LCH in the OMS literature. The purpose of this study was to present experience with LCH of head and neck in children.This was a retrospective review of children with LCH at Children's Healthcare of Atlanta from 2009 to 2020. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions?

alwin shared this article with you from Inoreader Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions? Via Journal of Oral and Maxillofacial Surgery It is unclear whether certain bacteria initiate the development of inflammatory jaw conditions, or whether these diseases create a milieu for dysbiosis and secondary colonization of indigenous flora. At present, there are no comparative studies on the types of bacteria that colonize different inflammatory jaw conditions. Accordingly, this study aims to identify and compare the types of bacteria isolated in osteomyelitis, osteoradionecrosis, and MRONJ. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Treatment of sagittal fracture of the mandibular condyle using resorbable-screw osteosynthesis

alwin shared this article with you from Inoreader Treatment of sagittal fracture of the mandibular condyle using resorbable-screw osteosynthesis Via Journal of Oral and Maxillofacial Surgery This study aimed to explore the applicability of resorbable-screw osteosynthesis in the treatment of SFMC. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Females Have Worse Overall and Disease-Specific Survival In HPV-Negative Oropharyngeal Squamous Cell Carcinoma

alwin shared this article with you from Inoreader Females Have Worse Overall and Disease-Specific Survival In HPV-Negative Oropharyngeal Squamous Cell Carcinoma Via Journal of Oral and Maxillofacial Surgery Although sex (male versus female) has been identified as an independent prognostic factor in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC), the role of sex in HPV-negative OPSCC is less understood. The purpose of this study was to measure the association between sex and HPV-negative OPSCC disease-specific survival (DSS) and overall survival (OS). (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction.

alwin shared this article with you from Inoreader Accuracy and precision of the CTA perforator localization technique for virtual surgical planning of composite osteocutaneous fibular free flaps in head and neck reconstruction. Via Journal of Oral and Maxillofacial Surgery Virtual surgical planning (VSP), computer aided design/computer aided modeling (CAD/CAM), and three-dimensional (3D) printing technology have been shown to improve surgical accuracy and efficiency in head and neck reconstruction. However, persisting criticism of the technology is that it does not adequately address the soft-tissue related aspects of the reconstructive surgery. Prior publication on the computed tomographic angiography (CTA) perforator localization technique has demonstrated how soft tissue planning can be incorporated directly into existing VSP workflows. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Incisional Biopsies Reliable to Select Definitive Treatment in Patients with Ameloblastoma of the Jaws? A 15-year Interdisciplinary Retrospective Study

alwin shared this article with you from Inoreader Are Incisional Biopsies Reliable to Select Definitive Treatment in Patients with Ameloblastoma of the Jaws? A 15-year Interdisciplinary Retrospective Study Via Journal of Oral and Maxillofacial Surgery Ameloblastomas are tumors of odontogenic epithelium that, although benign, can have a locally aggressive course causing significant morbidity. WHO classifies ameloblastomas as 1 of 3 variants: solid/multicystic, unicystic, and peripheral. Resection, the standard treatment, is deemed curative, but can be debilitating to the patient. Unicystic subtype is considered less aggressive and could be treated with enucleation and curettage. The mercurial presentation of ameloblastomas makes the chosen treatment modality essential in decreasing the recurrence rates and associated morbidity. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is Bone Grafting during Implant Placement a Protective Factor against the Development of Peri-implantitis? A Retrospective Cohort Analysis

alwin shared this article with you from Inoreader Is Bone Grafting during Implant Placement a Protective Factor against the Development of Peri-implantitis? A Retrospective Cohort Analysis Via Journal of Oral and Maxillofacial Surgery This study aims to identify if the use of bone grafting at time of implant placement is a protective factor against the development of peri-implantitis. A retrospective cohort study was conducted at the Philadelphia Veterans Affairs Medical Center from 2006 to 2013. Physician encounter notes within three months of implant placement were used to gather data about patients ' health status. Operative report notes were used to assess the use of bone grafting at time of implant placement. Implant status was assessed using dental encounter notes and radiographs from follow-up appointments at one, three, five and 10 years. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.